Delayed Gadolinium-enhanced MR to Determine Glycosaminoglycan Concentration in Reparative Cartilage after Autologous Chondrocyte Implantation: Preliminary Results

Watanabe, Atsuya; Wada, Yuichi; Obata, Takayuki; Ueda, Toshihisa; Tamura, Mitsuru; Ikehira, Hiroo; Moriya, Hideshige

doi:10.1148/radiol.2383050173

Cited by 131 publications

(163 citation statements)

References 32 publications

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“…Using this index as a metric of GAG distribution assumes that in the absence of contrast T 1 , is relatively constant. While this generally holds for native tissue (169), it may not hold for tissue engineered or implant tissue, where the hydration may vary substantially (183). Therefore, obtaining information regarding cartilage composition depends upon measurement of MR relaxation times, T 2 , T 1rho and T 1 .…”

Section: Quantitative Measurements Of Cartilage Composition In Oamentioning

confidence: 99%

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

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Magnetic resonance imaging (MRI) and quantitative image analysis technology has recently started to generate a great wealth of quantitative information on articular cartilage and bone physiology, pathophysiology and degenerative changes in osteoarthritis. This paper reviews semiquantitative scoring of changes of articular tissues (e.g. WORMS ¼ whole-organ MRI scoring or KOSS ¼ knee osteoarthritis scoring system), quantification of cartilage morphology (e.g. volume and thickness), quantitative measurements of cartilage composition (e.g. T 2 , T 1rho , T 1Gd ¼ dGEMRIC index) and quantitative measurement of bone structure (e.g. app. BV/TV, app. TbTh, app. Tb.N, app. Tb.Sp) in osteoarthritis. For each of these fields we describe the hardware and MRI sequences available, the image analysis systems and techniques used to derive semiquantitative and quantitative parameters, the technical accuracy and precision of the measurements reported to date and current results from cross-sectional and longitudinal studies in osteoarthritis. Moreover, the paper summarizes studies that have compared MRI-based measurements with radiography and discusses future perspectives of quantitative MRI in osteoarthritis. In summary, the above methodologies show great promise for elucidating the pathophysiology of various tissues and identifying risk factors of osteoarthritis, for developing structure modifying drugs (DMOADs) and for combating osteoarthritis with new and better therapy. Copyright # 2006 John Wiley & Sons, Ltd.KEYWORDS: osteoarthritis; joint; cartilage; bone; magnetic resonance imaging; knee; image analysis; disease-modifying drugs RATIONALE FOR QUANTITATIVE MRI OF CARTILAGE AND BONE IN OSTEOARTHRITISThe health and integrity of diarthrodial (synovial) joints are prerequisites for pain-free movement and have a major impact on the quality of life. However, the population of individuals above the age of 65 years is rapidly growing and 70% of the women and 60% of the men aged 65 years or older suffer from degenerative joint disease [¼ osteoarthritis (OA)] (1-7). OA has been defined by the American College of Rheumatology (ACR) as a 'heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage, in addition to related changes in the underlying bone at the joint margins'. It remains an open question whether the initial changes take place in cartilage or bone or other articular tissues and, more importantly, what the causal relationship between these changes is (5-19). Also, within each NMR IN BIOMEDICINE NMR Biomed. 2006; 19: 822-854 Published online in Wiley InterScience (www.interscience.wiley.com). DOI:10.1002/nbm.1063 narrowing; JSW, joint space width; K, knee; KLG, Kellgren Lawrence grade; KOSS, knee osteoarthritis scoring system; LF, lateral femoral condyle; LT, lateral tibia; MRI, magnetic resonance imaging; MF, medial femoral condyle; MT, medial tibia; OA, osteoarthritis; OAI, Osteoarthritis Initiative; P, patella; PGs, proteoglycans;...

