Defining genomic, transcriptomic, proteomic, epigenetic, and phenotypic biomarkers with prognostic capability in male breast cancer: a systematic review

Chatterji, Subarnarekha; Krzoska, Emma; Thoroughgood, Christopher W; Saganty, John; Liu, Peng; Elsberger, Beatrix; Abu-Eid, Rasha; Speirs, Valerie

doi:10.1016/s1470-2045(22)00633-7

Cited by 18 publications

(21 citation statements)

References 96 publications

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“…Epigenetic modification, which alters gene expression by introducing chemical modifications, is an important form of epigenetic regulation. This includes histone modification, DNA modification, and RNA modification 117 . TP53‐associated H3K9 and H3K14 acetylation promotes TP53 transcription, 118 while monomethylation on H4K20 represses TP53 transcription by inhibiting nucleosome depolymerization 119,120 .…”

Section: The Structure Mutation and Modification Of P53mentioning

confidence: 99%

“…This includes histone modification, DNA modification, and RNA modification. 117 TP53‐associated H3K9 and H3K14 acetylation promotes TP53 transcription, 118 while monomethylation on H4K20 represses TP53 transcription by inhibiting nucleosome depolymerization. 119 , 120 High levels of H2B ubiquitination are often associated with DNA repair.…”

Section: The Structure Mutation and Modification Of P53mentioning

confidence: 99%

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Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies

Shen¹,

Wang²,

Mao³

et al. 2023

MedComm

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Tumor suppressor p53 can transcriptionally activate downstream genes in response to stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis, and other biological responses. p53 has seven functional domains and 12 splice isoforms, and different domains and subtypes play different roles. The activation and inactivation of p53 are finely regulated and are associated with phosphorylation/acetylation modification and ubiquitination modification, respectively. Abnormal activation of p53 is closely related to the occurrence and development of cancer. While targeted therapy of the p53 signaling pathway is still in its early stages and only a few drugs or treatments have entered clinical trials, the development of new drugs and ongoing clinical trials are expected to lead to the widespread use of p53 signaling‐targeted therapy in cancer treatment in the future. TRIAP1 is a novel p53 downstream inhibitor of apoptosis. TRIAP1 is the homolog of yeast mitochondrial intermembrane protein MDM35, which can play a tumor‐promoting role by blocking the mitochondria‐dependent apoptosis pathway. This work provides a systematic overview of recent basic research and clinical progress in the p53 signaling pathway and proposes that TRIAP1 is an important therapeutic target downstream of p53 signaling.

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Section: The Structure Mutation and Modification Of P53mentioning

confidence: 99%

Section: The Structure Mutation and Modification Of P53mentioning

confidence: 99%

Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies

Shen¹,

Wang²,

Mao³

et al. 2023

MedComm

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“…3n), potentially reflecting a variable composition of luminal epithelial sub-groups in the male gland compared to the female. Understanding the balance between AR and ER alpha expression in the male mammary gland is important because the vast majority of male breast cancer is ER positive (Cardoso et al, 2018;Chatterji et al, 2023). Mean progesterone receptor expression is higher in pubertal females than neutered males (Fig.…”

Section: Neutering Decreases Mammary Androgen Receptor Expression In ...mentioning

confidence: 99%

“…Prevalence of male breast cancer is increasing globally (Fox et al, 2022) and the risk of death is significantly higher than comparable female breast cancers (Liu et al, 2018). Male breast neoplasms also have different biology compared to breast neoplasms arising in women (Chatterji et al, 2023). Research focussed specifically on the male breast is currently limited by both the low availability of human samples and the lack of characterisation of appropriate animal models in which the complete male mammary structure persists postnatally.…”

Section: Introductionmentioning

confidence: 99%

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An ovine model for investigation of the microenvironment of the male mammary gland

Davies,

Crew,

Cochrane

et al. 2023

Preprint

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The specific biology of the male breast remains relatively unexplored in spite of the increasing global prevalence of male breast cancer. Delineation of the microenvironment of the male breast is restricted by the low availability of human samples and a lack of characterisation of appropriate animal models. Unlike the mouse, the male ovine gland persists postnatally. We suggest that the male ovine mammary gland constitutes a promising adjunctive model for the male human breast. In this study we evaluate the male ovine mammary gland microenvironment, comparing intact and neutered males. Assessment of the glandular histo-anatomy highlights the resemblance of the male gland to that of the neonatal female sheep and confirms the presence of rudimentary terminal duct lobular units. Irrespective of neutered status, cell proliferation in epithelial and stromal compartments is low in males, and cell proliferation in epithelial cells and in the intralobular stroma is significantly lower than in pubertal female sheep. Between 42% and 72% of the luminal mammary epithelial cells in the male gland express the androgen receptor, and expression is significantly reduced by neutering. Luminal epithelial cells within the intact and neutered male gland also express oestrogen receptor alpha, but minimal progesterone receptor expression is observed. The distrubution of mammary leukocytes within the ducts and stroma is similar in the female mammary gland of sheep and other species. Both macrophages and T lymphocytes are intercalated in the epithelial bilayer and are more abundant in the intralobular stroma than the interlobular stroma, suggesting that they may have a protective immunological function within the vestigial glandular tissue of the male sheep. Mast cells are also observed within the stroma. These cells cluster nearer the glandular tissue and are frequently located adjacent to blood vessels. The abundance of mast cells is significantly higher in intact males compared to neutered males, suggesting that hormone signalling may impact mast cell recruitment. In this study, we demonstrate the utility of the male ovine mammary gland as a model for furthering our knowledge of postnatal male mammary biology.

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Identification of MDM2 as a prognostic and immunotherapeutic biomarker in a comprehensive pan-cancer analysis: A promising target for breast cancer, bladder cancer and ovarian cancer immunotherapy

et al. 2023

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Defining genomic, transcriptomic, proteomic, epigenetic, and phenotypic biomarkers with prognostic capability in male breast cancer: a systematic review

Cited by 18 publications

References 96 publications

Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies

Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies

An ovine model for investigation of the microenvironment of the male mammary gland

Identification of MDM2 as a prognostic and immunotherapeutic biomarker in a comprehensive pan-cancer analysis: A promising target for breast cancer, bladder cancer and ovarian cancer immunotherapy

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