Delayed cerebellar ataxia induced by <i>Plasmodium falciparum</i> malaria: A rare complication

Siddig, Emmanuel Edwar; Misbah El‐Sadig, Sarah; Eltigani, Hala Fathi; Musa, Ahmed Mudawi; Mohamed, Nouh Saad; Ahmed, Ayman

doi:10.1002/ccr3.8053

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Therefore, initiating a national Preparedness and Response strategic plan was aimed at early detection, prevention and control of the country-wide spread of the Mpox outbreak given the country's poorly structured and severely under-supported healthcare system and has not yet recovered from the COVID-19 pandemic [35]. The lack of resources and the increasing burden of other infectious diseases, including viral diseases [36][37][38][39], parasitic [33,[40][41][42] and bacterial infections [43], could potentially exacerbate the situation. Despite these challenges, the prompt implementation of an integrated surveillance and response system has helped in the containment of the outbreak and prevented the further spread of Mpox highlighting the effectiveness of prompt response through quickly isolating the suspected cases and providing supportive treatment for confirmed cases [44,45].…”

Section: Discussionmentioning

confidence: 99%

Preparedness, Prevention, Investigation, and Response to the Emergence of Mpox in Khartoum, Sudan in 2022

Ali,

Siddig,

Osman

et al. 2024

Preprint

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Mpox, formerly known as Monkeypox, is a rare viral disease initially discovered in Africa in 1958. Since its first identification, several outbreaks have occurred in various African nations. Recently, the global community has witnessed a resurgence in the number of Mpox cases reported worldwide, prompting the World Health Organization (WHO) to declare the ongoing multi-country outbreak a public health emergency in July 2022. This study reports on the first cases of Mpox detected in Khartoum State, Sudan, outlining the epidemiology, preparedness, and public health response to this new challenge. A total of 55 suspected cases were identified, with two confirmed cases. The clinical manifestations observed in these cases align with the classic skin rash typical of Mpox, presenting alongside symptoms like fever, headache, and joint pain. The findings underscore the need for heightened surveillance, early detection, and timely intervention to prevent the domestic spread of Mpox and its potential impact on public health. Continued global efforts are needed to support effective screening, diagnostic, and control measures, ultimately enhancing preparedness and response in the face of this emerging disease.

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Section: Discussionmentioning

confidence: 99%

Preparedness, Prevention, Investigation, and Response to the Emergence of Mpox in Khartoum, Sudan in 2022

Ali,

Siddig,

Osman

et al. 2024

Preprint

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The challenge of triple intestinal parasite infections in immigrants—A call for comprehensive differential diagnosis

Siddig,

Ahmed

2024

Clinical Case Reports

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Key Clinical MessageScreening for parasitic infections among displaced populations including migrants, refugees, and internally displaced persons is crucial to prevent long‐term complications associated with untreated infections. Additionally, prompt treatment with appropriate medications like praziquantel and albendazole can lead to significant improvement and successful patient outcomes. This case highlights the necessity of heightened awareness, early detection, and effective management of parasitic infections to enhance public health efforts and minimize the spread of these diseases. Implementing multisectoral One Health will improve human, animal, and environmental health globally using limited resources.AbstractParasitic infections including Schistosoma spp., hookworm, and Strongyloides spp. are commonly co‐existing diseases in underdeveloped countries including South Sudan and Sudan. These infections are often presented with no specific symptoms, therefore they remain undetected and eventually leading to long‐term complications. Latent parasitic infections among adults particularly displaced population like migrants and refugees have recently gained global attention. In this case report, we present the case of a young male immigrant from South Sudan with multi‐parasitic infections. The patient was admitted to a hospital complaining of gastrointestinal symptoms of hematemesis and melena, which were accompanied by signs of liver and spleen enlargement, coupled with low blood cell counts. While liver function tests showed no abnormalities, stool examinations confirmed the presence of S. mansoni, hook worm eggs, and Rhabditiform first‐stage larvae of S. stercoralis. The patient was treated with medications such as praziquantel and albendazole, which resulted in full recovery and discharge from the hospital. This case highlights the importance of considering multiple infections among patients with gastrointestinal symptoms, especially in endemic areas. Cost‐effective prevention and control strategy require the implementation of a multisectoral One Health strategy for the surveillance, prevention, and control of parasitic infections in human, animals, and the environment.

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High seroprevalence of yellow fever, dengue, and chikungunya viruses in the Greater Darfur region of Sudan: Implications for national health policy and surveillance

Mohamed,

Siddig,

Musa

et al. 2024

Preprint

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Objectives Arboviruses pose a significant global health challenge. This study investigated the seroprevalence of major human arboviral infections, including yellow fever (YFV), dengue (DENV), Crimean-Congo hemorrhagic fever (CCHF), Rift Valley fever (RVFV), West Nile virus (WNV), and chikungunya (CHIKV), in the Darfur region from September to December 2018. ELISA-IgM was used to detect antibodies. RT‒PCR was used to confirm YFV infection in positive IgM samples. Results A total of 152 blood samples were collected, with 123 (80.9%) from males and 29 (19.1%) from females. The participants were grouped by age: 50 (32.9%) were under 20 years, 96 (63.2%) were aged 20–45 years, and 6 (3.9%) were over 45 years. The seroprevalence rates for YFV, DENV, and CHIKV were 68 (44.7%), 23 (15.1%), and 5 (3.3%), respectively. There were 11 confirmed YFV cases (7.2%) using RT-PCR. Among these, 3/11 were positive for DENV-IgM, and 1/11 was positive for CHIKV-IgM. Among the 68 YFV-positive individuals, 15 (22.1%) had been exposed to DENV, and 2 (2.9%) had been exposed to CHIKV. Coexposure to DENV and CHIKV was detected in 3 (1.9%) patients, while 2 (1.3%) patients had triple exposure to YFV, CHIKV, or DENV. No exposure to CCHF, RVFV, or WNV was detected.

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Delayed cerebellar ataxia induced by Plasmodium falciparum malaria: A rare complication

Cited by 3 publications

References 24 publications

Preparedness, Prevention, Investigation, and Response to the Emergence of Mpox in Khartoum, Sudan in 2022

Preparedness, Prevention, Investigation, and Response to the Emergence of Mpox in Khartoum, Sudan in 2022

The challenge of triple intestinal parasite infections in immigrants—A call for comprehensive differential diagnosis

High seroprevalence of yellow fever, dengue, and chikungunya viruses in the Greater Darfur region of Sudan: Implications for national health policy and surveillance

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