Definition, Classification, and Pathophysiology of Canine Glaucoma

Pizzirani, Stefano

doi:10.1016/j.cvsm.2015.06.002

Cited by 24 publications

(31 citation statements)

References 156 publications

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“…PLD itself may be an imperfect biomarker of abnormalities within the trabecular meshwork which cannot be assessed by standard gonioscopy. Further characterisation of these deeper outflow pathways by high-resolution ultrasonography and ultrasound biomicroscopy is required in both normal dogs and those which go on to develop PCAG (Pizzirani 2015 ). It is likely that such examination techniques will prove more sensitive indicators of an individual dog ' s risk of developing PCAG than gonioscopy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and progression of pectinate ligament dysplasia in the Welsh springer spaniel

Oliver

Ekiri

Mellersh

2016

J of Small Animal Practice

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Section: Discussionmentioning

confidence: 99%

Prevalence and progression of pectinate ligament dysplasia in the Welsh springer spaniel

Oliver

Ekiri

Mellersh

2016

J of Small Animal Practice

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“…73 Currently, however, lowering IOP is the only established medical therapy that may delay the onset and slow the progression of blindness.…”

Section: Neuroprotective Therapy In Primary Canine Glaucomamentioning

confidence: 99%

Medical Treatment of Primary Canine Glaucoma

Alario¹,

Strong

Pizzirani

2015

Veterinary Clinics of North America: Small Animal Practice

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“…Glaucoma commonly caused by anterior segment dysgenesis and high IOP is a frequent condition seen in cats and dogs (McLellan and Miller, 2011; Pizzirani, 2015). Colonies of cats and dogs with hereditary glaucoma are available (Grozdanic et al, 2010; Kuchtey et al, 2011; Narfstrom et al, 2013).…”

Section: Animal Models Of Glaucomamentioning

confidence: 99%

Biomechanical aspects of axonal damage in glaucoma: A brief review

Tamm

Ethier

Dowling

et al. 2017

Experimental Eye Research

100

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The biomechanical environment within the optic nerve head (ONH) is complex and is likely directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our understanding of this process is poor. Here we describe factors that influence ONH biomechanics, including ONH connective tissue microarchitecture and anatomy; intraocular pressure (IOP); and cerebrospinal fluid pressure (CSFp). We note that connective tissue factors can vary significantly from one individual to the next, as well as regionally within an eye, and that the understanding of ONH biomechanics is hindered by anatomical differences between small-animal models of glaucoma (rats and mice) and humans. Other challenges of using animal models of glaucoma to study the role of biomechanics include the complexity of assessing the degree of glaucomatous progression; and inadequate tools for monitoring and consistently elevating IOP in animal models. We conclude with a consideration of important open research questions/challenges in this area, including: (i) Creating a systems biology description of the ONH; (ii) addressing the role of astrocyte connective tissue remodeling and reactivity in glaucoma; (iii) providing a better characterization of ONH astrocytes and non-astrocytic constituent cells; (iv) better understanding the role of ONH astrocyte phagocytosis, proliferation and death; (v) collecting gene expression and phenotype data on a larger, more coordinated scale; and (vi) developing an implantable IOP sensor.

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Definition, Classification, and Pathophysiology of Canine Glaucoma

Cited by 24 publications

References 156 publications

Prevalence and progression of pectinate ligament dysplasia in the Welsh springer spaniel

Prevalence and progression of pectinate ligament dysplasia in the Welsh springer spaniel

Medical Treatment of Primary Canine Glaucoma

Biomechanical aspects of axonal damage in glaucoma: A brief review

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