Dem MS-Phänotyp auf der Spur

Ziemssen, Tjalf

doi:10.1007/s15202-019-2277-6

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…Due to this heterogeneity and the intra-individual unpredictable and inter-individually quite variable course, the diagnosis, phenotyping and monitoring of MS is very challenging ( 18 , 19 ). The multidimensional disease characteristics of each patient should be made quantifiable to allow phenotyping of the individual disease characteristics and long-term monitoring of these parameters ( 20 ). This leads to a large amount of multidimensional data.…”

Section: Multiple Sclerosis Requires Precision Medicinementioning

confidence: 99%

“…Starting from neurological-clinical parameters, they range from quantitative assessment of individual neurological functional systems (e.g. cognition, gait analysis), through imaging (MRI, ocular coherence tomography (OCT)), electrophysiological methods and the inclusion of patient-reported outcomes (PRO), up to new molecular and digital biomarkers ( 20 ). This data can be obtained in the setting of clinical trials or in real world practice, which represents also differences in its collection, volume, veracity and availability.…”

Section: Multiple Sclerosis Requires Precision Medicinementioning

confidence: 99%

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Digital Twins for Multiple Sclerosis

et al. 2021

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An individualized innovative disease management is of great importance for people with multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional disease. However, an individual state of the art strategy, with precise adjustment to the patient’s characteristics, is still far from being part of the everyday care of pwMS. The development of digital twins could decisively advance the necessary implementation of an individualized innovative management of MS. Through artificial intelligence-based analysis of several disease parameters – including clinical and para-clinical outcomes, multi-omics, biomarkers, patient-related data, information about the patient’s life circumstances and plans, and medical procedures – a digital twin paired to the patient’s characteristic can be created, enabling healthcare professionals to handle large amounts of patient data. This can contribute to a more personalized and effective care by integrating data from multiple sources in a standardized manner, implementing individualized clinical pathways, supporting physician-patient communication and facilitating a shared decision-making. With a clear display of pre-analyzed patient data on a dashboard, patient participation and individualized clinical decisions as well as the prediction of disease progression and treatment simulation could become possible. In this review, we focus on the advantages, challenges and practical aspects of digital twins in the management of MS. We discuss the use of digital twins for MS as a revolutionary tool to improve diagnosis, monitoring and therapy refining patients’ well-being, saving economic costs, and enabling prevention of disease progression. Digital twins will help make precision medicine and patient-centered care a reality in everyday life.

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Section: Multiple Sclerosis Requires Precision Medicinementioning

confidence: 99%

Section: Multiple Sclerosis Requires Precision Medicinementioning

confidence: 99%

Digital Twins for Multiple Sclerosis

et al. 2021

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“…Triangles show the relative longitudinal alterations of the values with the last visits -red triangles indicate a worsening and green triangles an improvement compared to the last routine check; In the right column the absolute values of the current gait analysis evaluation are illustrated, the traffic light system represents the patient's performance according to the reference values; EC, Eyes closed; MSWS-12, 12-point gait scale Multiple Sclerosis; EDSS, Extended Disability Status Scale; FAP-Score, Score of the functional ambulation profile. (Ziemssen, 2019). Therefore, a straightforward but also detailed quantitative analysis of gait is an important part of the individual monitoring.…”

Section: Resultsmentioning

confidence: 99%

The Dresden Protocol for Multidimensional Walking Assessment (DMWA) in Clinical Practice

et al. 2020

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Walking impairments represent one of the most debilitating symptom areas for people with multiple sclerosis (MS). It is important to detect even slightest walking impairments in order to start and optimize necessary interventions in time to counteract further progression of the disability. For this reason, a regular monitoring through gait analysis is highly necessary. At advanced stages of MS with significant walking impairment, this assessment is also necessary to optimize symptomatic treatment, choose the most suitable walking aid and plan individualized rehabilitation. In clinical practice, walking impairment is only assessed at higher levels of the disease using e.g., the Expanded Disability Status Scale (EDSS). In contrast to the EDSS, standardized functional tests such as walking speed, walking endurance and balance as well as walking quality and gait-related patient-reported outcomes allow a more holistic and sensitive assessment of walking impairment. In recent years, the MS Center Dresden has established a standardized monitoring procedure for the routine multidimensional assessment of gait and balance disorders. In the following protocol, we present the techniques and procedures for the analysis of gait and balance of people with MS at the MS Center Dresden. Patients are assessed with a multidimensional gait analysis at least once a year. This enables long-term monitoring of walking impairment, which allows early active intervention regarding further progression of disease and improves the current standard clinical practice.

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Dem MS-Phänotyp auf der Spur

Cited by 2 publications

References 24 publications

Digital Twins for Multiple Sclerosis

Digital Twins for Multiple Sclerosis

The Dresden Protocol for Multidimensional Walking Assessment (DMWA) in Clinical Practice

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