Defeat undefeatable: Ionic liquids as novel antimicrobial agents

Michalski, Jakub; Odrzygóźdź, Cezary; Mester, Patrick; Narożna, Dorota; Cłapa, Tomasz

doi:10.1016/j.molliq.2022.120782

Cited by 14 publications

(20 citation statements)

References 193 publications

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“…The same was observed by Cłapa et al (2021) during the investigation of four P. aeruginosa strains, including three clinical isolates [ 5 ]. Moreover, the obtained results are in line with the trend described in numerous studies, indicating that the increased length of alkyl substituents and the number of long alkyl groups is one of the strongest determinants of ionic liquids toxicity against bacteria [ 6 , 15 , 51 , 52 , 53 ].…”

Section: Discussionsupporting

confidence: 89%

“…In this study, we could show that ILs with a [Dec 2 Mor] + cation are more toxic to P. aeruginosa strains than ILs with a [DecEtMor] + cation and that all morpholinium-based HILs were decreasing the virulence of the investigated strains. We could recently also show that ILs are influencing at the molecular levels of different and pathogenic isolates of P. aeruginosa , which cause problems not only with microorganisms (free-living bacterial cells and also with biofilms), but mostly with human beings [ 6 ]. It is known that at the current moment, the chemical structures can be synthesize in an amount abound 10 18 so the new applications of the ILs still cannot be known [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…The set of Gram-positive and Gram-negative bacteria ( Listeria monocytogenes , Salmonella enterica , Escherichia coli , Lactococcus lactis and Pseudomonas syringae ) provides a broad spectrum of different bacterial orders and is anticipated to reveal species-specific differences [ 8 , 9 , 10 , 11 ]. In the case of the bactericidal activity of ILs, different mode-of-action was previously described, such as generating reactive oxygen species, influencing membrane permeability, activating the SOS system that is responsible for protecting living organisms, or inhibiting enzyme activity, each of which can determine the general applicability of ILs as antimicrobials [ 6 , 9 , 12 , 13 , 14 , 15 ]. As in our previous study, only strains of the Gram-negative P. aeruginosa were tested, it is crucial to confirm the activity against other species, including also Gram-positive bacteria.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Michalski

Sommer

Rossmanith

et al. 2023

IJMS

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Witnessed by the ongoing spread of antimicrobial resistant bacteria as well as the recent global pandemic of the SARS-CoV-2 virus, the development of new disinfection strategies is of great importance, and novel substance classes as effective antimicrobials and virucides are urgently needed. Ionic liquids (ILs), low-melting salts, have been already recognized as efficient antimicrobial agents with prospects for antiviral potential. In this study, we examined the antiviral activity of 12 morpholinium based herbicidal ionic liquids with a tripartite test system, including enzyme inhibition tests, virucidal activity determination against five model viruses and activity against five bacterial species. The antimicrobial and enzymatic tests confirmed that the inhibiting activity of ILs corresponds with the number of long alkyl side chains and that [Dec2Mor]+ based ILs are promising candidates as novel antimicrobials. The virucidal tests showed that ILs antiviral activity depends on the type and structure of the virus, revealing enveloped Phi6 phage as highly susceptible to the ILs action, while the non-enveloped phages PRD1 and MS2 proved completely resistant to ionic liquids. Furthermore, a comparison of results obtained for P100 and P001 phages demonstrated for the first time that the susceptibility of viruses to ionic liquids can be dependent on differences in the phage tail structure.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Michalski

Sommer

Rossmanith

et al. 2023

IJMS

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“…The other researcher applied a series of 1-alkylquinolinium bromide against clinically relevant microbes such as C. albicans . They reported that tested ILs had broad-spectrum antimicrobial activity against fungi and Gram-positive bacteria ( 39 ). In this presentation, we evaluated the antifungal activity of all eight novel ILs similar to the previous study ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of new methionine-based ionic liquid on the CDR1 and CDR2 gene expression on sensitive and resistant strains of Candida albicans

Eslami

Ezabadi

Bayat

et al. 2023

IJM

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Background and Objectives: Previous researchers showed the antimicrobial ability of ionic liquids (ILs) on different infec- tive agents. ILs can dissolve organic components, especially DNA molecules. Among synthesized eight binary ILs mixtures, we have chosen ([Met-HCl] [PyS]) IL for determining the antifungal ability of IL against Candida albicans cells. Materials and Methods: Well diffusion assay, chrome agar and Germ tube tests were used to detect the Candida samples. PCR, real-time-PCR, and flow cytometry tests were performed to determine the IL's rate of toxic ability. Results: Well diffusion assay revealed the diameters of the growth inhibition zones were the largest in IL with methionine and Proline amino acids. Minimum inhibitory concentration (MIC) and the Minimum fungicidal concentration (MFC) tests showed that they inhibited the growth of the C. albicans at a range from 250 µg/ml for sensitivity and 400 µg/ml for resis- tance, MIC average of all samples were 341.62 ± 4.153 µg/ml. IL reduced the expression of CDR1 and CDR2 the genes encoded by the major protein of ABC system transporter by 2.1 (P= 0.009) and 1.2 fold (P= 0.693), revealed by PCR and real time-PCR. In the flow cytometry test, there were increasing dead cells after treating with the ([Met-HCl] [PyS]) even in the most resistant strain. Conclusion: The novel IL was effective against the most clinical and standard C. albicans.

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“…14 ILs have also shown antimicrobial potential, wherein the toxicity of ILs is inversely associated with the length of the alkyl chain present in their structure. 15 ILs are made up of large combinations of anions and cations or both, and such fine-tuning with respect to the selection of different anions and cations can be performed on the basis of the type of reaction or the compound intended to be synthesized. Thus, they are also referred to as ‘designer solvents’.…”

Section: Introductionmentioning

confidence: 99%

The Synthesis of Nitrogen- and Oxygen-Containing Heterocyclic Scaffolds Assisted by Ionic Liquids: A 2022 Literature Survey

Dhameliya,

Raghani,

Desai

et al. 2023

Synlett

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Heterocycles have gained recognition as vital components in approved drugs, drawing substantial attention from the scientific community. Ionic liquids (ILs) have been utilized for their transformative role in heterocycle synthesis, showcasing distinctive properties that are pivotal in diverse chemical transformations, while also acting as effective catalysts and offering safer alternatives to volatile organic solvents. This review delves into the synthesis of nitrogen- and oxygen-containing heterocyclic structures, employing various ILs such as ammonium, cholinium, DABCO-based, DBU-based, guanidinium, imidazolium, phosphonium, pyridinium, and miscellaneous. They have proven indispensable in facilitating reactions like Fischer-indole synthesis, Biginelli, Knoevenagel condensations and many more. Notably, the recyclability of ILs serves as a valuable asset, aiding in the completion of intricate synthetic pathways, multicomponent reactions, and one-pot syntheses, ultimately enhancing yields. This review seeks to guide researchers in selecting suitable ILs for specific chemical reactions, enabling the synthesis of aza- and/ or oxa-heterocycles described in 2022. This advancement holds promising prospects for drug development and other applications within the domain of heterocyclic chemistry.

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Defeat undefeatable: Ionic liquids as novel antimicrobial agents

Cited by 14 publications

References 193 publications

Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Effect of new methionine-based ionic liquid on the CDR1 and CDR2 gene expression on sensitive and resistant strains of Candida albicans

The Synthesis of Nitrogen- and Oxygen-Containing Heterocyclic Scaffolds Assisted by Ionic Liquids: A 2022 Literature Survey

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