Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Jia, Ben; Huang, Heyuan; Dong, Zhicheng; Ren, Xiaoyang; Lu, Yanyan; Wang, Wenzhi; Zhou, Shaowen; Zhao, Xin; Guo, Baolin

doi:10.1039/d3cs00923h

Cited by 30 publications

(1 citation statement)

References 401 publications

(349 reference statements)

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“…In recent years, with the growing emphasis on environmental protection, polymer chemistry is moving towards sustainability, which includes the development of environmentally friendly production processes and the use of renewable feedstocks instead of fossil fuel sources [28][29][30][31]. Various research teams are already working on preparing novel raw materials from renewable sources and using them to produce new materials [32].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Graft Copolymers with Poly(ε-caprolactone) Side Chain Using Hydroxylated Poly(β-myrcene-co-α-methyl styrene)

Li,

Zhang,

et al. 2024

Molecules

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Graft copolymers have unique application scenarios in the field of high-performance thermoplastic elastomers, resins and rubbers. β-myrcene (My) is a biomass monomer derived from renewable plant resources, and its homopolymer has a low glass transition temperature and high elasticity. In this work, a series of tapered copolymers P(My-co-AMS)k (k = 1, 2, 3) were first synthesized in cyclohexane by one-pot anionic polymerization of My and α-methyl styrene (AMS) using sec-BuLi as the initiator. PAMS chain would fracture when heated at high temperature and could endow the copolymer with thermal degradation property. The effect of the incorporation of AMS unit on the thermal stability and glass transition temperature of polymyrcene main chain was studied. Subsequently, the double bonds in the linear copolymers were partially epoxidized and hydroxylated into hydroxyl groups to obtain hydroxylated copolymer, which was finally used to initiate the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) to synthesize the graft copolymer with PCL as the side chain. All these copolymers before and after modifications were characterized by proton nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), thermogravimetry analysis (TGA), and differential scanning calorimeter (DSC).

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Graft Copolymers with Poly(ε-caprolactone) Side Chain Using Hydroxylated Poly(β-myrcene-co-α-methyl styrene)

Li,

Zhang,

et al. 2024

Molecules

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Recent Progress in Biomedical Scaffold Fabricated via Electrospinning: Design, Fabrication and Tissue Engineering Application

Cheng,

Song,

et al. 2024

Adv Funct Materials

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Electrospinning is a significant manufacturing strategy to create micro/nanofiber platforms that can be considered a biomedical scaffold for tissue engineering repair and regeneration. In recent years researchers have continuously broadened the equipment design and materials development of electrospinning nanofiber platforms (ENPs), which have evolved from single‐needle to multi‐needle for creating 3D ENPs, to diversify their application including the drugs/cell/growth factors release, anti‐bacterial and anti‐inflammatory, hemostasis, wound healing, and tissue repair and regeneration. Herein, multifunctional ENPs scaffold with bioactive polymer fabricated via electrospinning in terms of novel material design, construction of various structures, and various requirements in different tissue engineering regeneration are reviewed. Furthermore, this review delves into recent advancements in tissue repair facilitated by ENPs, highlighting their effectiveness and versatility across various tissue types such as bone, cartilage, tendons, cardiac tissue, and nerves. The discussion comprehensively addresses ongoing challenges in material selection, biodegradation mechanisms, bioactivation strategies, and manufacturing techniques specific to tissue repair applications. Moreover, the review outlines potential future research avenues aimed at enhancing ENPs‐based approaches in tissue engineering. This in‐depth analysis aims to provide nuanced insights and technical recommendations to propel the field of ENPs forward in tissue repair and regeneration.

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Biodegradable Citrate‐Based Polymers Enable 5D Monitoring of Implant Evolution

Shan,

Wang,

et al. 2024

Adv Funct Materials

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Biodegradable tissue engineering scaffolds have garnered increasing interest for their role in providing mechanical support, promoting tissue regeneration, and eliminating the need for removal. However, the in vivo degradation processes remain challenging to track. Here, a novel biodegradable polymer, N‐methyldiethanolamine (MDEA) and Gadolinium(III) diethylenetriamine pentaacetate (Gd‐DTPA) modified biodegradable photoluminescent polymers (BPLPMGd), which combines near‐infrared (NIR) fluorescence and magnetic resonance (MR) dual‐modality imaging are introduced to monitor scaffold degradation in vivo. The chemical structure of BPLPMGd is characterized and its dual‐imaging properties in vitro are evaluated. Subsequently, non‐invasive dual‐modality imaging to track the degradation of implanted BPLPMGd scaffolds is performed in a rat model, comparing these results with histological data. This approach reveals that BPLPMGd enables reliable non‐invasive tracking of the degradation, where NIR fluorescence imaging offers a qualitative and quantitative analysis of scaffold mass loss, total volume and solid content changes, while magnetic resonance imaging (MRI) details structural and morphological changes, allowing for 5D monitoring of implant degradation, including 3D structure, location, mass, volume, and geometry. The combination of these imaging modalities provides a comprehensive view of scaffold degradation, where the synergistic use of both yields results greater than either modality alone, offering unprecedented 5D information of implantable devices. This innovative approach has potential applications in regenerative engineering and beyond.

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Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Abstract: This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts in balancing degradation with tissue repair for improved applications.

Cited by 30 publications

References 401 publications

Synthesis and Characterization of Graft Copolymers with Poly(ε-caprolactone) Side Chain Using Hydroxylated Poly(β-myrcene-co-α-methyl styrene)

Synthesis and Characterization of Graft Copolymers with Poly(ε-caprolactone) Side Chain Using Hydroxylated Poly(β-myrcene-co-α-methyl styrene)

Recent Progress in Biomedical Scaffold Fabricated via Electrospinning: Design, Fabrication and Tissue Engineering Application

Biodegradable Citrate‐Based Polymers Enable 5D Monitoring of Implant Evolution

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