Deiodinases and thyroid metabolism disruption in teleost fish

Jarque, Sergio; Piña, Benjamı́n

doi:10.1016/j.envres.2014.09.022

Cited by 67 publications

(38 citation statements)

References 172 publications

(163 reference statements)

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“…Previous studies have ruled out the likely involvement of cytochrome P450s [11,29] and suggested that deiodinase may play a role in debromination [30,31], which our results further confirmed. The absence of NADPH did not affect the capacity of crucian carp microsomes to debrominate BDE 99 (Table 2).…”

Section: Comparison Metabolism Of Pbdes In Crucian Carp and Catfishsupporting

confidence: 89%

Species‐specific and structure‐dependent debromination of polybrominated diphenyl ether in fish by in vitro hepatic metabolism

Luo

Zeng

et al. 2017

Enviro Toxic and Chemistry

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To explore the cause of species-specific differences and structure-activity relationships in the debromination of polybrominated diphenyl ethers (PBDEs) in fish, a series of in vitro measurements of hepatic metabolism of PBDE were made using crucian carp (Carassius carassius) and catfish (Silurus asotus) and the activity of deiodinase in liver microsomes was measured. Debromination was observed in the crucian carp but not in the catfish. No difference was found in total deiodinase activity despite the activity of type 1 deiodinase in crucian carp being twice that of catfish. It is difficult to determine whether the differences in deiodinase activity were responsible for the species-specific differences observed. In crucian carp, penta-brominated diphenyl ether congeners exhibited the highest debromination rates, and the transformation rate decreased with an increasing number of substituted bromines. Adjacent bromine substitution in the phenyl ring was a necessary, but insufficient, condition for debromination in crucian carp. Doubly flanked bromine was always preferentially removed, while single-flanked bromine, meta-substituted bromine, was debrominated the most, followed by para- and then ortho-bromine. No debromination was observed for single-flanked bromine when there was a symmetrical structure with (2, 4, 6) bromine substitutions in 1 phenyl ring, indicating that this structure can improve resistance to debromination metabolism. Environ Toxicol Chem 2017;36:2005-2011. © 2017 SETAC.

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Section: Comparison Metabolism Of Pbdes In Crucian Carp and Catfishsupporting

confidence: 89%

Species‐specific and structure‐dependent debromination of polybrominated diphenyl ether in fish by in vitro hepatic metabolism

Luo

Zeng

et al. 2017

Enviro Toxic and Chemistry

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“…TH signalling affects cone opsin identity during development of the model systems mice and zebrafish, but also other fish species such as rainbow trout and coho salmon (Cheng, Gan, & Flamarique, ; Ng et al., ; Suliman & Flamarique, ) and adult cone opsin expression in mice (Glaschke et al., ). The active form of the hormone, triiodothyronine (T3), is synthesized from the prohormone thyroxine (T4) by the enzyme iodothyronine deiodinase type 2 (Dio2), whereas the enzyme iodothyronine deiodinase type 3 (Dio3) catabolizes T3 (Bianco & Larsen, ; Jarque & Pina, ). Knockdown of deiodinases in zebrafish causes morphological defects of the eye and disrupted visual function (Houbrechts et al.…”

Section: Discussionmentioning

confidence: 99%

“…whereas the enzyme iodothyronine deiodinase type 3 (Dio3) catabolizes T3 (Bianco & Larsen, 2005;Jarque & Pina, 2014). Knockdown of deiodinases in zebrafish causes morphological defects of the eye and disrupted visual function (Houbrechts et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Two genes have been commonly used for this purpose, the iodothyronine deiodinase type 2 ( dio2 ) and type 3 ( dio3 ). Dio2 and Dio3 enzymes are involved in regulation of TH signalling by transforming the inactive prohormone thyroxine (T4) into the active form triiodothyronine (T3) and by catabolizing T3, respectively (Bianco & Larsen, ; Jarque & Pina, ). More importantly, TH is known to downregulate dio2 and upregulate dio3 gene expression; this has been shown in multiple teleost species (Garcia, Jeziorski, Valverde, & Orozco, ; Johnson & Lema, ; Marlatt et al., ) as well as other vertebrates (reviewed in Gereben, Zeold, Dentice, Salvatore, & Bianco, ; Glaschke et al., ).…”

Section: Methodsmentioning

confidence: 99%

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Rapid adaptation to a novel light environment: The importance of ontogeny and phenotypic plasticity in shaping the visual system of Nicaraguan Midas cichlid fish (Amphilophus citrinellus spp.)

