Defining and Predicting Early Recurrence after Resection for Gallbladder Cancer

Sahara, Kota; Tsilimigras, Diamantis I.; Kikuchi, Yutaro; Ethun, Cecilia G.; Maithel, Shishir K.; Abbott, Daniel E.; Poultsides, George A.; Hatzaras, Ioannis; Fields, Ryan C.; Weiss, Matthew J.; Scoggins, Charles R.; Isom, Chelsea A.; Idrees, Kamran; Shen, Perry; Yabushita, Yasuhiro; Matsuyama, Ryusei; Endo, Itaru; Pawlik, Timothy M.

doi:10.1245/s10434-020-09108-y

Cited by 27 publications

(17 citation statements)

References 35 publications

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“…10,22 Sahara et al evaluated patients with GBC with T1-T4 disease and found that major hepatectomy was a prognostic factor for early recurrence when compared with minor hepatectomy involving segments IVB/V. 12 In our cohort, however, major hepatectomy failed to remain a risk factor of early recurrence for patients with GBC with T1b-T3 disease. This inconsistency could reflect the variation in patient selection.…”

Section: Discussionmentioning

confidence: 51%

“…Besides, a subset of patients with stage T1b–T2 disease underwent hepatic wedge resection in our institute, whereas in the study by Sahara et al, minor hepatectomy referred solely to resection of IVB/V segments. 12 Kwon et al 24 demonstrated that patients with T2 lesions who had wedge resection of liver tissue around the gallbladder bed had comparable long-term survival to those who underwent resection of hepatic IVB/V segments. Therefore, wedge resection and resection of IVB/V segments were classified as “partial hepatectomy” in our study, and patients who underwent partial hepatectomy had a similar prevalence of early recurrence as those who had major hepatectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have revealed the impact of early recurrence on the prognosis of numerous hepatobiliary cancers, such as hepatocellular carcinoma, cholangiocarcinoma, and pancreatic carcinoma. [9][10][11] Sahara et al 12 reported that early recurrence impaired the prognosis of patients with GBC with stage T1-T4 after R0/R1 resection. Kota et al proposed a scoring system incorporating the T stage, margin status, differentiation, and type of liver resection for recurrence prediction.…”

Section: Introductionmentioning

confidence: 99%

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Prediction of Early Recurrence After R0 Resection for Gallbladder Carcinoma of Stage T1b–T3

Peng¹,

Nie²,

Li³

et al. 2022

CMAR

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The time-to-tumor recurrence can predict the prognosis of hepatobiliary cancers following curative-intent resection. Therefore, for patients with gallbladder carcinoma (GBC) of stage T1b-T3 who had undergone R0 resection, we investigated the risk factors for early recurrence of GBC and their prognosis. Patients and Methods: A total of 260 patients with GBC with T1b-T3 disease and an R0 margin were identified. Their clinicopathologic characteristics, perioperative details and prognostic data were reviewed. Survival analyses were carried out using the Kaplan-Meier method. Logistic regression models were used to identify the risk factors for early recurrence. Results:The optimal cutoff for early recurrence was 29 months. Early recurrence tended to result in relapse far from the primary tumor, and such patients tended to have significantly worse overall survival. Multivariate analysis revealed that T3 disease, N1/N2 stage, poor differentiation of tumor, and lymphovascular invasion (LI) were associated with a greater risk of early recurrence. Patients diagnosed as having GBC incidentally and who had the risk factors of early recurrence were more likely to benefit from re-resection 2-4 weeks after a cholecystectomy. Conclusion: T3 stage, N1-N2 stage, poor differentiation, and LI were independent risk factors associated with early recurrence for patients with GBC with stage T1b-T3 disease after R0 resection.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prediction of Early Recurrence After R0 Resection for Gallbladder Carcinoma of Stage T1b–T3

