Deep venous thrombosis associated with acute hematogenous osteomyelitis in children

Bouchoucha, Sami; Benghachame, F.; Trifa, Mehdi; Saied, W.; Douira, W.; Nessib, Mohamed Nabil; Ghachem, Maher Ben

doi:10.1016/j.otsr.2010.05.006

Cited by 48 publications

(40 citation statements)

References 15 publications

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“…Other studies have also reported a significantly higher complication rates particularly DVT and pulmonary complications in patients with MRSA osteoerticular infections. 7,8,13,14 Early diagnosis and aggressive antibiotic and surgical treatment can prevent mortality and morbidity associated …”

Section: Discussionmentioning

confidence: 99%

“…1,7 Studies have also shown that musculoskeletal infections by MRSA have a higher incidence of deep vein thrombosis (DVT) and septic pulmonary emboli. 8,9 To mitigate morbidity and mortality due to MRSA, it is imperative to establish the diagnosis by high index of clinical suspicion along with imaging and growing the infecting organism in culture, which promotes the prompt institution of appropriate antibiotic therapy early in the course of the disease. However, numerous studies have quoted a culture negativity rate ranging from 30 to 50 percent.…”

Section: E3mentioning

confidence: 99%

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Clinical and haematological predictors of acute hematogenous Methicillin Resistant Staphylococcus aureus (MRSA) osteomyelitis & septic arthritis

Agrawal

Sharma

Dhiman

et al. 2015

Journal of Orthopaedics

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Results: Of 81 patients enrolled in the study, 61 were culture positive (22% MRSA). Statistically significant difference was found only in CRP (P < 0.001). ROC curve analysis shows that CRP levels of >13.9 mg/L, MRSA bone and joint infection could be predicted with 92.9% sensitivity and 79.1% specificity (AUC ¼ 89.1). Conclusion:Estimation of serum CRP levels at the time of presentation can aid in distinguishing MRSA osteomyelitis from non MRSA one.

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Section: Discussionmentioning

confidence: 99%

Section: E3mentioning

confidence: 99%

Clinical and haematological predictors of acute hematogenous Methicillin Resistant Staphylococcus aureus (MRSA) osteomyelitis & septic arthritis

Agrawal

Sharma

Dhiman

et al. 2015

Journal of Orthopaedics

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“…With the emergence of CA-MRSA, deep venous thrombosis (DVT) adjacent to the site of OM has been described by several groups (506)(507)(508)(509)(510). DVT with acute OM has been associated with MRSA (506, 508), PVL-positive strains of S. aureus (510), and USA300 in particular (507).…”

Section: Osteoarticular Infections In Childrenmentioning

confidence: 99%

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

et al. 2015

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SUMMARY Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.

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“…Annual incidence is 0.06-0.07/10,000 compared to 2-7/10,000 in adults (Lachambre et al, 2005). The incidence in association with acute osteomyelitis, however, is increasing and is present in around 9% of paediatric cases with osteomyelitis (Bouchoucha et al, 2010). Such patients with DVT (Figure 4) are more likely to be infected with MRSA.…”

Section: Venous Thromboembolismmentioning

confidence: 99%

“…Surgery is likewise more likely to be required for abscess drainage in these patients (Hollmig et al, 2007, Bouchoucha et al, 2010). …”

Section: Venous Thromboembolismmentioning

confidence: 99%

Panton-Valentine leukocidin osteomyelitis in children: a growing threat

et al. 2015

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Deep venous thrombosis associated with acute hematogenous osteomyelitis in children

Abstract: Level III.

Cited by 48 publications

References 15 publications

Clinical and haematological predictors of acute hematogenous Methicillin Resistant Staphylococcus aureus (MRSA) osteomyelitis & septic arthritis

Clinical and haematological predictors of acute hematogenous Methicillin Resistant Staphylococcus aureus (MRSA) osteomyelitis & septic arthritis

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

Panton-Valentine leukocidin osteomyelitis in children: a growing threat

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