Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet

Kadowaki, Tomoko; Kido, Mizuho A.; Hatakeyama, Jun; Okamoto, Kuniaki; Tsukuba, Takayuki; Yamamoto, Kazuo

doi:10.1016/j.bbrc.2014.02.089

Cited by 13 publications

(7 citation statements)

References 21 publications

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“…Ctse is an intracellular aspartic proteinase highly expressed in immune-related cells such as macrophages. Its main role is in macrophage infiltration, adipogenesis, and hepatic steatosis [54]. Orm2 is expressed in hepatocytes and adipocytes and secreted into plasma under metabolic and inflammatory stress as an acute phase reactant immunomodulator protein [55].…”

Section: Discussionmentioning

confidence: 99%

Chardonnay Grape Seed Flour Ameliorates Hepatic Steatosis and Insulin Resistance via Altered Hepatic Gene Expression for Oxidative Stress, Inflammation, and Lipid and Ceramide Synthesis in Diet-Induced Obese Mice

Seo

Bartley²,

Tam³

et al. 2016

PLoS ONE

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To identify differentially expressed hepatic genes contributing to the improvement of high-fat (HF) diet-induced hepatic steatosis and insulin resistance following supplementation of partially defatted flavonoid-rich Chardonnay grape seed flour (ChrSd), diet-induced obese (DIO) mice were fed HF diets containing either ChrSd or microcrystalline cellulose (MCC, control) for 5 weeks. The 2-h insulin area under the curve was significantly lowered by ChrSd, indicating that ChrSd improved insulin sensitivity. ChrSd intake also significantly reduced body weight gain, liver and adipose tissue weight, hepatic lipid content, and plasma low-density lipoprotein (LDL)-cholesterol, despite a significant increase in food intake. Exon microarray analysis of hepatic gene expression revealed down-regulation of genes related to triglyceride and ceramide synthesis, immune response, oxidative stress, and inflammation and upregulation of genes related to fatty acid oxidation, cholesterol, and bile acid synthesis. In conclusion, the effects of ChrSd supplementation in a HF diet on weight gain, insulin resistance, and progression of hepatic steatosis in DIO mice were associated with modulation of hepatic genes related to oxidative stress, inflammation, ceramide synthesis, and lipid and cholesterol metabolism.

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Section: Discussionmentioning

confidence: 99%

Chardonnay Grape Seed Flour Ameliorates Hepatic Steatosis and Insulin Resistance via Altered Hepatic Gene Expression for Oxidative Stress, Inflammation, and Lipid and Ceramide Synthesis in Diet-Induced Obese Mice

Seo

Bartley²,

Tam³

et al. 2016

PLoS ONE

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“…Cfhr1 is upregulated in the mouse retina in response to a different high fat diet (Z heng et al 2015). Ctse deficient mice fed a high fat diet showed hypercholesterolemia, reduced body weight gain and impaired fat development compared to controls mice (K adowaki et al 2014). F13b is part of the coagulation cascade and has not been previously associated with cholesterol metabolism.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Sex and Diet on Physiology and Liver Gene Expression in Diversity Outbred Mice

Gatti

Šimeček

Somes

et al. 2017

Preprint

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Inter-individual variation in metabolic health and adiposity is driven by many factors. Diet composition and genetic background and the interactions between these two factors affect adiposity and related traits such as circulating cholesterol levels. In this study, we fed 850 Diversity Outbred mice, half females and half males, with either a standard chow diet or a high fat, high sucrose diet beginning at weaning and aged them to 26 weeks. We measured clinical chemistry and body composition at early and late time points during the study, and liver transcription at euthanasia. Males weighed more than females and mice on a high fat diet generally weighed more than those on chow. Many traits showed sex- or diet-specific changes as well as more complex sex by diet interactions. We mapped both the physiological and molecular traits and found that the genetic architecture of the physiological traits is complex, with many single locus associations potentially being driven by more than one polymorphism. For liver transcription, we find that local polymorphisms affect constitutive and sex-specific transcription, but that the response to diet is not affected by local polymorphisms. We identified two loci for circulating cholesterol levels. We performed mediation analysis by mapping the physiological traits, given liver transcript abundance and propose several genes that may be modifiers of the physiological traits. By including both physiological and molecular traits in our analyses, we have created deeper phenotypic profiles to identify additional significant contributors to complex metabolic outcomes such as polygenic obesity. We make the phenotype, liver transcript and genotype data publicly available as a resource for the research community.

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“…Adipose tissue and liver are the most important organs which control lipid metabolism in our body and impaired adipogenesis have been linked to liver lipogenesis in some studies [9][10][11][12][13]. Diraison et al [9] found increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in obese patients.…”

Section: Discussionmentioning

confidence: 97%

“…ACCEPTED MANUSCRIPT 11 as, hepatic lipid deposition, diabetes and cardiovascular disease [11][12][13]. A large number of studies have confirmed that chronic inflammation is closely related to both adipogenesis and hepatic lipogenesis [14][15][16].…”

Section: Accepted Manuscriptmentioning

confidence: 93%

Impaired adipogenesis in adipose tissue associated with hepatic lipid deposition induced by chronic inflammation in mice with chew diet

et al. 2015

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Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet

Cited by 13 publications

References 21 publications

Chardonnay Grape Seed Flour Ameliorates Hepatic Steatosis and Insulin Resistance via Altered Hepatic Gene Expression for Oxidative Stress, Inflammation, and Lipid and Ceramide Synthesis in Diet-Induced Obese Mice

Chardonnay Grape Seed Flour Ameliorates Hepatic Steatosis and Insulin Resistance via Altered Hepatic Gene Expression for Oxidative Stress, Inflammation, and Lipid and Ceramide Synthesis in Diet-Induced Obese Mice

The Effects of Sex and Diet on Physiology and Liver Gene Expression in Diversity Outbred Mice

Impaired adipogenesis in adipose tissue associated with hepatic lipid deposition induced by chronic inflammation in mice with chew diet

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