Delay of the Denervation Process in Skeletal Muscle by Sensory Ganglion Graft and Its Clinical Application

Ochi, Mitsuo; Kwong, Wing-Hang; Kimori, Kenji; Takemoto, Shozui; Chow, S. P.; Ikuta, Yoshikazu

doi:10.1097/00006534-199603000-00014

Cited by 17 publications

(11 citation statements)

References 27 publications

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“…We and others have previously reported the beneficial effects of sensory-to-motor nerve repair, ''sensory protection'', [10][11][12][13][14][15][16][17][18][19][20][21] in preserving both distal nerve and muscle integrity and function. Sensory protection preserves muscle weight, histologic features, 20 and muscle function 21 following denervation.…”

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confidence: 99%

Contribution of the Distal Nerve Sheath to Nerve and Muscle Preservation Following Denervation and Sensory Protection

Veltri¹,

Kwiecień²,

Minet

et al. 2005

J reconstr Microsurg

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The goal of this study was to determine the contribution of the distal nerve sheath to sensory protection. Following tibial nerve transection, rats were assigned to one of the following groups: (1) saphenous-to-tibial nerve neurorrhaphy; (2) saphenous-to-gastrocnemius neurotization; (3) unprotected controls (tibial nerve transection); or (4) immediate common peroneal-to-tibial nerve neurorrhaphy. After a 6-month denervation period and motor reinnervation, ultrastructural, histologic, and morphometric analyses were performed on the distal tibial nerve and gastrocnemius muscle cross-sections. Sensory axons neurotized to muscle maintain existing muscle integrity, as demonstrated by less fibrosis, collagenization, and fat deposition, more than unprotected muscle, and preserve the distribution pattern of fast twitch fibers. However, neurorrhaphy of the sensory nerve to the distal tibial nerve (involving the distal nerve sheath) improves existing endoneurial sheath structure, demonstrated by reduced collagen, and enhances regeneration, shown by improved axon-to-Schwann cell coupling and increased axon area. The authors conclude that sensory protection of muscle does not require the distal nerve sheath, but that preservation of the distal sheath may contribute to enhanced nerve regeneration.

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confidence: 99%

Contribution of the Distal Nerve Sheath to Nerve and Muscle Preservation Following Denervation and Sensory Protection

Veltri¹,

Kwiecień²,

Minet

et al. 2005

J reconstr Microsurg

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“…It was suggested that percentage values minimize variations between animals and are more useful than absolute values for comparisons among groups. [16][17][18] Analysis of variance (ANOVA) was used to evaluate differences between group means. A P value of 0.05 was accepted for statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Long‐term evaluation of rabbit peripheral nerve repair with end‐to‐side neurorrhaphy in rabbits

et al. 2006

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This study was designed to quantitatively assess long-term end-to-side neurorrhaphy in rabbits. The cut right ulnar nerve was repaired and sutured to the median nerve, in which a perineurial window was created in an end-to-side fashion 3 cm above the elbow joint. Both the extent of the reinnervation and the integrity of the intact donor nerve were evaluated in 36 rabbits randomly treated with fresh or delayed nerve repair. Evaluations included motor nerve conduction velocity (MNCV), dry muscle weight (DMW), and histological examinations at 9 and 12 months postoperatively. The recovery rates of MNCV were 90.1% and 92.8% for the ulnar nerve, and 95.7% and 96.8% for the median nerve, compared to intact contralateral nerves at 9 and 12 months, respectively. MNCV was not detectable for the ulnar nerve in control animals, while it was normal for the median nerve. Recoveries of flexor carpi ulnaris dry muscle weight of about 90.7% and 94.5% were observed at 9 and 12 months postoperatively, respectively. However, muscle mass measurements revealed a recovery of only 31.3% and 27% for control groups at 9 and 12 months postoperatively. The differences between experimental groups and control groups were statistically significant (P < 0.01). Neurofilament and silver stains showed numerous sprouting axons originating from the median nerve to the ulnar nerve. The results indicate that end-to-side neurorrhaphy could induce axonal sprouting from the main nerve trunk of upper limbs in rabbits, leading to useful functional recovery.

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“…It was suggested that percentage values minimize variations between animals and are more useful than absolute values for comparison among groups. [16][17][18] Analysis of variance (ANOVA) was used to evaluate differences between group means. A P value of 0.05 was accepted for statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Repair of the main nerve trunk of the upper limb with end‐to‐side neurorrhaphy: An experimental study in rabbits

et al. 2006

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The aim of this study was to assess the effectiveness of reinnervation using end-to-side neurorrhaphy in the upper extremity of the rabbit. The cut right ulnar nerve was repaired and sutured to the side of the median nerve about 3 cm above the elbow joint. The extent of reinnervation was quantitatively evaluated, as well as the integrity of the intact donor nerve in 36 rabbits randomly treated with fresh or delayed nerve repair with or without perineurotomy. Evaluations included nerve conduction velocity (NCV) of both the ulnar and medial nerves, dry muscle weight, and histologic examination (neurofilament stain and morphometric assessment) at 3 and 6 months postoperatively. NCV recovery rates were 79% and 87% for the ulnar nerve, and 89% and 94% for the median nerve compared to contralateral intact nerves, at 3 and 6 months, respectively. Flexor carpi ulnaris muscle mass measurements revealed a recovery in dry muscle weight of about 81% and 88% at 3 and 6 months, respectively, compared to the intact contralateral flexor carpi ulnaris. Histologic studies with neurofilament staining reveal numerous axonal sprouts at the distal end of the median nerve, indicative of myelinated axonal regeneration. Morphometric analysis demonstrated no difference between fresh and delayed repairs. These results indicate that in the upper extremity of rabbits, end-to-side neurorrhaphy permits axonal regeneration from the intact donor nerve, and is associated with satisfactory recovery. The effect of the procedure on the donor nerve was negligible.

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Delay of the Denervation Process in Skeletal Muscle by Sensory Ganglion Graft and Its Clinical Application

Cited by 17 publications

References 27 publications

Contribution of the Distal Nerve Sheath to Nerve and Muscle Preservation Following Denervation and Sensory Protection

Contribution of the Distal Nerve Sheath to Nerve and Muscle Preservation Following Denervation and Sensory Protection

Long‐term evaluation of rabbit peripheral nerve repair with end‐to‐side neurorrhaphy in rabbits

Repair of the main nerve trunk of the upper limb with end‐to‐side neurorrhaphy: An experimental study in rabbits

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