Degradable polymers for the future

Albertsson, Ann‐Christine; Karlsson, Sigbritt

doi:10.1002/actp.1995.010460203

Cited by 117 publications

(52 citation statements)

References 48 publications

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“…Aliphatic polyesters have excellent biodegradability, and some of them are industrially produced as biodegradable plastics. 31 Chemical synthesis of them often requires the severe reaction conditions (e.g., strong acid or base, high temperature, and/or reduced pressure), which sometimes involve environmental problems and a great amount of energy use. On the other hand, the present polymerization from using a isolated biocatalyst proceeded even under mild conditions (45°C).…”

Section: Resultsmentioning

confidence: 99%

Lipase-catalyzed polycondensation of dicarboxylic acid-divinyl esters and glycols to aliphatic polyesters

Uyama

Yaguchi

Kobayashi

1999

J. Polym. Sci. A Polym. Chem.

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Section: Resultsmentioning

confidence: 99%

Lipase-catalyzed polycondensation of dicarboxylic acid-divinyl esters and glycols to aliphatic polyesters

Uyama

Yaguchi

Kobayashi

1999

J. Polym. Sci. A Polym. Chem.

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“…The favourable characteristics of magnesium alloys are the ability to degradation, a similar elasticity modulus to bone, a stimulation effect to bone growth and good biocompatibility (Shi et al 2010, Staiger et al 2006, Xu et al 2007, Zeng et al 2008). The PCL is known for its bioabsorbability with slow degradation, and it is radiolucent and not toxic (Albertsson and Karlsson 1995, Hiljanen-Vainio et al 1996, Kronental 1975). The idea to combine these two kinds of material as a hybrid cage was to ensure a sufficient primary stability by the magnesium skeleton and to prevent too fast degradation by infiltration of the magnesium alloy with the PCL (Kauth et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Preliminary results in anterior cervical discectomy and fusion with an experimental bioabsorbable cage – clinical and radiological findings in an ovine animal model

et al. 2013

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BackgroundBioabsorbable implants are not widely used in spine surgery. This study investigated the clinical and radiological findings after anterior cervical discectomy and fusion (ACDF) in an ovine animal model with an experimental bioabsorbable cage consisting of magnesium and polymer (poly-ϵ-caprolactone, PCL) in comparison to a tricortical bone graft as the gold standard procedure.Materials and Methods24 full-grown sheep had ACDF of C3/4 and C5/6 with an experimental bioabsorbable implant (magnesium and PCL) in one level and an autologous tricortical bone graft in the second level. The sheep were divided into 4 groups (6 sheep each). After 3, 6, 12, or 24 weeks postoperatively, the cervical spines were harvested and conventional x-rays of each operated segment were conducted. The progress of interbody fusion was classified according to a three-point scoring system.ResultsThere were no operation related complications except for one intraoperative fracture of the anterior superior iliac spine and two cases of screw loosening and sinking, respectively. In particular, no vascular, neurologic, wound healing or infectious problems were observed. According to the time of follow-up, both interbody fusion devices showed similar behaviour with increasing intervertebral osseointegration and complete arthrodesis in 10 of 12 (83.3%) motion segments after 24 weeks.ConclusionsThe bioabsorbable magnesium-PCL cage used in this experimental animal study showed clinically no signs of incompatibility such as infectious or wound healing problems. The radiographic results regarding the osseointegration are comparable between the cage and the bone graft group.

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“…Starch graft copolymer is a representative of the modification of the starch molecule by chemical method. Modified starch has a wide range of applications, from biodegradable packaging material to components of oil-drilling mud [9]. Modified starches were used as thickeners and gelling agents.…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery

Simi

Abraham

2007

Bioprocess Biosyst Eng

203

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The synthesis of modified hydrophobic starch nanoparticles using long chain fatty acids was accomplished. Grafting of fatty acid on the starch was done using potassium persulphate as catalyst and the formation of graft polymer was confirmed by FTIR spectra. The thermal properties of the native and grafted starch were investigated using simultaneous TG-DTA and DSC. The graft polymerization was found to be depending on the temperature and the duration of the reaction. The modified starch nanoparticles were cross-linked with sodium tripoly phosphate for better stabilization. Morphology of the grafted starch nanoparticles was studied by SEM and AFM. Drug-loading and the controlled release of the drug from the nanoparticles was studied using indomethacin as model drug.

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Degradable polymers for the future

Cited by 117 publications

References 48 publications

Lipase-catalyzed polycondensation of dicarboxylic acid-divinyl esters and glycols to aliphatic polyesters

Lipase-catalyzed polycondensation of dicarboxylic acid-divinyl esters and glycols to aliphatic polyesters

Preliminary results in anterior cervical discectomy and fusion with an experimental bioabsorbable cage – clinical and radiological findings in an ovine animal model

Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery

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