2019
DOI: 10.1182/blood-2019-128403
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Deep Profiling of Genetic Aberrations and Clonal Evolution in Follicular Lymphoma

Abstract: Introduction: Follicular lymphoma (FL) is an indolent malignancy, characterized by multiple relapses during the disease course. Annually around 2-3% of patients experience transformation to aggressive disease (tFL), most commonly to diffuse large B-cell lymphoma (DLBCL). Both transformation and progression of disease within 2 years (POD24) are associated with poor prognosis, yet the molecular events underlying these processes are not well understood. The existence of common progenitor cells (CPC… Show more

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