DEFB1 rs11362 Polymorphism and Risk of Chronic Periodontitis: A Meta-Analysis of Unadjusted and Adjusted Data

Abstract

Objective: Chronic periodontitis (CP) is a growing problem that affects the worldwide population, having significant impacts on people's daily lives and economic development. Genetics is an important component in the determination of individual susceptibility to periodontal diseases. Numerous studies have been performed to investigate the association between beta defensin 1 (DEFB1) rs11362 polymorphism and risk of CP, but the results are still inconclusive. Therefore, we conducted this meta-analysis to ascertain whether this variation in DEFB1 is associated with CP susceptibility.Methods: The relevant studies were searched in PubMed and Chinese National Knowledge Infrastructure (CNKI) databases up to January 9, 2018. Two independent authors selected citations and extracted the data from eligible studies. Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were used to assess the strength of the association.Results: Seven case-control studies were included in this meta-analysis. Based on unadjusted data, there was no obvious association between DEFB1 rs11362 polymorphism and CP risk in all genetic models (A vs. G: OR = 0.86, 95%CI = 0.61–1.20; AA vs. GG: OR = 0.83, 95% CI = 00.50–1.39; AG vs. GG: OR = 1.01, 95%CI = 0.73–1.39; AG+AA vs. GG: OR = 0.91, 95% CI = 00.74–1.11; and AA vs. AG+GG: OR = 0.83, 95% CI = 00.57–1.21); the results of adjusted data also showed no significant relationship. Subgroup analyses based on ethnicity, participants' smoking status, HWE in controls and severity of CP all revealed similar results to that of the overall analysis. Sensitivity analysis indicated the results were robust and no evidence of publication bias was found.Conclusions: Our meta-analysis suggests that DEFB1 rs11362 polymorphism may not have an important effect on the risk of CP. Further large-scale and well-designed studies are necessary to validate our conclusion in the future.

Gingival recession and attachment loss: Cross-sectional and retrospective data of 10 years

“…The analysis of the results was performed with repeated measurements by the Friedman test. 1,3,13,22 All the groups showed improvements in all the clinical parameters after six months. Inter-group comparisons of GI, CAL, and PPD parameters did not reveal any statistically significant differences.…”

“…The majority of the study population were diagnosed with periodontitis with a higher proportion in the highest risk category according to PIRI scores. 1,4,13,15,17 Conclusions Gingival recession and attachment loss showed declining values when we compared cross-sectional and retrograde data on these concepts collected in patients included in this study. Patients' sensitivity increases to the consequences of the existing periodontium in the oral cavity, which passes into active and invasive stages but does not fully heal.…”

“…Cross-sectional studies performed on a large number of subjects require conscious human resources for the application of specific periodontal diagnostic tools. 1,4,13,14…”

Beta‐defensin 1 gene polymorphisms in the pathologies of the oral cavity—Data from meta‐analysis: Association only with rs1047031 not with rs1800972, rs1799946, and rs11362

“…However, the latter authors identified DEFB1 ‐G1654A polymorphism as a potential genetic susceptibility factor for periodontitis. No associations were detected also by Shao et al, who analyzed just the role of rs11362 in the development of chronic periodontitis 25 …”

Association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis: A meta-analysis

“…With the development of genetic engineering technology and continuous research on human gene polymorphism, it is gradually recognized that gene polymorphism may be a material basis for the individual difference of periodontal diseases. Gene-related studies have confirmed that chronic periodontitis and aggressive periodontitis may be two different diseases [12], and interleukin (IL) gene polymorphisms possibly play a pivotal role in the occurrence and progression of chronic periodontitis [13][14][15]. The genes in IL-1 family have allele polymorphisms which may be related to the susceptibility of chronic periodontitis, in which single nucleotide polymorphism (SNP) -889C/T (rs1800587) in IL-1A gene is researched extensively [16][17][18][19].…”