2017
DOI: 10.1177/1010428317706216
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Demethoxycurcumin in combination with ultraviolet radiation B induces apoptosis through the mitochondrial pathway and caspase activation in A431 and HaCaT cells

Abstract: Photodynamic therapy is widely used in the clinical treatment of tumors, especially skin cancers. It has been reported that the photosensitizer curcumin, in combination with ultraviolet radiation B, induces HaCaT cell apoptosis, and this effect may be due to the activation of caspase pathways. In this study, we examined the photodynamic effects of demethoxycurcumin, a more stable analogue of curcumin, to determine whether it could induce apoptosis in skin cancer cells. We investigated the effects of a combinat… Show more

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Cited by 25 publications
(13 citation statements)
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“…Furthermore, astilbin was found to enhance the expression levels of cleaved caspase-3, -8 and -9 in MDA-MB-231 and MCF-7 cells, which is consistent with the earlier finding that mitochondrial function contributes to the activation of caspase (34). Caspase-8, mainly located in the mitochondria, can cleave itself to adopt the fully activated form, which results in the activation of Bid protein, leading to the dissipation of MMP (35)(36)(37).…”
Section: Discussionsupporting
confidence: 90%
“…Furthermore, astilbin was found to enhance the expression levels of cleaved caspase-3, -8 and -9 in MDA-MB-231 and MCF-7 cells, which is consistent with the earlier finding that mitochondrial function contributes to the activation of caspase (34). Caspase-8, mainly located in the mitochondria, can cleave itself to adopt the fully activated form, which results in the activation of Bid protein, leading to the dissipation of MMP (35)(36)(37).…”
Section: Discussionsupporting
confidence: 90%
“…AU also inhibited ROS production and prevented dissipation of the mitochondrial membrane potential (MMP). Bcl-2 and Bax, which are located in the mitochondrial membrane, inhibit the production of oxygen free radicals and act as antioxidants to protect against mitochondrial apoptosis [28,29]. Under conditions of oxidative stress, the rate of apoptosis among mature bone cells increases and can contribute to osteoporosis [30].…”
Section: Discussionmentioning
confidence: 99%
“…The association between demethoxycurcumin as a photosensitizer and ultraviolet B radiation induced apoptosis in vitro in A431 and HaCaT cells, by activating p53 and caspase pathways, increasing Bax and p-p65 expression and suppressing Bcl-2, Mcl-1 and NF-κB pathway. At the same time, high levels of reactive oxygen species were observed, along with the significant depolarization of the mitochondrial membrane [145].…”
Section: Skin Cancermentioning
confidence: 96%