Delayed skin test reactivity to Propionibacterium acnes correlates with severity of inflammation in acne vulgaris

Kersey, Peter; Sussman, M.; Dahl, M.G.C.

doi:10.1111/j.1365-2133.1980.tb01687.x

Cited by 50 publications

(25 citation statements)

References 17 publications

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“…Puhvel et al [22]showed that lymphocyte stimulation by P. acnes is significantly increased in patients with nodulocystic acne. Kersey et al [23]demonstrated that delayed skin test reactivity to P. acnes correlates with the severity of the disease. Recent studies performed by Jappe et al [24]revealed that P. acnes could activate both peripheral blood mononuclear cells of adults and cord blood mononuclear cells and that the reactions produced are both antigenic and T cell mitogenic.…”

Section: Abnormalities Of the Microbial Floramentioning

confidence: 99%

The Role of Innate Immunity in the Pathogenesis of Acne

et al. 2003

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Acne is a multifactorial disease of the pilosebaceous follicle. The most significant pathogenetic factors of acne are: abnormal ductal keratinization, increased sebum secretion, abnormalities of the microbial flora and inflammation. The pilosebaceous unit is an immunocompetent organ. Keratinocytes and sebocytes may act as immune cells capable of pathogen recognition and abnormal lipid presentation, and they might have an important role in initiating and perpetuating the activation of both innate and adaptive immune responses. The elements of the skin immune system are involved in the development of both noninflammatory and inflammatory acne lesions.

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Section: Abnormalities Of the Microbial Floramentioning

confidence: 99%

The Role of Innate Immunity in the Pathogenesis of Acne

et al. 2003

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“…A delayed type hypersensitivity was also suggested by Kersey et al [296] who performed skin testing by using heat-killed P. acnes in acne patients. The intensity of the response was correlated with the severity of acne [296]. For Norris and Cunliffe [297] the infiltrates were mainly lymphoid in the 6- and 24-hour biopsies of inflammatory lesions.…”

Section: Inflammation: Evolving Actor In Acne Pathogenesismentioning

confidence: 67%

“…Intradermal injection of P. acnes provokes an inflammatory reaction suggestive of cell-mediated delayed allergy [250]. A delayed type hypersensitivity was also suggested by Kersey et al [296] who performed skin testing by using heat-killed P. acnes in acne patients. The intensity of the response was correlated with the severity of acne [296].…”

Section: Inflammation: Evolving Actor In Acne Pathogenesismentioning

confidence: 97%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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“…The delayed-type hypersensitivity reaction in acne appears to be mounted against one or more propionibacterial antigenic components (13,16,38). While it is not a life-threatening condition, acne can have serious psychological and socioeconomic consequences that severely affect a patient's quality of life (7,14,15,18).…”

mentioning

confidence: 99%

Antipropionibacterial Activity of BAL19403, a Novel Macrolide Antibiotic

Heller

Kellenberger

Shapiro

2007

Antimicrob Agents Chemother

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BAL19403 exemplifies a new family of macrolide antibiotics with excellent in vitro activity against propionibacteria. MICs indicated that BAL19403 was very active against erythromycin-resistant and clindamycinresistant propionibacteria with mutations in the region from positions 2057 to 2059 (Escherichia coli numbering) of the 23S rRNA, although it is less active against those rare clinical isolates in which a methyltransferase, ErmX, confers macrolide and lincosamide resistance by dimethylation of the adenine moiety at position 2058. BAL19403 was predominantly bacteriostatic toward the propionibacteria, and population analyses indicated resistance selection frequencies for BAL19403 and the comparator drugs (erythromycin, clindamycin) in the range 10 ؊8 to 10 ؊9 for cutaneous propionibacteria with diverse antibiotic resistance profiles. On the basis of its antipropionibacterial activity and its high anti-inflammatory activity, BAL19403 represents a promising topical treatment for mild to moderate inflammatory acne vulgaris.

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Delayed skin test reactivity to Propionibacterium acnes correlates with severity of inflammation in acne vulgaris

Cited by 50 publications

References 17 publications

The Role of Innate Immunity in the Pathogenesis of Acne

The Role of Innate Immunity in the Pathogenesis of Acne

Acne Pathogenesis: History of Concepts

Antipropionibacterial Activity of BAL19403, a Novel Macrolide Antibiotic

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