2024
DOI: 10.1101/2024.01.16.575925
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Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

Youxi Liu,
Meimei Yin,
Xiaoting Mao
et al.

Abstract: Allergic contact dermatitis (ACD), a prevalent inflammatory skin disease, is elicited upon repeated skin contact with protein-reactive chemicals through a complex and poorly characterized cellular network between immune cells and skin resident cells. Here, single-cell transcriptomic analysis of the murine hapten-elicited model of ACD reveals that upon elicitation of ACD, infiltrated CD4+or CD8+lymphocytes were primarily the IFNγ-producing type 1 effector phenotype. In contrast, type 2 cytokines (IL4 and IL13) … Show more

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