Peng¹,

Nie²,

Li³

et al. 2022

CMAR

View full text Add to dashboard Cite

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“…Sahara et al developed the GBC recurrence risk (GBRR) score to predict early recurrence within 12 months using 309 cases from the US Extrahepatic Biliary Malignancy Consortium database. The risk of early recurrence can be evaluated from high to low by inputting preoperative CA19‐9, with or without hemihepatectomy, T stage, and histological grade (12‐month RFS; low risk: 88.4%, intermediate risk: 77.9%, high risk: 37.0%) 23 . The above factors should be used to develop resectability criteria in the future.…”

Section: Surgical Treatmentmentioning

confidence: 99%

Essential updates 2019/2020: Surgical treatment of gallbladder cancer

Matsuyama

Yabusita

Homma

et al. 2021

Annals of Gastroent Surgery

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Gallbladder cancer is a biliary tract cancer that originates in the gallbladder and cystic ducts and is recognized worldwide as a refractory cancer with early involvement of the surrounding area because of its anatomical characteristics. Although the number of cases is increasing steadily worldwide, the frequency of this disease remains low, making it difficult to plan large‐scale clinical studies, and there is still much discussion about the indications for surgical resection and the introduction of multidisciplinary treatment. Articles published between 2019 and 2020 were reviewed, focusing mainly on the indications for surgical resection for each tumor stage, the treatment of incidental gallbladder cancer, and current trends in minimally invasive surgery for gallbladder cancer.

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“…The timing of recurrence may be a particularly important factor relative to long-term survival. Specifically, patients with other types of hepatopancreatobiliary (HPB) tumors such as hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and gallbladder cancer who recurred within 12–24 months of resection had a very poor overall survival [ 13 , 14 , 15 ]. To date, the impact of early recurrence (ER) after curative-intent resection for pNETs has not been well investigated.…”

Section: Introductionmentioning

confidence: 99%

Identifying Risk Factors and Patterns for Early Recurrence of Pancreatic Neuroendocrine Tumors: A Multi-Institutional Study

Heidsma

Tsilimigras

Rocha

et al. 2021

Cancers

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Background: Identifying patients at risk for early recurrence (ER) following resection for pancreatic neuroendocrine tumors (pNETs) might help to tailor adjuvant therapies and surveillance intensity in the post-operative setting. Methods: Patients undergoing surgical resection for pNETs between 1998–2018 were identified using a multi-institutional database. Using a minimum p-value approach, optimal cut-off value of recurrence-free survival (RFS) was determined based on the difference in post-recurrence survival (PRS). Risk factors for early recurrence were identified. Results: Among 807 patients who underwent curative-intent resection for pNETs, the optimal length of RFS to define ER was identified at 18 months (lowest p-value of 0.019). Median RFS was 11.0 months (95% 8.5–12.60) among ER patients (n = 49) versus 41.0 months (95% CI: 35.0–45.9) among non-ER patients (n = 77). Median PRS was worse among ER patients compared with non-ER patients (42.6 months vs. 81.5 months, p = 0.04). On multivariable analysis, tumor size (OR: 1.20, 95% CI: 1.05–1.37, p = 0.007) and positive lymph nodes (OR: 4.69, 95% CI: 1.41–15.58, p = 0.01) were independently associated with ER. Conclusion: An evidence-based cut-off value for ER after surgery for pNET was defined at 18 months. These data emphasized the importance of close follow-up in the first two years after surgery.

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Defining and Predicting Early Recurrence after Resection for Gallbladder Cancer

Cited by 27 publications

References 35 publications

Prediction of Early Recurrence After R0 Resection for Gallbladder Carcinoma of Stage T1b–T3

Prediction of Early Recurrence After R0 Resection for Gallbladder Carcinoma of Stage T1b–T3

Essential updates 2019/2020: Surgical treatment of gallbladder cancer

Identifying Risk Factors and Patterns for Early Recurrence of Pancreatic Neuroendocrine Tumors: A Multi-Institutional Study

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