In this literature review, the effect of complex antioxidant therapy aimed at correcting oxidative stress, replenishing vitamin deficiencies, trace elements and low molecular weight peptides, has been studied, resulting in damage to the DNA of spermatozoa. In turn, low DNA integrity indicators are associated with a decrease in the probability of natural conception, a decrease in the fertilizing capacity of sperm, an increase in the frequency of embryonic developmental disorders and miscarriages, and an increase in the likelihood of developing cancer in neonates.