Delivering DNA from photocrosslinked, surface eroding polyanhydrides

Quick, Deborah J.; Macdonald, Kelly K.; Anseth, Kristi S.

doi:10.1016/j.jconrel.2004.03.001

Cited by 84 publications

(51 citation statements)

References 39 publications

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“…Delivery of DNA molecules for gene therapy is a challenge and nonviral carriers are always under search. Photocrosslinked polyanhydrides could allow repeated transfection, with an appropriate amount of DNA for the rate of local cell division and the cells capacity for DNA uptake [170,171] . Bioadhesive nanoparticles of polyanhydrides were also found to have potential for oral delivery of DNA [172] .…”

Section: Biomedical Applications 69mentioning

confidence: 99%

Polyanhydrides

Domb¹,

Jain²,

Kumar³

2011

Handbook of Biodegradable Polymers

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Section: Biomedical Applications 69mentioning

confidence: 99%

Polyanhydrides

Domb¹,

Jain²,

Kumar³

2011

Handbook of Biodegradable Polymers

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“…Previous research has demonstrated numerous advantages of using photopolymers for both bone and soft-tissue regeneration, as well as for the sustained delivery of growth factors, encapsulated proteins, and plasmid DNA. [3,5,[13][14][15][16][17][18][19][20][21][22][23][24] One of the key advantages displayed by these photopolymeric materials is their ability to form highly crosslinked networks rapidly under physiological conditions while providing spatial and temporal reaction control. Additionally, many of the material properties and the degradation rate are strongly influenced by network structure.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of degradable thiol-allyl ether photopolymers

Rydholm

Reddy

Anseth

et al. 2007

Polymer

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Degradable thiol-ene photopolymer networks were formed through radically mediated step growth reactions. Variations in the network structure were used to alter the initial and temporal moduli, mass loss profiles, and equilibrium swelling ratios. Mass loss rates varied with changes in the solvent concentration, monomer molecular weight, average monomer functionality, and concentration of degradable linkages. The time required for the networks to degrade completely ranged from 1.20 ± 0.01 to 24.5 ± 0.1 days, which corresponded to hydrolysis rates of 0.18 ± 0.01 and 0.021 ± 0.0003 days -1 . Initial moduli also varied considerably as a function of network structure, ranging from 150 ± 35 to nearly 5000 ± 100 kPa, and initial equilibrium swelling ratios ranged from 2.5 ± 0.01 to 18.7 ± 2. Collectively, these results demonstrate how the material properties and the mass loss behavior of thiol-ene networks can be independently tuned for specific applications.

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“…The deuterated solvent used to dissolve the samples (5-10 mg) was DMSOd 6 , with the solvent as the internal reference. Infrared (IR) spectra were measured on a Thermo Nicolet/Avatar 360 FT-IR spectrometer, by depositing samples onto NaCl plates (if liquid) or solvent-casting samples from methylene chloride onto NaCl plates (if solid).…”

Section: Methodsmentioning

confidence: 99%

Synthesis and characterization of antiseptic-based poly(anhydride-esters)

Schmeltzer

Uhrich

2006

Polym. Bull.

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Poly(anhydride-esters) were prepared from catechol, fenticlor and hexachlorophene. The molecular weights (M w ) of the polymers were typically > 10,000 Da with glass transition temperatures (T g ) ranging from 23 to 84 °C. The thermal characteristics of the polymers paralleled the melting temperatures of the chemically incorporated antiseptic molecules. The in vitro release of the chemically incorporated antiseptic molecules were monitored over a 12 week period. For comparison, the in vitro release of physically admixed antiseptic molecules were also observed.After 12 weeks, the polymers were not completely degraded with drug release ranging from less than 1 to 55 %. Sessile-drop contact angles indicated that the polymers were relatively hydrophobic, contributing to the slow polymer degradation rates.

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Delivering DNA from photocrosslinked, surface eroding polyanhydrides

Cited by 84 publications

References 39 publications

Polyanhydrides

Polyanhydrides

Development and characterization of degradable thiol-allyl ether photopolymers

Synthesis and characterization of antiseptic-based poly(anhydride-esters)

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