Defense Responses of the Marine-Derived Fungus Аspergillus tubingensis to Alkylphenols Stress

Кузикова, И. Л.; Рыбальченко, Оксана Владимировна; Курашов, Е. А.; Krylova, Yulya; Safronova, Vera I.; Медведева, Н. Г.

doi:10.1007/s11270-020-04639-2

Cited by 10 publications

(5 citation statements)

References 124 publications

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“…This strain was able to degrade 91 and 96% of 4-tertoctylphenol (297) and nonylphenol, respectively, after 120 h. According to GC-MS analysis, the main intermediate product in the biodegradation of 4-tert-octylphenol (297) was p-tertoctylresorcinol (298; Figure 14C). The filtrates of the fungal cultures after biodegradation of both alkylphenols by A. tubingensis F6 did not show toxicity in the assay with Paramecium caudatum Ehrenberg as a bioindicator, confirming the potential biotechnological application of this fungus in wastewater bioremediation (Kuzikova et al, 2020).…”

Section: Other Persistent Organic Pollutantsmentioning

confidence: 67%

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Marine-derived fungi as biocatalysts

Virués-Segovia

Muñoz-Mira²,

Durán-Patrón³

et al. 2023

Front. Microbiol.

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Marine microorganisms account for over 90% of ocean biomass and their diversity is believed to be the result of their ability to adapt to extreme conditions of the marine environment. Biotransformations are used to produce a wide range of high-added value materials, and marine-derived fungi have proven to be a source of new enzymes, even for activities not previously discovered. This review focuses on biotransformations by fungi from marine environments, including bioremediation, from the standpoint of the chemical structure of the substrate, and covers up to September 2022.

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Section: Other Persistent Organic Pollutantsmentioning

confidence: 67%

“…(B) Biodegradation of the explosive TNT (293) by Yarrowia lipolytica NCIM 3589 (Jain et al, 2004). (C) Biodegradation of the chemical 4-tert-octylphenol (297) by Aspergillus tubingensis F6 (Kuzikova et al, 2020(Kuzikova et al, ). 10.3389/fmicb.2023 in Microbiology 26 frontiersin.org…”

Section: Discussionmentioning

confidence: 99%

Marine-derived fungi as biocatalysts

Virués-Segovia

Muñoz-Mira²,

Durán-Patrón³

et al. 2023

Front. Microbiol.

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“…The results were expressed in µmol/g dw. Detailed descriptions of the procedures for determining SOD, CAT, GLU, and MDA were presented earlier [50,61].…”

Section: Assay Of Antioxidants and Lipid Peroxidationmentioning

confidence: 99%

Algicidal Activity and Microcystin-LR Destruction by a Novel Strain Penicillium sp. GF3 Isolated from the Gulf of Finland (Baltic Sea)

Kuzikova,

Zaytseva,

Chernova

et al. 2023

Toxins

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The present article focuses on a strain of ascomycete GF3 isolated from a water sample taken in the Gulf of Finland. Based on phylogenetic analysis data, the isolate was identified as Penicillium sp. GF3. The fungus GF3 demonstrates algicidal activity towards cyanobacteria (98–100%). The algicidal effect on green algae did not exceed 50%. The isolate GF3 exhibits an indirect attack mode by releasing metabolites with algicidal and/or lytic activity into the environment. Moreover, the strain Penicillium sp. GF3 is able to degrade MC-LR. After 72 h of GF3 cultivation, the MC-LR content was reduced by 34.1% and 26.7% at initial 0.1 μg/mL and 0.45 μg/mL concentrations, respectively. The high stress resistance of the GF3 to toxic MC-LR is provided by a 1.5-fold activation of catalase activity and a change in the reduced glutathione content. Additionally, during the MC-LR biotransformation, a MC-LR-GSH conjugate and linearized MC-LR were identified. The linearized MC-LR in the presence of fungi capable of degrading MCs was revealed for the first time. Using Daphnia magna as a bioindicator, it was shown that the MC-LR biotransformation led to the formation of less toxic intermediates. The toxicity of the fungal filtrate is reduced by five times compared to the abiotic control. Our findings enhance the understanding of the role that ascomycete fungi have as potential bioagents for cyanoHABs to control and detoxify water bodies.

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“…Enhancement of metabolites yield can be achieved applying stressing conditions during fungal development, aiming at activating unconventional metabolic routes related to the production of substances linked to defense (biotic stress) or adaptation (abiotic stress). This technique is particularly interesting for the production of fungal pigments, since these metabolites are associated with defense against various types of abiotic stress [ 96 ]. Abiotic stress is usually caused by altering nutrients (carbon, nitrogen, minerals) and conditions (temperature, length, oxygen supply) in the culture medium, improving pigments production, although independently of directing to a single pigment color.…”

Section: Processing and Innovations In Azaphilones Productionmentioning

confidence: 99%

“… Halogenated azaphilones produced by marine and terrestrial fungi. 113–114 : penicilazaphilones D and E; 115 : sclerotiorin; 116 : N-ethylbenzene-sclerotioramine [ 95 , 96 ]. …”

Section: Figurementioning

confidence: 99%

Recent Findings in Azaphilone Pigments

Pimenta

Gomes

Cardoso

et al. 2021

JoF

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Filamentous fungi are known to biosynthesize an extraordinary range of azaphilones pigments with structural diversity and advantages over vegetal-derived colored natural products such agile and simple cultivation in the lab, acceptance of low-cost substrates, speed yield improvement, and ease of downstream processing. Modern genetic engineering allows industrial production, providing pigments with higher thermostability, water-solubility, and promising bioactivities combined with ecological functions. This review, covering the literature from 2020 onwards, focuses on the state-of-the-art of azaphilone dyes, the global market scenario, new compounds isolated in the period with respective biological activities, and biosynthetic pathways. Furthermore, we discussed the innovations of azaphilone cultivation and extraction techniques, as well as in yield improvement and scale-up. Potential applications in the food, cosmetic, pharmaceutical, and textile industries were also explored.

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Defense Responses of the Marine-Derived Fungus Аspergillus tubingensis to Alkylphenols Stress

Cited by 10 publications

References 124 publications

Marine-derived fungi as biocatalysts

Marine-derived fungi as biocatalysts

Algicidal Activity and Microcystin-LR Destruction by a Novel Strain Penicillium sp. GF3 Isolated from the Gulf of Finland (Baltic Sea)

Recent Findings in Azaphilone Pigments

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