Defensin alpha 6 (DEFA6) is a prognostic marker in colorectal cancer

Jeong, Dongjun; Kim, Hyeongjoo; Kim, Doyeon; Ban, Seona; Oh, Seung-Hyun; Ji, Sanghee; Kang, Dong‐Hyun; Lee, Hyun-Yong; Ahn, Tae Sung; Kim, Hee Jin; Bae, Sang Byung; Lee, Moon Soo; Kim, Chang‐Jin; Kwon, Hyog Young

doi:10.3233/cbm-182221

Cited by 11 publications

(12 citation statements)

References 25 publications

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“…In addition, DEFA6 is highly expressed in CRC-derived cell lines and in colon biopsy specimens from patients with CRC. 50 Gene silencing of DEFA6 impairs proliferation, migration, and invasion of CRC cell lines, 50 indicating a pro-oncogenic role of DEFAs. Of note, we demonstrated that UC-derived colonoids exhibit less SMOX and more DEFA5 and DEFA6 transcripts compared with normal colonoids and that Spd treatment dampens DEFA5 and DEFA6 expression.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Spermidine in Colitis and Colon Carcinogenesis

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Protective Role of Spermidine in Colitis and Colon Carcinogenesis

et al. 2022

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“…A significantly increased level of HNP1-3 was also detected in cancer tissues and serum of patients with metastatic colorectal cancer [ 264 ]. Similar to HNP1-3, a high level of HD6 was detected in colon cancer tissues and colon cancer cell lines [ 265 ], supporting a potential prognostic value of HNP1-3 and HD6 in colorectal cancer. On the other hand, the anti-tumor activity of HNP1-3 has been reported in some types of tumors.…”

Section: Activity Of Ampsmentioning

confidence: 98%

Antimicrobial peptides: mechanism of action, activity and clinical potential

et al. 2021

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The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.

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“…Many related studies on DEFA6 and CRC are available. Regardless of contents in blood ( 23 ), mRNA expression ( 24 ), and protein contents ( 25 ), a number of works showed its high expression in CRC. Moreover, DEFA6 had a promoting effect on the proliferation, migration, invasion, and colony formation of CRC cell lines in vitro , and the growth rate of cancer cells was significantly decreased by shDEFA6 ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…Other studies also found significantly increased DEFA6 expression in colon adenoma and cancer ( 24 ). By inhibiting the function of DEFA6 by shRNA, DEFA6 promoted the proliferation, migration, invasion, and colony forming ability of CRC cells ( 25 ). A previous work that analyzed 352 patients with CRC reported that the high expression of DEFA6 was associated with the poor survival rate of patients and could be an independent prognostic marker of CRC ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of alfa defensin expression and prognosis in human colorectal cancer

Xi-nan

Lu²,

Liu³

et al. 2023

Front. Oncol.

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IntroductionColorectal cancer (CRC) is a serious threat to human health. Screening new biomarkers can provide basis for improving the prognosis and individualized treatment of CRC. Although some members of the defensin family were found increased in pancreatic cancer and CRC, their exact function and clinical significance remain unclear.MethodsIn this study, the expression, correlation, mutation, and functional enrichment of several defensin family members in pancreatic cancer and CRC were analyzed using tumor public databases and verified in several patients.ResultsResults showed no significant correlation between the expression levels of DEFA1-4 and CRC. The expression levels of DEFA5 and DEFA6 significantly increased in CRC tissues compared with those in normal tissues. DEFA5 may be associated with better prognosis of CRC, while DEFA6 may be associated with poor prognosis. Immunohistochemistry (IHC) experiments showed that the expression of DEFA6 was significantly higher in adenoma than in normal mucosa and slightly higher in carcinoma than in normal mucosa. The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found that DEFAs were closely related to hsa05202: transcriptional misregulation in cancer and Hsa04015: Rap1 signaling pathway. DEFA5 may be a stable and good prognostic marker, and DEFA6 may be a poor prognostic marker in CRC of metastasis.ConclusionOverall, DEFA5 and DEFA6 have a certain degree of sensitivity and specificity in predicting CRC.

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Defensin alpha 6 (DEFA6) is a prognostic marker in colorectal cancer

Cited by 11 publications

References 25 publications

Protective Role of Spermidine in Colitis and Colon Carcinogenesis

Protective Role of Spermidine in Colitis and Colon Carcinogenesis

Antimicrobial peptides: mechanism of action, activity and clinical potential

Comprehensive analysis of alfa defensin expression and prognosis in human colorectal cancer

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