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Section: Quantitative Measurements Of Cartilage Composition In Oamentioning

confidence: 99%

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

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“…4,5 To obtain a better insight into the ultrastructural composition of the cartilage repair tissue, biochemical MRI techniques have shown promising results in recent studies. [6][7][8] For the assessment of the constitution and organization of healthy articular cartilage as well as cartilage repair tissue, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and the mapping of transverse relaxation times (T2-mapping) are most often utilized. Whereas the dGEMRIC technique can visualize the glycosaminoglycan (GAG) component of articular cartilage, T2 mapping focuses on changes in water and collagen content and tissue anisotropy.…”

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Quantitative T2 mapping during follow‐up after matrix‐associated autologous chondrocyte transplantation (MACT): Full‐thickness and zonal evaluation to visualize the maturation of cartilage repair tissue

Welsch

Mamisch

Marlovits

et al. 2009

Journal Orthopaedic Research

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The purpose of this article was to evaluate the potential of in vivo zonal T2-mapping as a noninvasive tool in the longitudinal visualization of cartilage repair tissue maturation after matrix-associated autologous chondrocyte transplantation (MACT). Fifteen patients were treated with MACT and evaluated cross-sectionally, with a baseline MRI at a follow-up of 19.7 AE 12.1 months after cartilage transplantation surgery of the knee. In the same 15 patients, 12 months later (31.7 AE 12.0 months after surgery), a longitudinal 1-year followup MRI was obtained. MRI was performed on a 3 Tesla MR scanner; morphological evaluation was performed using a double-echo steadystate sequence; T2 maps were calculated from a multiecho, spin-echo sequence. Quantitative mean (full-thickness) and zonal (deep and superficial) T2 values were calculated in the cartilage repair area and in control cartilage sites. A statistical analysis of variance was performed. Full-tickness T2 values showed no significant difference between sites of healthy cartilage and cartilage repair tissue (p < 0.05). Using zonal T2 evaluation, healthy cartilage showed a significant increase from the deep to superficial cartilage layers (p < 0.05). Cartilage repair tissue after MACT showed no significant zonal increase from deep to superficial cartilage areas during baseline MRI (p > 0.05); however, during the 1-year follow-up, a significant zonal stratification could be observed (p < 0.05). Morphological evaluation showed no significant difference between the baseline and the 1-year follow-up MRI. T2 mapping seems to be more sensitive in revealing changes in the repair tissue compared to morphological MRI. In vivo zonal T2 assessment may be sensitive enough to characterize the maturation of cartilage repair tissue. ß

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“…Bu teknik, osteoartritlerde, kondrosit transplantasyonu sonrası kıkırdak yapısını değerlendirmede, tendon patolojileri sonrasında kıkırdak hasarının değerlen-dirilmesinde kullanılmıştır. [7] Araştırma aşamasında olan diğer yöntemler ise manyetizasyon transfer ve spektroskopidir. [8] Diğer ikincil bulgular, yağ yastıklarının adventisyal bursalarında sinoviyal proliferasyon ve ödem, medial ve lateral patellar retinakulum yapışma yüzlerin-de traksiyon ile ilişkili kistik değişiklikler şeklindedir (Şekil 4).…”

Section: Patellar Kondromalaziunclassified

The role of magnetic resonance imaging in the evaluation of patellofemoral joint diseases

Çobanoğlu¹

2012

TOTBİD Dergisi

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Delayed Gadolinium-enhanced MR to Determine Glycosaminoglycan Concentration in Reparative Cartilage after Autologous Chondrocyte Implantation: Preliminary Results

Abstract: Study results indicate that pre- and postcontrast imaging is necessary for delayed gadolinium-enhanced MR imaging evaluation of reparative cartilage after ACI.

Cited by 131 publications

References 32 publications

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

Quantitative T2 mapping during follow‐up after matrix‐associated autologous chondrocyte transplantation (MACT): Full‐thickness and zonal evaluation to visualize the maturation of cartilage repair tissue

The role of magnetic resonance imaging in the evaluation of patellofemoral joint diseases

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