Defective barrier function in melasma skin

Lee, D.J.; Lee, J.; Ha, Jaehyun; Park, K.-C.; Ortonne, Jean‐Paul; Kang, Hee Young

doi:10.1111/j.1468-3083.2011.04337.x

Cited by 56 publications

(58 citation statements)

References 22 publications

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“…Melanin index, erythema index, and SC hydration were significantly higher in melasma skin in that study, which was similar to the findings of our study. TEWL was also higher in that report, but it didn't reach significance level [7].…”

Section: Discussionmentioning

confidence: 89%

“…Dark skin has more cell layers in stratum corneum, greater electrical resistance, better intercellular cohesion, faster recovery after barrier damage and more TEWL in stripped skin [7]. A more resistant barrier is also displayed in dark skin [12].…”

Section: Discussionmentioning

confidence: 97%

“…On the other hand, chronic UV radiation (which is the main pathogenic factor in melisma) causes downregulation of lipid metabolism-related genes so less synthesis of epidermal free fatty acids (FFA) and triglycerides occurs in melisma [7]. Also downregulation of several lipid metabolism-associated genes such as peroxisome proliferator-activated receptor alpha (PPARA) leads to barrier damage in melisma [7].…”

Section: Discussionmentioning

confidence: 99%

“…A previous study compared the biophysical characteristics of melasma with normal adjacent skin in Asian patients and showed melanin index, erythema index, and SC hydration were significantly higher in melasma skin [7].…”

Section: Introductionmentioning

confidence: 99%

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Biophysical Characteristics of Melasma Skin Comparing with the Perilesional Normal Skin and its Relation to the Melasma Subtype

Rahrovan¹,

Hasanzadeh²,

Khodakarim³

et al. 2015

Pigmentary Disorders

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show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biophysical Characteristics of Melasma Skin Comparing with the Perilesional Normal Skin and its Relation to the Melasma Subtype

Rahrovan¹,

Hasanzadeh²,

Khodakarim³

et al. 2015

Pigmentary Disorders

View full text Add to dashboard Cite

show abstract

“…Topical tretinoin used as a monotherapy leads to a clinical improvement of melasma over a period of at least 24 weeks 101,102 , possibly by encouraging clearance via the lymphatics 103 . In their studies on melasma Lee et al 104 did not find any difference between transepidermal water loss of lesional skin and normal skin, but did find that the skin of melasma is more hydrated and recovers from tape stripping more slowly. The role of keratinocyte in the pathophysiology of melasma has also been attributed to the activation of inducible nitric oxide synthase within keratinocytes and activation of the AKT/NFRB pathway 105 .…”

Section: Melasma: a Model Of Incontinencementioning

confidence: 99%

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Arianayagam

Ryan

2016

Current Science

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Biomedicine has not provided a complete explanation with fully effective therapies for disorders of pigmentation. Biomedicine emphasizes the role of melanocyte for protection from UV rays and as a determinant of skin colour. These important properties acquired a genetic basis much later than other functions, many relating to cell contact as in the keratinocyte -melanocyte unit, or as with the synapses of the neurological system. There are other roles, biochemical and mechanical, of melanocyte. Management that is inclusive of a maximally holistic approach justifies the use of diverse herbals, yoga and concern for cultural awareness provided by integrated medicine. Vitiligo provides a model which demonstrates that Ayurveda has a richer view of its presentations, possibly a stronger line on its pathogenesis, and a huge range of herbals, many now backed by studies from ethnobotanical laboratories, awaiting research into the many possible mechanisms by which they may act in the wide and complex field of melanocyte biochemistry.

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Will Repeated Low‐Energy 1064‐nm Q‐Switched Nd:YAG Laser Treatment Sessions Affect Facial Skin Sensitivity? Results of a 12‐Month, Prospective, Randomized Split‐Face Study

et al. 2021

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Background and Objective To compare changes in skin sensitivity before and after treatment with a 1064‐nm Q‐switched Nd:YAG laser in healthy individuals, and to provide a reference for clinicians to use this laser reasonably. Study Design/Materials and Methods Nineteen healthy female volunteers underwent 10 random unilateral 1064‐nm Q‐switched Nd:YAG laser treatments. The skin transepidermal water loss rate (TEWL), skin glossiness, epidermal and dermal thickness and density, current perception threshold (CPT) value, facial blood perfusion were determined before and after treatment at different time points. Moreover, the changes in skin barrier function, blood vessels, and sensory nerve reaction in the treated and untreated sides of the face were recorded before and after treatment. Results Seventeen volunteers completed the 12‐month follow‐up study after 1064‐nm Q‐switched Nd:YAG laser treatment. At D3, M3, and M6, skin TEWL was decreased on the treated side of the face. Skin glossiness was significantly improved in the early post‐treatment period (D1–D7) and M3, M6, and M12 compared with the untreated side of the face. There was no significant change in dermal and epidermal thickness or density at all time points before and after treatment. There were no significant differences in sensory nerve CPT values and local blood flow volume or velocity between the treated side of the face and the untreated side before and after treatment. Conclusion Multiple low‐energy 1064‐nm Q‐switched Nd:YAG laser treatments will not affect the barrier function of facial skin, skin nerve sensitivity, or local microcirculation of healthy skin over the long term. Therefore, 1064‐nm Q‐switched Nd:YAG laser treatment is safe, and does not alter skin sensitivity. Lasers Surg. Med. © 2021 Wiley Periodicals LLC

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Defective barrier function in melasma skin

Abstract: Melasma skin is characterized by impaired stratum corneum integrity and a delayed barrier recovery rate.

Cited by 56 publications

References 22 publications

Biophysical Characteristics of Melasma Skin Comparing with the Perilesional Normal Skin and its Relation to the Melasma Subtype

Biophysical Characteristics of Melasma Skin Comparing with the Perilesional Normal Skin and its Relation to the Melasma Subtype

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Will Repeated Low‐Energy 1064‐nm Q‐Switched Nd:YAG Laser Treatment Sessions Affect Facial Skin Sensitivity? Results of a 12‐Month, Prospective, Randomized Split‐Face Study

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