Delayed Recovery in Pediatric Sudden Sensorineural Hearing Loss Predicted via Magnetic Resonance Imaging

Wu, Xuan; Jiang, Hongyan; Wen, Lanying; Zong, Ling; Chen, Kaitian

doi:10.1177/0003489418769942

Cited by 4 publications

(2 citation statements)

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“…One was excluded due to inconsistencies within the article in the number of patients with hearing recovery 5 . The other was excluded because of overlap in the patient population and data presented in this article 25 and those presented in a more comprehensive included article 7 . Consequently, 13 studies were included in final qualitative and quantitative analyses.…”

Section: Resultsmentioning

confidence: 99%

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Sudden Sensorineural Hearing Loss in Children—Management and Outcomes: A Meta‐analysis

2020

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Objective To identify which patient characteristics and treatments are associated with hearing improvement in patients with pediatric sudden sensorineural hearing loss (SSNHL). Methods PubMed, Web of Science, Cochrane Library, PsycINFO, and Cumulative Index to Nursing and Allied Health Literature were systematically searched for articles published before February 5, 2019, and references of relevant articles were screened. Original English‐language case series and cohort studies were included if they addressed SSNHL in patients <20 years of age. Study characteristics, patient demographics, symptoms, treatments, and hearing outcomes were extracted. The primary outcome was hearing improvement. Results Thirteen studies were included, totaling 605 patients (670 ears). Hearing did not improve in 46.7% of ears (95% confidence interval [CI]: 34.4% to 59.0%). Imaging (computed tomography and/or magnetic resonance imaging) results were described in three studies, and 24.2% of ears (95% CI: 7.7% to 40.6%) had abnormal findings. The most common serological finding was cytomegalovirus immunoglobulin (Ig)G or IgM (34.3% of ears tested, 95% CI: −2.9% to 71.6%). Unilateral hearing loss (odds ratio [OR]:3.85, P < .001), tinnitus (OR: 2.20, P = .003), age >12 years (OR: 2.11, P = .002), and ascending audiogram (OR: 3.66, P = .005), but not systemic or intratympanic steroids, were associated with increased odds of partial or complete improvement. In contrast, profound hearing loss (OR: 0.29, P < .001) and treatment delay of >6 days (OR: 0.27, P < .001) were associated with decreased odds of improvement. Conclusions Despite treatment, half of patients had no improvement in hearing. Prognostic factors associated with hearing improvement were generally consistent with those established in the adult population. Further research with consistent definitions for hearing improvement is needed to improve the understanding and treatment of pediatric SSNHL. Level of Evidence Laryngoscope, 131:425–434, 2021

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Section: Resultsmentioning

confidence: 99%

“…5 This made it unreliable to extract the appropriate numbers to insert into our meta-analysis. One other study 25 was excluded because it reported outcomes for a subset of patients that were reported more comprehensively in another included study. 7 Therefore, 13 studies were identified as appropriate for inclusion.…”

Section: Study Characteristicsmentioning

confidence: 99%