Delivering more for less: nanosized, minimal-carrier and pharmacoactive drug delivery systems

Etter, Emma L.; Mei, Kuo‐Ching; Nguyen, Juliane

doi:10.1016/j.addr.2021.113994

Cited by 59 publications

(29 citation statements)

References 86 publications

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“…Nanotechnology is finding increasing applications in medicine; in particular nanoparticles (NPs) can be used as vehicles to transport and deliver different classes of biologically active molecules (so-called nanocarriers), including chemotherapeutics, antibiotics, anti-inflammatory drugs, hormones, fluorophores, targeting agents [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ], depending on the pathology considered, acting both in diagnosis and therapy. Their main advantage is linked to their nanoscale dimensions, enabling them to carry high amounts of molecules to chosen body sites, in the meantime protecting the drugs from rapid degradation or clearance.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

et al. 2022

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Luminescent nanoparticles are innovative tools for medicine, allowing the imaging of cells and tissues, and, at the same time, carrying and releasing different types of molecules. We explored and compared the loading/release ability of diclofenac (COX-2 antagonist), in both undoped- and luminescent Terbium3+ (Tb3+)-doped citrate-coated carbonated apatite nanoparticles at different temperatures (25, 37, 40 °C) and pHs (7.4, 5.2). The cytocompatibility was evaluated on two osteosarcoma cell lines and primary human osteoblasts. Biological effects of diclofenac-loaded-nanoparticles were monitored in an in vitro osteoblast’s cytokine–induced inflammation model by evaluating COX-2 mRNA expression and production of PGE2. Adsorption isotherms fitted the multilayer Langmuir-Freundlich model. The maximum adsorbed amounts at 37 °C were higher than at 25 °C, and particularly when using the Tb3+ -doped particles. Diclofenac-release efficiencies were higher at pH 5.2, a condition simulating a local inflammation. The luminescence properties of diclofenac-loaded Tb3+ -doped particles were affected by pH, being the relative luminescence intensity higher at pH 5.2 and the luminescence lifetime higher at pH 7.4, but not influenced either by the temperature or by the diclofenac-loaded amount. Both undoped and Tb3+-doped nanoparticles were cytocompatible. In addition, diclofenac release increased COX-2 expression and decreased PGE2 production in an in vitro inflammation model. These findings evidence the potential of these nanoparticles for osteo-localized delivery of anti-inflammatory drugs and the possibility to localize the inflammation, characterized by a decrease in pH, by changes in luminescence.

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Section: Introductionmentioning

confidence: 99%

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

et al. 2022

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“…By introducing the target molecules in these delivery systems, oxidative modulators will play a role in specific sites such as tumor sites or cells. An ideal delivery system should be characterized by a high loading, easy targeting, biodegradability, and high biocompatibility [58]. Here, we described the most representative delivery systems for oxidative modulators, including liposomes, polymer delivery systems, inorganic particles, and other types of delivery systems.…”

Section: Delivery Systems For Oxidative Modulatorsmentioning

confidence: 99%

Advances in Delivering Oxidative Modulators for Disease Therapy

Wei

Yue

et al. 2022

Research

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Oxidation modulators regarding antioxidants and reactive oxygen species (ROS) inducers have been used for the treatment of many diseases. However, a systematic review that refers to delivery system for divergent modulation of oxidative level within the biomedical scope is lacking. To provide a comprehensive summarization and analysis, we review pilot designs for delivering the oxidative modulators and the main applications for inflammatory treatment and tumor therapy. On the one hand, the antioxidants based delivery system can be employed to downregulate ROS levels at inflammatory sites to treat inflammatory diseases (e.g., skin repair, bone-related diseases, organ dysfunction, and neurodegenerative diseases). On the other hand, the ROS inducers based delivery system can be employed to upregulate ROS levels at the tumor site to kill tumor cells (e.g., disrupt the endogenous oxidative balance and induce lethal levels of ROS). Besides the current designs of delivery systems for oxidative modulators and the main application cases, prospects for future research are also provided to identify intelligent strategies and inspire new concepts for delivering oxidative modulators.

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“…Cancer is a deadly disease with more than 10 million new cases each year 1 due to low specificity, poor solubility, poor bioavailability, multi-drug resistance, low therapeutic results, and high cytotoxicity of conventional chemotherapeutic medication. 2 Prostate, lungs, 3 stomach, 4 and colorectal cancer 5 are different and the most common types of cancer. Indeed, careful investigation of biologically related features of living systems has always been an important subject of several works to provide insightful information in such cases of immunotherapy, 6,7 chemotherapy, 8,9 radiotherapy, 10 and surgery.…”

Section: Introductionmentioning

confidence: 99%

Controlled supramolecular interaction to enhance the bioavailability of hesperetin to targeted cancer cells through graphyne: a comprehensive in silico study

et al. 2022

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Delivering more for less: nanosized, minimal-carrier and pharmacoactive drug delivery systems

Cited by 59 publications

References 86 publications

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

Biomimetic Citrate-Coated Luminescent Apatite Nanoplatforms for Diclofenac Delivery in Inflammatory Environments

Advances in Delivering Oxidative Modulators for Disease Therapy

Controlled supramolecular interaction to enhance the bioavailability of hesperetin to targeted cancer cells through graphyne: a comprehensive in silico study

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