Deferasirox pyridine solvate and its Cu(II) complex: Synthesis, crystal structure, Hirshfeld surface analysis, antimicrobial assays and antioxidant activity

Zandvakili, Tayebe; Fatemi, S. Jamil. A.; Ebrahimipour, S. Yousef; Ebrahimnejad, Hadi; Castro, Jesús; Dušek, Michal; Eigner, Václav

doi:10.1016/j.molstruc.2021.131525

Cited by 12 publications

(5 citation statements)

References 58 publications

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“…The scientific literature reports a large diversity of species concerning both metal ions and ligands available for designing such effective anti-biofilm species ranging from simple to bulky ligands and acting as unidentate to multidentate species. A variety of complexes with anti-biofilm activity, ranging from species with known antibiotics or natural products to new synthetic ligands, mainly with low toxicity and chelating ability have been developed [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , <...>…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

“…A variety of complexes with anti-biofilm activity, ranging from species with known antibiotics or natural products to new synthetic ligands, mainly with low toxicity and chelating ability have been developed [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 ,…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

“…The most recent data concerning these aspects are presented in this review, with highlights on examples of complexes with antibiotics [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ], N-heterocycle derivatives [ 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 ], Schiff bases [ 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 ], biguanides [ 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , …”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

“…Good anti-biofilm activity was demonstrated by complex [Cu(dfx)(py)] ( 31 ) (dfx: deferasirox, py: pyridine) against S. aureus and P. aeruginosa together with a strong antioxidant activity [ 98 ].…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

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Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

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Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3D ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. This review presents the progress in the development of such species and their anti-biofilm activity, as well as the contribution of biomaterials science to incorporate these complexes in composite platforms for reducing the negative impact of medical biofilms.

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Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

See 2 more Smart Citations

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

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“…Cu (II) ion is adsorbed as cations and enters the bacterial cell membrane, causing protein metabolism disorder, thus preventing cell division. [75][76][77][78][79][80] From Figure 8b (a and b), only the ligand was added to the bacterial disk; the E. coli presents the stick shape; simultaneously, after adding Cu 2+ ions, E. coli begun to shrink and destroy after 6 h due to the strong antibacterial abilities of the formed Cu (II) complexes in Figure 8b (c and d).…”

Section: Hirshfeld Surfaces Analysesmentioning

confidence: 99%

Exploring two helical centrosymmetric homotetranuclear Cu (II) bis (salamo)‐based complexes

Dou

Tong

et al. 2022

Applied Organom Chemis

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Two helical centrosymmetric homotetranuclear Cu (II) complexes, [Cu 4 (L) 2 (EtOH) 2 ](ClO 4 ) 2 Á2EtOHÁ2CHCl 3 (1) and [{Cu 4 (L) 2 (EtOH) 2 }{Cu 4 (L) 2 (HNO 3 ) 2 }] (NO 3 ) 4 Á3EtOHÁ3MeOH (2), were synthesized by the reactions of a symmetric bis (salamo)-based ligand H 3 L with Cu(ClO) 2 Á6H 2 O and Cu(NO) 3 Á3H 2 O, respectively, and certified by elemental analyses, UV-Visible absorption spectra, infrared spectra and single-crystal X-ray analysis techniques. X-ray crystal structure analyses reveal that four Cu (II) atoms of complex 1 are attached to two deprotonated ligand (L) 3À units with the help of two coordinated ethanol molecules, and then forming a helical centrosymmetric complex by H-bonding and πÁ Á Áπ interactions. While complex 2 unit cell contains two crystallographically independent but chemically identical homotetranuclear complexes (molecules A and B), eight Cu (II) atoms are coordinated by four deprotonated ligand (L) 3À units. The coordination mode of four Cu (II) atoms from molecule A is the same as complex 1; at the same time, oxygen atoms on nitrates are involved in the coordination of another four Cu (II) atoms from molecule B. The short-range interactions in complexes 1 and 2 were calculated by Hirshfeld surfaces analyses. The molecular orbital energy levels, molecular stabilities of complexes 1 and 2 were analyzed by DFT calculations. In addition, antibacterial assays were also investigated in detail.

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Synthesis of Copper and Cobalt complexes with a Hydrothermal Method and Their Applications in Antibiological Activity

Luo,

Wang,

et al. 2023

ChemistrySelect

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Two novel 2‐(1,2,4‐triazol‐1‐yl)‐4‐pyridyl acid complexes with Cu(ClO4)2 ⋅ 6H2O and Co(NO3)2 ⋅ 6H2O were synthesised and their biological activities were systematically studied in vitro. The interaction between the complex and DNA was determined by UV spectroscopy, yielding binding constants of 6.63×103 and 6.09×103, respectively. The DNA binding abilities of the complexes were also investigated using fluorescence spectroscopy, showing quenching values of 0.13 and 0.08, respectively. Agarose gel electrophoresis showed that both the copper and cobalt complexes could effectively cleave DNA. In addition, flow cytometry, cell morphology detection, and MTT assays showed that the synthesised complex induced apoptosis The experimental results show that the copper complexes have promising medicinal value as potential anticancer drugs.

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Deferasirox pyridine solvate and its Cu(II) complex: Synthesis, crystal structure, Hirshfeld surface analysis, antimicrobial assays and antioxidant activity

Cited by 12 publications

References 58 publications

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

Exploring two helical centrosymmetric homotetranuclear Cu (II) bis (salamo)‐based complexes

Synthesis of Copper and Cobalt complexes with a Hydrothermal Method and Their Applications in Antibiological Activity

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