Demethylbellidifolin preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level

Jiang, De-Jian; Jiang, Jun-Lin; Zhu, Honglin; Tan, Gui‐Shan; Liu, Shaoqian; Xu, Kang‐Ping; Li, Yuan‐Jian

doi:10.1016/j.jep.2004.03.055

Cited by 23 publications

(10 citation statements)

References 38 publications

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“…Our results in cultured endothelial cells treated with LDL, ox-LDL or LPC also showed that xanthones significantly decreased the level of ADMA concomitantly with an improvement in DDAH activity (36)(37)(38)(39). As mentioned above, xanthones can significantly attenuate the levels of lipid peroxides and of TNF-á induced by ox-LDL (36)(37)(38)(39). These findings suggest that xanthones-induced decreased level of ADMA is related to an increase of DDAH activity due to inhibition of oxidative stress via antioxidant and/or antiinflammatory activities.…”

Section: Mechanism Of the Inhibitory Effect Of Xanthones On Adma Levelsmentioning

confidence: 66%

“…Some antioxidants have been shown to attenuate homocysteine-or high glucose-induced ADMA accumulation by reversing the decrease in DDAH activity (55,76). Our results in cultured endothelial cells treated with LDL, ox-LDL or LPC also showed that xanthones significantly decreased the level of ADMA concomitantly with an improvement in DDAH activity (36)(37)(38)(39). As mentioned above, xanthones can significantly attenuate the levels of lipid peroxides and of TNF-á induced by ox-LDL (36)(37)(38)(39).…”

Section: Mechanism Of the Inhibitory Effect Of Xanthones On Adma Levelsmentioning

confidence: 66%

“…This effect is followed by an acute inflammatory response, such as an increase of ICAM-1 expression at 6 to 12 h after injection of LDL, which leads to endothelial dysfunction concomitantly with an elevation of ADMA level (8,42). Pretreatment with xanthones attenuated the endothelial dysfunction and the elevation of ADMA level elicited by injection of LDL in vivo (37). Moreover, in cultured endothelial cells xanthones inhibited the increase in the release of LDH, the upregulation of MCP-1 expression and the enhancement of monocytes adhesion concomitantly with a reduction of ADMA levels (36,39).…”

Section: Xanthones Protect Against Endothelial Dysfunction By Reducinmentioning

confidence: 99%

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Pharmacological Effects of Xanthones as Cardiovascular Protective Agents

Jiang

Dai

2004

Cardiovascular Drug Reviews

Self Cite

101

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Many epidemiological studies indicate that consumption of dietary polyphenolic compounds is beneficial in the prevention of cardiovascular diseases. Xanthones are a class of polyphenolic compounds that commonly occur in plants and have been shown to have extensive biological and pharmacological activities. Recently, the pharmacological properties of xanthones in the cardiovascular system have attracted great interest. Xanthones and xanthone derivatives have been shown to have beneficial effects on some cardiovascular diseases, including ischemic heart disease, atherosclerosis, hypertension and thrombosis. The protective effects of xanthones in the cardiovascular system may be due to their antioxidant, antiinflammatory, platelet aggregation inhibitory, antithrombotic and/or vasorelaxant activities. In particular, the antagonism of endogenous nitric oxide synthase inhibitors by xanthones may represent the basis for improved endothelial function and for reduction of events associated with atherosclerosis.

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Section: Mechanism Of the Inhibitory Effect Of Xanthones On Adma Levelsmentioning

confidence: 66%

Section: Mechanism Of the Inhibitory Effect Of Xanthones On Adma Levelsmentioning

confidence: 66%

Section: Xanthones Protect Against Endothelial Dysfunction By Reducinmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacological Effects of Xanthones as Cardiovascular Protective Agents

Jiang

Dai

2004

Cardiovascular Drug Reviews

Self Cite

101

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“…They can act as metal chelators [35], free radical scavengers [31][32][33]35,[39][40][41]49,51,[54][55][56][57][58][59][60][61][62][63][64][65][66][67], as well as inhibitors of lipid peroxidation [31,33-35, 39,43,64,66, 68-70]. These properties have been implicated with their hepatoprotective [64,71,72], antiinflammatory [43,48,54], and cancer chemopreventive actions [50,69]. Table 1 lists the effects of xanthonic derivatives on crucial enzyme systems.…”

Section: Biological Activitiesmentioning

confidence: 99%

Xanthone Derivatives: New Insights in Biological Activities

Pinto¹,

Sousa

Nascimento

2005

CMC

450

232

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Xanthones or xanthen-9H-ones (dibenzo-gamma-pirone) comprise an important class of oxygenated heterocycles whose role is well-known in Medicinal Chemistry. The biological activities of this class of compounds are associated with their tricyclic scaffold but vary depending on the nature and/or position of the different substituents. In this review, an array of biological/pharmacological effects is presented for both natural and synthetic xanthone derivatives, with an emphasis on some significant studies on structure-activity relationships. The antitumor activity of some xanthones as well as the related targets, particularly PKC modulation studies, is also discussed in detail. Examples of the "hit" compounds involved in cancer therapy, namely DMXAA, psorospermin, mangiferin, norathyriol, mangostins, and AH6809, a prostanoid receptor antagonist, are also mentioned. Finally, a historical perspective of these xanthonic derivatives, their relevance as therapeutic agents and/or their uses as pharmacological tools and as extract components in folk medicine are also highlighted.

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“…Moreover, bellidifolin exhibited lower the heart rate, and hypoglycemic activities (Wu et al, 2011, Tian et al, 2010. DMB have many biological activities, such as protects the myocardium against damage due to ischemia-reperfusion in rats, inhibits the increased adhesion of monocytes to endothelial cells, and protects endothelial damage (Jiang et al, 2002(Jiang et al, , 2003(Jiang et al, , 2004.…”

Section: Introductionmentioning

confidence: 99%

Determination and pharmacokinetic study of four xanthones in rat plasma after oral administration of Gentianella acuta extract by UHPLC–ESI–MS/MS

Wang

et al. 2015

Journal of Ethnopharmacology

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Demethylbellidifolin preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level

Cited by 23 publications

References 38 publications

Pharmacological Effects of Xanthones as Cardiovascular Protective Agents

Pharmacological Effects of Xanthones as Cardiovascular Protective Agents

Xanthone Derivatives: New Insights in Biological Activities

Determination and pharmacokinetic study of four xanthones in rat plasma after oral administration of Gentianella acuta extract by UHPLC–ESI–MS/MS

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