Delayed Time to Peak Strain Identifies Mitral Valve Prolapse Patients at Higher Arrhythmic Risk

Ermakov, Simon; Gulhar, Radhika; Lim, Lisa; Bibby, Dwight; Tseng, Zian H.; Abraham, Theodore P.; Nah, Gregory; Delling, Francesca N.

doi:10.1016/s0735-1097(18)32092-8

Cited by 2 publications

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“…Several echocardiographic features of the mitral valve apparatus and myocardium, such as leaflet thickness ≥5 mm in diastole, mitral annulus disjunction (MAD), paradoxical systolic increase of the mitral annulus diameter, systolic curling, and basal lateral hypertrophy (Figure 3 and eFigure in the Supplement), have been associated with ventricular arrhythmias (Table). In addition, functional abnormalities, including greater tissue Doppler velocity of the mitral annulus (Pickelhaube sign), increased regional postsystolic index, time-to-peak strain, and mechanical dispersion were previously shown to be associated with ventricular arrhythmias and risk for SCD in patients with MVP.…”

Section: Morphofunctional Characteristics Of the Mitral Valvementioning

confidence: 99%

Association Between Malignant Mitral Valve Prolapse and Sudden Cardiac Death

et al. 2020

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IMPORTANCE Malignant arrhythmic mitral valve prolapse (MVP) phenotype poses a substantial risk of sudden cardiac death (SCD), and an estimated 26 000 individuals in the United States are at risk of SCD per year. Thus, identifying risk-stratification strategies for SCD is imperative.OBSERVATIONS Patients with MVP have a heterogenous clinical spectrum, ranging from a benign course to a devastating complication such as SCD. Some of the high-risk markers of MVP, which are identified electrocardiographically, include inverted or biphasic T waves, QT dispersion, QT prolongation, and premature ventricular contractions originating from the left ventricular outflow tract and papillary muscles. Morphofunctional characteristics of SCD are leaflet thickness of 5 mm or greater, mitral annulus disjunction, paradoxical systolic increase of the mitral annulus diameter, increased tissue Doppler velocity of the mitral annulus, and higher mechanical dispersion on echocardiography and fibrosis identified by late gadolinium enhancement on cardiac magnetic resonance imaging.CONCLUSIONS AND RELEVANCE Findings from this review suggest that SCD can occur earlier in the course of MVP from complex arrhythmias that are triggered by the repeated tugging and traction of the chordopapillary muscle unit and basal mid-myocardium, even before macrofibrosis can be identified in these regions by late gadolinium enhancement on cardiac magnetic resonance imaging. Some of the newer markers identified by speckle-tracking Doppler, such as mechanical dispersion, myocardial work index, and postsystolic shortening, need further validation in a larger population.

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Section: Morphofunctional Characteristics Of the Mitral Valvementioning

confidence: 99%

Association Between Malignant Mitral Valve Prolapse and Sudden Cardiac Death

et al. 2020

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“…Pacientes con patrones de mayor velocidad pueden tener más riesgo de desarrollar arritmias ventriculares (6) . • Strain global longitudinal (SGL): es característica la presencia de un aumento a niveles "supranormales" (>24%) de los valores de SGL de forma heterogénea, siendo mayor en la regiones postero-lateral basal y media de la pared ventricular adyacente al músculo papilar (7) . Realmente se trata de otro parámetro más que refleja la hipercontractilidad de dicha región secundaria a la tracción de la válvula hiperlaxa sobre el miocardio.…”

Section: Características Morfológicas Y Funcionales En El Pvmunclassified

“…2022 (Diciembre); 5 (3): 11-15 y pueden explicarse por un tiempo más largo hasta la contracción máxima de los segmentos posterolaterales medios basales que están sujetos a la tracción del músculo papilar y el miocardio adyacente por el prolapso de las valvas en la sístole media o tardía. Su distribución segmentaria es igualmente heterogénea y se postula que el aumento de estos parámetros se correlacionaría a su vez con mayor demanda metabólica y explicaría la evolución hacia la fibrosis local (7,9) .…”

Section: Características Morfológicas Y Funcionales En El Pvmunclassified

Prolapso mitral maligno: signos predictores

Regidor

Ortiz

Diego

2022

Rev Ecocar Pract (RETIC)

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El prolapso de la válvula mitral (PVM) es una valvulopatía de alta prevalencia en la población general. Es una entidad habitualmente considerada benigna, pero en un subgrupo de pacientes asocia una evolución clínica desfavorable, incluyendo desde la insuficiencia valvular severa hasta la muerte súbita de causa arrítmica. En este artículo se revisan métodos para una evaluación morfofuncional completa con ecocardiografía y resonancia magnética cardiaca, incluyendo algunos parámetros que recientemente se han identificado como predictores del desarrollo de miocardiopatía y un peor pronóstico.

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Delayed Time to Peak Strain Identifies Mitral Valve Prolapse Patients at Higher Arrhythmic Risk

Cited by 2 publications

References 0 publications

Association Between Malignant Mitral Valve Prolapse and Sudden Cardiac Death

Association Between Malignant Mitral Valve Prolapse and Sudden Cardiac Death

Prolapso mitral maligno: signos predictores

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