Deletion of vanilloid receptor 1_expressing primary afferent neurons for pain control

Karai, Laszlo; Brown, Dorothy Cimino; Mannes, Andrew J.; Connelly, Stephen; Brown, Jacob D.; Gandal, Michael J.; Wellisch, Ofer M.; Neubert, John K.; Oláh, Zoltán; Iadarola, Michael J.

doi:10.1172/jci20449

Cited by 307 publications

(252 citation statements)

References 58 publications

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“…Consistent with these considerations, luminal application of capsaicin or capsaicin injection into the gut wall lowers sensory threshold or triggers pain in humans (Drewes et al, 2003;Schmulson et al, 2003;Lee et al, 2004). Interestingly, prolonged administration of red pepper, which contains capsaicin, improved symptoms in patients with functional dyspepsia (Bortolotti et al, 2002), likely because of neurotoxic effects of persistent TRPV1 stimulation that leads to transient analgesia in experimental models of neuropathic or inflammatory pain (Karai et al, 2004).…”

Section: Discussionmentioning

confidence: 89%

TRPV1 Function in Mouse Colon Sensory Neurons Is Enhanced by Metabotropic 5-Hydroxytryptamine Receptor Activation

Sugiuar

Bielefeldt²,

Gebhart³

2004

J. Neurosci.

125

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Using whole-cell patch-clamp methods, we examined the hypothesis that serotonin [5-hydroxytryptamine (5-HT)] receptor activation enhances TRPV1 function in mouse colon sensory neurons in lumbosacral dorsal root ganglia, which were identified by retrograde labeling with DiI (1,1Ј-dioctadecyl-3,3,3Ј,3-tetramethlindocarbocyanine methanesulfonate) injected into multiple sites in the wall of the descending colon. 5-HT increased membrane excitability at a temperature below body temperature in response to thermal ramp stimuli in colon sensory neurons from wild-type mice, but not from TRPV1 knock-out mice. 5-HT significantly enhanced capsaicin-, heat-, and proton-evoked currents with an EC 50 value of 2.2 M. 5-HT (1 M) significantly increased capsaicin-evoked (100 nM) and proton-evoked (pH 5.5) currents 1.6-and 4.7-fold, respectively, and significantly decreased the threshold temperature for heat current activation from 42 to 38°C.

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Section: Discussionmentioning

confidence: 89%

TRPV1 Function in Mouse Colon Sensory Neurons Is Enhanced by Metabotropic 5-Hydroxytryptamine Receptor Activation

Sugiuar

Bielefeldt²,

Gebhart³

2004

J. Neurosci.

125

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show abstract

“…Except for some aspects of heat perception, all other sensory modalities (proprioception, touch, and vibration) were preserved and functional abilities improved. There were no adverse behavioral changes [2].…”

Section: Reducing Cancer Painmentioning

confidence: 87%

News from NIH: pain management

Henderson

Thomas

Cantor

et al. 2012

Behav. Med. Pract. Policy Res.

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“…For instance, TRPV1 null mice show virtually no thermal hyperalgesia during inflammation (7). Furthermore, rapid desensitization of TRPV1-expressing fibers by administration of the potent agonist resiniferatoxin attenuates experimental inflammatory hyperalgesia and neurogenic inflammation as well as naturally occurring cancer pain and debilitating arthritic pain (8).…”

Section: The Trpv1mentioning

confidence: 99%

Targeting the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Assembly Domain Attenuates Inflammation-induced Hypersensitivity

Flynn

Chapman

Iftinca

et al. 2014

Journal of Biological Chemistry

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Background: Assembly of TRPV1 subunits forms functional channels that transduce noxious stimuli. Results: We identified a region of the TRPV1 C terminus that mediates subunit assembly and used a disrupting peptide to block association. Conclusion: A short C-terminal motif enables subunit association. Disrupting assembly of TRPV1 subunits attenuates inflammatory hyperalgesia. Significance: TRPV1 subunit association could be targeted for pain relief.

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Deletion of vanilloid receptor 1_expressing primary afferent neurons for pain control

Cited by 307 publications

References 58 publications

TRPV1 Function in Mouse Colon Sensory Neurons Is Enhanced by Metabotropic 5-Hydroxytryptamine Receptor Activation

TRPV1 Function in Mouse Colon Sensory Neurons Is Enhanced by Metabotropic 5-Hydroxytryptamine Receptor Activation

News from NIH: pain management

Targeting the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Assembly Domain Attenuates Inflammation-induced Hypersensitivity

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