2009
DOI: 10.1159/000209321
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Delayed Oxaliplatin-Induced Sensorimotor Polyneuropathy

Abstract: Background: To date, only a few cases have been reported that indicate that a delayed polyneuropathy may occur after chemotherapy with oxaliplatin. The clinical and electrophysiological manifestations of this delayed neurotoxicity have never been well documented. Case Reports: Nerve conduction studies were performed in 4 patients who developed acute peripheral neuropathy several months after completion of oxaliplatin-containing chemotherapy. Sensory nerve conduction was abnormal in all patients. In 2 patients,… Show more

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“…It is known that some anticancer drugs can cause peripheral neuropathy. Brouwers et al [ 13 ] described neuropathy occurring after treatment with a combination of oxaliplatin and cisplatin; Nardone et al [ 14 ] also reported 4 cases of acute peripheral neuropathy after completion of oxaliplatin treatment.…”
Section: Discussionmentioning
confidence: 99%
“…It is known that some anticancer drugs can cause peripheral neuropathy. Brouwers et al [ 13 ] described neuropathy occurring after treatment with a combination of oxaliplatin and cisplatin; Nardone et al [ 14 ] also reported 4 cases of acute peripheral neuropathy after completion of oxaliplatin treatment.…”
Section: Discussionmentioning
confidence: 99%
“…In all these four patients, nerve conduction studies were performed. Sensory nerve conduction was abnormal in all patients, while in 2 patients, the electrodiagnostic studies showed a mixed axonal and demyelinating sensorimotor polyneuropathy [ 12 ].…”
Section: Discussionmentioning
confidence: 99%