Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1

Yang, Yuanxin; Zhang, Jian; lv, Mingming; Cui, Na; Shan, Bing; Sun, Qi; Yan, Lingjie; Zhang, Mengmeng; Zou, Chengyu; Yuan, Junying; Xu, Daichao

doi:10.1038/s41556-024-01374-2

Cited by 4 publications

(2 citation statements)

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“…There is also necroptosis, a programmed form of necrosis or inflammatory cell death. Inhibition of necroptosis and, in particular, Receptor-interacting serine/threonine-protein kinase 1 (RIPK1 kinase) activity reduces inflammation and leads to a significant increase in lifespan [49,50]. The IC CHAOS dissonance accompanied by AVDS, MMDS aggravates Electro-Ion Membrane Distress Syndrome, accompanied by Abnormal/extreme myelopoiesis and generates MODS, creating extreme genomic, transcriptomic, proteomic, metabolic, and phenomenal functional-structural disorders myelopoiesis, are reduced, incl.…”

Section: Lysosomal Mitochondrial Clearance Of Autophagy Mitophagy Mit...mentioning

confidence: 99%

“…Comprehensive life support and treatment capable of preventing organ transplantation and especially lung transplantation in advanced forms of SARS-Cov2 [102]. Respiratory cardiac using markers, including galectin-3 in heart disease [50] and cerebral support [103][104][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121], has justified itself not only in critical-terminal obstetrics bleeding [122] but also with massive injuries and in oncological MODS and even with coronavirus infection SARS-Cov2 / COVID19, where Acute Vascular Distress Syndrome is significant for the development of MIS. In the prevention of the SARS-Cov2 / COVID-19 pandemic, vaccination plays a special role [123] based on quality management [124,125].…”

Section: Multi-organ Supportive Therapy (Most) Extracorporeal Life Su...mentioning

confidence: 99%

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Role Of Acute Vascular Distress Syndrome In The Development Of Multisystem Inflammatory Syndrome In Sars-Cov-2 And Modern Views On The Research And Treatment Of Critical Coronavirus

Vasilieva,

Vasiliev

2024

SJMAS

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Background: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the complex pathology of the virus, which extends beyond respiratory symptoms to include multisystem inflammatory syndrome (MIS). This review explores the role of Acute Vascular Distress Syndrome (AVDS) in the development of MIS in both adults (MIS-A) and children (MIS-C), providing a comprehensive overview of modern research and treatment approaches for severe coronavirus infections. Methods and Materials: This review synthesizes findings from multiple studies and clinical reports to analyze the mechanisms by which SARS-CoV-2 induces AVDS and subsequently MIS. Key materials include molecular and cellular research data, clinical case studies, and treatment protocols. Diagnostic tools such as PCR and serological testing, as well as various biomarkers like neurofilament light chain and galectin-3, are discussed to elucidate their roles in identifying and managing severe COVID-19 cases. Results: The interaction between SARS-CoV-2 and host endothelial cells, mediated by ACE2 receptors, triggers a cascade of inflammatory responses leading to AVDS. This syndrome is characterized by severe endothelial dysfunction, cytokine storms, and mitochondrial distress, which collectively contribute to the pathogenesis of MIS. Clinical evidence indicates that AVDS is a critical factor in the severity of COVID-19, with widespread implications for multiple organ systems, including the central and peripheral nervous systems. Conclusion: Understanding the role of AVDS in MIS development offers valuable insights into the pathophysiology of severe COVID-19. Effective management requires a multifaceted approach, combining antiviral therapies, immunomodulators, and supportive treatments like extracorporeal membrane oxygenation (ECMO). Future research should focus on targeted therapies to mitigate endothelial damage and improve patient outcomes in critical COVID-19 cases.

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Section: Lysosomal Mitochondrial Clearance Of Autophagy Mitophagy Mit...mentioning

confidence: 99%