Deformation partitioning provides insight into elastic, plastic, and viscous contributions to bone material behavior

Ferguson, Virginia L.

doi:10.1016/j.jmbbm.2009.01.004

Cited by 32 publications

(25 citation statements)

References 49 publications

(121 reference statements)

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“…Additionally, the edges of the indentation mark in the incubation stage are partially disturbed in contrast to the sharp edges in another stages. Such roughness of the indentation mark can be ascribed to the pull-out effect due to the adhesion depending on the hydration by the indenter [43][44][45]. The correction of the adhesion on protein crystals by the indenter would be required for more accurate analysis of the indentation hardness.…”

Section: Dislocations and Peierls Stressmentioning

confidence: 99%

Microindentation Hardness of Protein Crystals under Controlled Relative Humidity

et al. 2017

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Vickers microindentation hardness of protein crystals was investigated on the (110) habit plane of tetragonal hen egg-white lysozyme crystals containing intracrystalline water at controlled relative humidity. The time evolution of the hardness of the crystals exposed to air with different humidities exhibits three stages such as the incubation, transition, and saturation stages. The hardness in the incubation stage keeps a constant value of 16 MPa, which is independent of the humidity. The incubation hardness can correspond to the intrinsic one in the wet condition. The increase of the hardness in the transition and saturation stages is well fitted with the single exponential curve, and is correlated with the reduction of water content in the crystal by the evaporation. The saturated maximum hardness also strongly depends on the water content equilibrated with the humidity. The slip traces corresponding to the 110 [110] slip system around the indentation marks are observed in not only incubation but also saturation stages. It is suggested that the plastic deformation in protein crystals by the indentation can be attributed to dislocation multiplication and motion inducing the slip. The indentation hardness in protein crystals is discussed in light of dislocation mechanism with Peierls stress and intracrystalline water.

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Section: Dislocations and Peierls Stressmentioning

confidence: 99%

Microindentation Hardness of Protein Crystals under Controlled Relative Humidity

et al. 2017

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“…The latter approach measures an 'average' property of the underlying material by increasing the contact volume enough to reduce variability from factors including mineral content (Ferguson et al, 2003;Oyen et al, 2008), defects (Donnelly et al, 2006a), and the underlying tissue structure (Ferguson et al, 2003). Beyond bone structure, the mechanism of deformation and state of the tissue (i.e., dry, wet, versus plastic-embedded) also plays an important role in indentation response (Bembey et al, 2006a, b;Ferguson, 2009). The implications of pushing a small probe into a generally brittle material that may experience significant damage though the exact mechanisms of permanent deformation are unknown (Zhang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Influences of spherical tip radius, contact depth, and contact area on nanoindentation properties of bone

Paietta

Campbell

Ferguson

2011

Journal of Biomechanics

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“…The total displacement that occurs while achieving the onset of P max can be assumed to result from the combined elastic and plastic deformation (Ferguson, 2009). The final displacement (h f ), illustrated in Fig.…”

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confidence: 99%

“…2.17, is the permanent depth of penetration after the indenter is fully withdrawn. h f can be represented as the plastic deformation (he) (Bhushan & Li, 2003;Ferguson, 2009). The elastic deformation (he) can be defined as the difference between the maximum displacement and the final displacement -Floreza et al, 2013).…”

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A study of human and bovine trabecular bones using nanoindentation and quantitative backscattered electron imaging

Lin¹

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Osteoporosis is a disease with which bone progressively loses density and becomes fragile, leading to high risk of bone fracture. It is a major health issue in Australia, especially in the elderly population. Early awareness about the disease can help find effective medication and reduce bone fractures with appropriate lifestyle changes. In medical diagnosis, bone mineral density (BMD) measurement is used. However, thereare increased evidences to demonstrate that BMD measurement alone may be insufficient to detect the pathological changes in bone that caused by the disease. Therefore, it is essential to gain a more complete understanding of the bone properties and their effect on osteoporosis.Bone is a hierarchical composite material, which mainly consists of mineral apatite and organic matrix. Previous studies found that osteoporosis or aging could cause microstructural changes in trabecular bones of a proximal femur, the most common site for osteoporosis, and an increased degree of anisotropy was observed in osteoporotic bone properties. To identify the risk of fracture occurrence in the proximal femur as well as to prevent bone fracture, it is important to understand the relationship between bone mineral composition and bone mechanical properties. This thesis thus focused on the characterisation of the mechanical properties and mineral composition of trabecular bone, in order to address several key issues relating to the causes of osteoporosis, including: how does trabecular bone respond to different loading directions? how do bone cysts (which are the implication of pathological scenario due to the trabecular fracture) affect the mechanical properties and the mineral composition of trabeculae ? how does the mineral content affect the mechanical properties of trabeculae across different trabecular types and pathology scenarios ?To answer those questions, trabecular bone samples harvested from bovine and human femoral heads were prepared for testing. Nanoindentation was first used to characterise the mechanical behaviour of trabeculae and atomic force microscopy (AFM) was employed to examine the bone surface tomography. Quantitative backscattered electron imaging (qBEI) was utilized for determining the bone mineral density distribution and the mineral content.ii The results showed that at microscopic scale longitudinal trabeculae were stiffer and harder than transverse trabeculae, because those bones were more highly mineralized.Longitudinal trabeculae also exhibited greater resistance to plastic deformation. The difference in mechanical properties between longitudinal and transverse trabeculae is partially attributed to the difference in their mineral compositions. To further understand the mechanical behaviour of trabeculae, longitudinal and transverse trabeculae were tested in two orthogonal directions. Results showed that both longitudinal and transverse trabeculae had greater elastic modulus in axial direction than in radial direction. Because the axial loading direction is axially aligned with th...

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Deformation partitioning provides insight into elastic, plastic, and viscous contributions to bone material behavior

Cited by 32 publications

References 49 publications

Microindentation Hardness of Protein Crystals under Controlled Relative Humidity

Microindentation Hardness of Protein Crystals under Controlled Relative Humidity

Influences of spherical tip radius, contact depth, and contact area on nanoindentation properties of bone

A study of human and bovine trabecular bones using nanoindentation and quantitative backscattered electron imaging

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