Defining the microbiome of the head and neck: A contemporary review

Samarrai, Ruwaa; Frank, Samantha; Lum, Avery; Woodis, Kristina; Weinstock, George M.; Roberts, Daniel S.

doi:10.1016/j.amjoto.2021.103224

Cited by 9 publications

(1 citation statement)

References 32 publications

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“…The microbiome of the intestinal tract is perhaps best characterized, with recent attention given to the microbiota of the head and neck. A recent review of the literature highlighted the diverse bacterial profiles discovered in anatomic subsites within the head and neck, including the sinuses, larynx, and ear [11]. Furthermore, the oral microbiome, which itself consists of over 700 unique species of bacteria, can be divided into anatomic regions with unique bacterial communities, including the dorsum of the tongue, hard palate, soft palate, subgingival plaque, and others [12].…”

Section: The Microbiome Plays a Role In Head And Neck Homeostasismentioning

confidence: 99%

Experimental Modeling of Host–Bacterial Interactions in Head and Neck Squamous Cell Carcinoma

Okolo,

Honzel,

Britton

et al. 2023

Cancers

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The microscopic species colonizing the human body, collectively referred to as the microbiome, play a crucial role in the maintenance of tissue homeostasis, immunity, and the development of disease. There is evidence to suggest associations between alterations in the microbiome and the development of head and neck squamous cell carcinomas (HNSCC). The use of two-dimensional (2D) modeling systems has made significant strides in uncovering the role of microbes in carcinogenesis; however, direct mechanistic links remain in their infancy. Patient-derived three-dimensional (3D) HNSCC organoid and organotypic models have recently been described. Compared to 2D models, 3D organoid culture systems effectively capture the genetic and epigenetic features of parent tissue in a patient-specific manner and may offer a more nuanced understanding of the role of host–microbe responses in carcinogenesis. This review provides a topical literature review assessing the current state of the field investigating the role of the microbiome in HNSCC; including in vivo and in vitro modeling methods that may be used to characterize microbiome–epithelial interactions.

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Section: The Microbiome Plays a Role In Head And Neck Homeostasismentioning

confidence: 99%