2020
DOI: 10.1016/j.niox.2019.11.003
|View full text |Cite
|
Sign up to set email alerts
|

Delivering nitric oxide into human skin from encapsulated S-nitrosoglutathione under UV light: An in vitro and ex vivo study

Abstract: Nitric oxide (NO) is a crucial molecule in the human body. The encapsulation of exogenous NO donors into chitosan nanoparticles (CS NPs) has been widely used to overcome NO drawbacks in pharmacological applications, such as, its short half-life. The NO donor, S-nitrosoglutathione (GSNO), was encapsulated into CS NPs (GSNO-CS NPs) and characterized by AFM and DLS measurements. The nanoparticles presented a hydrodynamic size of 123.3 ± 1.5 nm and a polydispersity of 0.25 ± 0.01. The ability of GSNO-CS NPs, combi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
7
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 15 publications
(7 citation statements)
references
References 49 publications
0
7
0
Order By: Relevance
“…(Williams 1999;Noble and Williams 2000;Zhelyaskov et al 1998;de Souza et al 2019). Light can be used to promote the photo-release of NO from RSNOs (Sexton et al 1994;Zhelyaskov et al 1998;de Souza et al 2019;Pelegrino et al 2020). Pelegrino et al 2020 irradiated a solution of GSNO at 1.0 mmol L −1 and showed a peak of NO production at 310 nm.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…(Williams 1999;Noble and Williams 2000;Zhelyaskov et al 1998;de Souza et al 2019). Light can be used to promote the photo-release of NO from RSNOs (Sexton et al 1994;Zhelyaskov et al 1998;de Souza et al 2019;Pelegrino et al 2020). Pelegrino et al 2020 irradiated a solution of GSNO at 1.0 mmol L −1 and showed a peak of NO production at 310 nm.…”
Section: Introductionmentioning
confidence: 99%
“…Light can be used to promote the photo-release of NO from RSNOs (Sexton et al 1994;Zhelyaskov et al 1998;de Souza et al 2019;Pelegrino et al 2020). Pelegrino et al 2020 irradiated a solution of GSNO at 1.0 mmol L −1 and showed a peak of NO production at 310 nm. Lopes-Oliveira et al 2019 evaluated S-nitroso-mercaptosuccinic acid (S-nitroso-MSA, at initial concentration of 2 mmol L −1 ) decomposition with NO release irradiated with white light.…”
Section: Introductionmentioning
confidence: 99%
“…The results showed that the combined treatment significantly increased the NO and S-nitrosothiol levels in human skin samples. This effect can reproduce the cardiovascular benefits without negative side effects of skin exposure to UV light [132]. In the same way, a recent study has described the development of an in-situ forming Fmoc-dipheylalanine hydrogel releasing s-nitroson-acetylpenicillamine (FmocFF-SNAP) for mice renal (I/R) injury.…”
Section: Exogenous Nitric Oxide In Regenerative Medicinementioning
confidence: 93%
“…Chitosan nanoparticles (CS NPs) are reported to increase GSNO stability and absorption of NO through skin [ 59 , 60 ]. GSH loaded chitosan NPs are prepared by ionotropic gelation process, followed by nitrozation of GSH-CS NPs leading to the formation of GSNO-CS NPs.…”
Section: S -Nitrozation Of Gsh Loaded Nano/micro-formulationmentioning
confidence: 99%