As an important means to deal with crisis, organizational resilience has attracted the attention of academia and industry. However, research on what factors influence organizational resilience has lagged behind. In view of this, this study proposes the concept of organizational resilience on the basis of existing research and extracts the influencing factors of organizational resilience based on a multi-case analysis approach, using the organizational behavior of five companies in crisis situations as the research object. Based on the Interpretive Structure Model (ISM), the internal logical relationship and hierarchical structure of the factors influencing organizational resilience are analyzed. In this study, the importance of influencing factors of organizational resilience was analyzed by using analytic network process (ANP). It is suggested that strengthening organizational resilience is the key, organizational learning is the important basis, emotion management is the necessary condition, and organizational resources are the basic guarantee, which provides theoretical supplement and practical guidance for the study of organizational resilience.