2017

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Colonization of novel habitats is typically challenging to organisms. In the initial stage after colonization, approximation to fitness optima in the new environment can occur by selection acting on standing genetic variation, modification of developmental patterns or phenotypic plasticity. Midas cichlids have recently colonized crater Lake Apoyo from great Lake Nicaragua. The photic environment of crater Lake Apoyo is shifted towards shorter wavelengths compared to great Lake Nicaragua and Midas cichlids from both lakes differ in visual sensitivity. We investigated the contribution of ontogeny and phenotypic plasticity in shaping the visual system of Midas cichlids after colonizing this novel photic environment. To this end, we measured cone opsin expression both during development and after experimental exposure to different light treatments. Midas cichlids from both lakes undergo ontogenetic changes in cone opsin expression, but visual sensitivity is consistently shifted towards shorter wavelengths in crater lake fish, which leads to a paedomorphic retention of their visual phenotype. This shift might be mediated by lower levels of thyroid hormone in crater lake Midas cichlids (measured indirectly as dio2 and dio3 gene expression). Exposing fish to different light treatments revealed that cone opsin expression is phenotypically plastic in both species during early development, with short and long wavelength light slowing or accelerating ontogenetic changes, respectively. Notably, this plastic response was maintained into adulthood only in the derived crater lake Midas cichlids. We conclude that the rapid evolution of Midas cichlids' visual system after colonizing crater Lake Apoyo was mediated by a shift in visual sensitivity during ontogeny and was further aided by phenotypic plasticity during development.

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“…). Specifically, iodothyronine deiodinases have been shown to control developmental phases in teleost fishes (e.g., Jarque and Piña ). Kawakami et al.…”

Section: Discussionmentioning

confidence: 99%

River‐Specific Gene Expression Patterns Associated with Habitat Selection for Key Hormone‐Coding Genes in Glass Eel‐Stage American Eels

et al. 2018

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The glass eel stage of the American Eel Anguilla rostrata marks the onset of the catadromous migration into estuarine or freshwater habitats, and the endocrine mechanisms underlying this habitat selection are still not well understood. Using a candidate genes approach, the aim of this study was to test for different patterns of gene expression related to (1) salinity preferences and/or (2) capture site to predict physiological differences between migratory behaviors. We performed analyses revealing the expression of genes coding for key hormonal factors or their receptors on glass eel‐stage American Eels collected at the mouths of three rivers on the east coast of Canada (Grande‐Rivière‐Blanche, St. Lawrence estuary; Rivière‐Saint‐Jean, Gaspé Peninsula; and the Mersey River, Nova Scotia); eels from the three systems displayed different salinity preferences (brackish water/salt water/freshwater) under laboratory conditions. Transcripts from genes coding for prolactin (PRL), thyroid‐stimulating hormone β subunit, type‐2 iodothyronine deiodinase (DIO‐2), thyroid hormone receptors αa and αb (THRαa and THRαb), growth hormone (GH), insulin‐like growth factor 1 (IGF‐1), and their respective receptors (GH‐R1 and IGF‐1R) were all detected in glass eels. No differences in the expression patterns were detected pertaining to salinity preference, but strong differences were found among rivers. Rivière‐Saint‐Jean glass eels, which were the longest and the least pigmented among the three rivers, were characterized by the highest expression of PRL, DIO‐2, and THRαb. Those from Grande‐Rivière‐Blanche showed an increase in IGF‐1R. Glass eels captured from these two rivers also exhibited the highest expression of GH and GH‐R1. Overall, these results confirm gene × environment interactions at the gene expression level when glass eels settle into their continental habitat. As such, our results also support the concept of the presence of different ecotypes in the Atlantic Canadian coast and in the estuary and Gulf of St. Lawrence.

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Deiodinases and thyroid metabolism disruption in teleost fish

Cited by 67 publications

References 172 publications

Species‐specific and structure‐dependent debromination of polybrominated diphenyl ether in fish by in vitro hepatic metabolism

Species‐specific and structure‐dependent debromination of polybrominated diphenyl ether in fish by in vitro hepatic metabolism

Rapid adaptation to a novel light environment: The importance of ontogeny and phenotypic plasticity in shaping the visual system of Nicaraguan Midas cichlid fish (Amphilophus citrinellus spp.)

River‐Specific Gene Expression Patterns Associated with Habitat Selection for Key Hormone‐Coding Genes in Glass Eel‐Stage American Eels

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