Degradation studies on segmented polyurethanes prepared with poly (d, l-lactic acid) diol, hexamethylene diisocyanate and different chain extenders

Wang, Yuanliang; Ruan, Changshun; Sun, Jiaoxia; Zhang, Maolan; Wu, Yanglan; Peng, Kun

doi:10.1016/j.polymdegradstab.2011.06.015

Cited by 48 publications

(42 citation statements)

References 24 publications

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“…A weak peak at 1734 cm −1 belonged to carbonyl (–CO) of PCL blocks. Two weak bands at 1627 cm −1 and 1539 cm −1 corresponded to amide I and II of urethane in PCFC‐HDI chain, respectively . In addition, a strong absorption at 1117 cm −1 band and a weak peak at 567 cm −1 all belonged to PO 4 3− of n‐HA.…”

Section: Resultsmentioning

confidence: 94%

“…Two weak bands at 1627 cm 21 and 1539 cm 21 corresponded to amide I and II of urethane in PCFC-HDI chain, respectively. 26 In addition, a strong absorption at 1117 cm 21 band and a weak peak at 567 cm 21 all belonged to PO 4 32 of n-HA. Although each spectrum presented similar pattern, we still could observe the change in relative intensity of these characteristic peaks after the composite underwent different degradation time.…”

Section: Ft-ir Analysismentioning

confidence: 93%

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In vitro and in vivo degradation behavior of n‐HA/PCL‐Pluronic‐PCL polyurethane composites

Meng

Fan

et al. 2013

J Biomedical Materials Res

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Scaffolds for bone tissue engineering applications should have suitable degradability in favor of new bone ingrowth after implantation into bone defects. In this study, degradation behavior of polyurethane composites composed of triblock copolymer poly(caprolactone)-poluronic-poly(caprolactone) (PCL-Pluronic-PCL, PCFC) and nanohydroxyapatite (n-HA) was investigated. The water contact angle and water absorption were measured to reveal the effect of n-HA content on the surface wettability and swelling behavior of the n-HA/PCFC composites, respectively. The weight loss in three degradation media with pH value of 4.0, 7.4, and 9.18 was also studied accordingly. Fourier transform infrared analysis, differential scanning calorimeter, X-ray diffraction, thermal-gravimetric analysis, and scanning electron microscopy were used to investigate the change of chemical structure and micromorphology after the n-HA/PCFC composite with 30% HA was degraded for different time intervals. Meanwhile, in vivo degradation was conducted by subcutaneous implantation. The weight loss and morphology change during observation periods were also studied.

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Section: Resultsmentioning

confidence: 94%

Section: Ft-ir Analysismentioning

confidence: 93%

In vitro and in vivo degradation behavior of n‐HA/PCL‐Pluronic‐PCL polyurethane composites

Meng

Fan

et al. 2013

J Biomedical Materials Res

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“…Following the current trends, the aim is to replace petrochemical component by renewable raw materials . The use of components from renewable resources have growing attention due to exhaustion of the fossil resources and their increasing cost . ⁠In the case of PUs, the main aim is to produce bio‐polyol or bio‐isocyanate.…”

Section: Bio‐based Raw Materialsmentioning

confidence: 99%

Thermoplastic polyurethanes derived from petrochemical or renewable resources: A comprehensive review

Datta

Kasprzyk

2017

Polymer Engineering & Sci

120

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Thermoplastic polyurethanes (TPUs) materials are obtained by the reaction of polyol (ether-, ester-, and carbonate-based diols with average molecular weight in the range from 1,000 to 3,000 g/mol) with aliphatic or aromatic diisocyanates. Synthesized materials consist of the hard and soft segments which are separated in different level. All mechanical and thermal properties of TPUs depend on the chemical structure of used monomers, volume fraction, and interaction between the hard and soft segments. Presented work is the review of the synthesis and the structure-properties relationship analysis in the case of TPU. The most popular reactants used for the production of the TPUs have petrochemical-based origin.

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“…Previously 6, 21, 25 , P-PUUs have been prepared by us with poly (D, L-lactic acid) diol, hexamethylene diisocyanate (HDI) and piperazine (PP) as the chain extender (Fig. 1a).…”

Section: Introductionmentioning

confidence: 99%

The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior

Ruan

et al. 2017

Sci Rep

Self Cite

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A weak alkaline environment is established to facilitate the growth of osteoblasts. Unfortunately, this is inconsistent with the application of biodegradable polymer in bone regeneration, as the degradation products are usually acidic. In this study, the variation of the interfacial pH of poly (D, L-lactide) and piperazine-based polyurethane ureas (P-PUUs), as the representations of acidic degradable materials, and the behavior of osteoblasts on these substrates with tunable interfacial pH were investigated in vitro. These results revealed that the release of degraded products caused a rapid decrease in the interfacial pH, and this could be relieved by the introduction of alkaline segments. On the contrary, when culturing with osteoblasts, the variation of the interfacial pH revealed an upward tendency, indicating that cell could construct the microenvironment by secreting cellular metabolites to satisfy its own survival. In addition, the behavior of osteoblasts on substrates exhibited that P-PUUs with the most PP units were better for cell growth and osteogenic differentiation of cells. This is due to the hydrophilic surface and the moderate N% in P-PUUs, key factors in the promotion of the early stages of cellular responses, and the interfacial pH contributing to the enhanced effect on osteogenic differentiation.

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Degradation studies on segmented polyurethanes prepared with poly (d, l-lactic acid) diol, hexamethylene diisocyanate and different chain extenders

Cited by 48 publications

References 24 publications

In vitro and in vivo degradation behavior of n‐HA/PCL‐Pluronic‐PCL polyurethane composites

In vitro and in vivo degradation behavior of n‐HA/PCL‐Pluronic‐PCL polyurethane composites

Thermoplastic polyurethanes derived from petrochemical or renewable resources: A comprehensive review

The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior

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