Delayed macrophage targeting by clodronate liposomes worsens the progression of cytokine storm syndrome
Kunjan Khanna,
Emily Eul,
Hui Yan
et al.
Abstract:Excessive macrophage activation and production of pro-inflammatory cytokines are hallmarks of the Cytokine Storm Syndrome (CSS), a lethal condition triggered by sepsis, autoimmune disorders, and cancer immunotherapies. While depletion of macrophages at disease onset protects from lethality in an infection-induced CSS murine model, patients are rarely diagnosed early, hence the need to characterize macrophage populations during CSS progression and assess the therapeutic implications of macrophage targeting afte… Show more
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