Delayed hypersensitivity reactions to corticosteroids applied to mucous membranes

Bircher, A.J.; Pelloni, F.; Messmer, S. Langauer; Muller, D.

doi:10.1046/j.1365-2133.1996.d01-996.x

Cited by 17 publications

(20 citation statements)

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“…The most frequent reports of positive drug patch tests are related to the following drugs: betalactam antibiotics, especially amoxicillin (1,2,4,6,18,(24)(25)(26)(27)(28)(29)(30), cotrimoxazole (15), corticosteroids (1,31,32), heparin derivatives (1,(33)(34)(35)(36), pristinamycin (1,36), carbamazepine (1,2,20,(37)(38)(39)(40)(41)(42)(43)(44), diltiazem (1,45,46), diazepam (47), hydroxyzine (1,48), pseudoephedrine (1,21,22) and tetrazepam (1,16,(49)(50)(51).…”

Section: Commentmentioning

confidence: 99%

Guidelines for performing skin tests withdrugs in the investigation of cutaneous adverse drug reactions

et al. 2001

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Skin testing with a suspected drug has been reported to be helpful in determining the cause of cutaneous adverse drug reactions (CADR). Many isolated reports of positive drug skin tests are published, but without detailed information concerning the clinical features of the CADR and the method used in performing drug skin tests, such data are not very informative. A working party of the European Society of Contact Dermatitis (ESCD) for the study of skin testing in investigating cutaneous adverse drug reactions, has proposed the herein-reported guidelines for performing skin testing in CADR in order to standardize these procedures. In each reported case, the imputability of each drug taken at the onset of the CADR and a highly detailed description and characterization of the dermatitis need to be given. Drug skin tests are performed 6 weeks to 6 months after complete healing of the CADR. Drug patch tests are performed according to the methods used in patch testing in studying contact dermatitis. The commercialized form of the drug used by the patient is tested diluted at 30% pet. (pet.) and/or water (aq.). The pure drug is tested diluted at 10% in pet. or aq. In severe CADR, drug patch tests are performed at lower concentrations. It is also of value to test on the most affected site of the initial CADR. Drug prick tests are performed on the volar forearm skin with the commercialized form of the drug, but with sequential dilutions in cases of urticaria. Intradermal tests (IDT) are performed with sterile sequential dilutions (10-4, 10-3, 10-2, 10-1) of a pure sterile or an injectable form of the suspected drug with a small volume of 0.04 ml. Drug skin tests need to be read at 20 min and also later at D2 and D4 for patch tests, at D1 for prick tests and IDT. All these tests also need to be read at 1 week. The success of skin tests varies with the drug tested, with a high % of positive results, for example, with betalactam antibiotics, pristinamycin, carbamazepine and tetrazepam on patch testing, or with betalactam antibiotics and heparins on delayed readings of IDT. The results of drug skin tests also depend on the clinical features of the CADR. The use of appropriate control patients is necessary to avoid false-positive results.

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Section: Commentmentioning

confidence: 99%

Guidelines for performing skin tests withdrugs in the investigation of cutaneous adverse drug reactions

et al. 2001

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“…In our opinion, one should always proceed in this manner when anticipating a treatment for more than 10 days, especially when using high strength topical corticosteroids in aqueous solutions (3,8). Other local adverse effects are burning mouth, hypogeusia, oral hairy leukoplakia and hypersensitive reactions to the drug (3,12). -Systemic adverse effects In patients treated with high-potency TCs, there may e831 be adverse effects that show the systemic absorption of the drug with inhibition of the hypothalamic-pituitaryadrenal axis and secondary adrenal insufficiency.…”

Section: Adverse Effects Of Treatment With Tcs In Oral Pathologymentioning

confidence: 99%

The use of topical corticoids in oral pathology

González-Moles¹

2010

Med Oral

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This review examines the most important aspects of the use of topical corticosteroids in oral pathology. We provide a detailed analysis of the most common types of corticosteroids used, their methods of application and the clinical data that must be managed in order to monitor the effectiveness of the treatment. We also analyze the correctable causes of treatment failure and the possible adverse effects that may occur after applying these drugs. All of this is achieved by conducting a critical review of these concepts.

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“…Chronic eczematous eruption (35) Conjunctivitis (43) Increased diarrhoea Pruritus, dry or burning sensation (46,47) Eruption at some distance from the injection site, sometimes erythema multiforme (58) Lesions extending to previously unaffected areas of skin Steroidal rosacea, perinasal dermatitis, perioral dermatitis (35,36) Eczema or oedema of the eyelids, periorbital eruption…”

Section: In Vivo Testsmentioning

confidence: 99%

“…Nosebleeds (29) Contact allergy stomatitis (46,47,50) Generalized urticaria, angioedema (35,59) Erythroderma (61) Purpuric eruption (37) Inflammation of nasal fossae and/or sinus cavity (29) Dry cough (47) Anaphylactic shock (60) Baboon syndrome (62) Eczematous eruption at the periphery of the treated zone (Ôedge effectÕ) (34)(35)(36) Chronic rhinitis unrelieved or aggravated by topical CSs (29,46) Odynophagia/dysphagia (46,49) Oedema of the eyelids (63,64) Eruption of erythema multiforme (38)(39)(40) Perforation or ulceration of the nasal septum (48)…”

Section: Local Irritationmentioning

confidence: 99%

Allergic hypersensitivity to topical and systemic corticosteroids: a review

Baeck

Marot

Nicolas

et al. 2009

Allergy

101

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Corticosteroids, which are potent anti‐inflammatory and immunomodulator agents used in the treatment of various inflammatory diseases including allergic diseases, can in some cases produce immediate or delayed hypersensitivity reactions. This review summarizes the epidemiological and clinical characteristics of such reactions, including related diagnostic issues. It also presents a detailed analysis of the proposed immunological mechanisms including underlying cross‐reactions.

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Delayed hypersensitivity reactions to corticosteroids applied to mucous membranes

Cited by 17 publications

References 0 publications

Guidelines for performing skin tests withdrugs in the investigation of cutaneous adverse drug reactions

Guidelines for performing skin tests withdrugs in the investigation of cutaneous adverse drug reactions

The use of topical corticoids in oral pathology

Allergic hypersensitivity to topical and systemic corticosteroids: a review

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