Demethylchlortetracycline

Finland, Maxwell; Garrod, L. P.

doi:10.1136/bmj.2.5204.959

Cited by 21 publications

(8 citation statements)

References 14 publications

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“…Strains resistant to the tetracycline group showed an increase from 11.9-8.8% to 30.3 to 21.4%, chlortetracycline was more effective than tetracycline and oxytetracycline. Such a finding is in agreement with the results of other investigators (15). Strains resistant to erythromycin showed an increase from 0.5% to 10.5%.…”

Section: Discussionsupporting

confidence: 83%

State of Susceptibility to Antibiotics of 832 Bacterial Strains Isolated in Istanbul in 1960–1961

et al. 1964

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Section: Discussionsupporting

confidence: 83%

State of Susceptibility to Antibiotics of 832 Bacterial Strains Isolated in Istanbul in 1960–1961

et al. 1964

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“…Volume distribution (Vdar,,) values were found to be 1.59 + 0.18 L/kg in goats (Table I), 1.996 f 0.22 L/kg in cows and ewes (Ziv and Suhnan, 1974) and 1.79 L/kg in man (Kunin et al, 1959;Finland and Garrod, 1960). These similar values indicate that demeclocycline is well distributed throughout the body in all these species.…”

Section: Discussionsupporting

confidence: 64%

Disposition kinetics and distribution of demeclocycline in various biological fluids in female goats

1989

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A pharmacokinetic study of demeclocycline was carried out following intravenous administration at 5 mg/kg body weight in lactating goats. Demeclocycline appeared within 5 min in plasma, interstitial fluid (isf) and urine, while it appeared at 1 h in milk. Peak concentrations of 21.70 +/- 4.06, 2.67 +/- 0.23, 5.65 +/- 0.45 and 82.23 +/- 10.06 micrograms/ml were attained at 5 min and at 6, 8 and 8 h in plasma, isf, milk and urine respectively. A potentially therapeutic concentration of greater than or equal to 0.5 micrograms/ml was maintained from 5 min-36 h, 30 min-30 h, 1-36 h and 5 min-48 h in plasma, isf, milk and urine respectively. The drug was detectable in all the above biological fluids for at least 48 h. A low distribution half life (t1/2 alpha) of 0.44 +/- 0.04 h and a high elimination half life (t1/2 beta) of 19.24 +/- 1.22 h denote rapid distribution but very slow elimination of the drug in goats. A high tissue plasma concentration ratio [K12:(K21-beta)] of 5.12 +/- 0.97 during the elimination phase and a Vdarea of 1.59 +/- 0.18 L/kg indicate uniform distribution of demeclocycline in the tissues and body fluids of goats. The dosage regimen for maintaining minimum plasma concentration (Cp infinity min = MIC) of 0.5, 1.0 and 1.5 micrograms/ml at selected dosage intervals of 12 and 24 h was also calculated.

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“…All strains except one were completely inhibited at concentrations ranging from less than 0-02 to 2 ,ug./ml. The apparent superiority of this tetracycline may have been due to its much greater stability in solution over 7 days at 370 C. (Finland & Garrod, 1960).…”

Section: Discussionmentioning

confidence: 99%

Anin vitrocomparison of the effect of some antibacterial, antifungal and antiprotozoal agents on various strains ofMycoplasma(pleuropneumonia–like organisms: P.P.L.O.)

Newnham

Chu

1965

J. Hyg.

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A study was made in liquid medium over 7 days at 37° C. of the inhibitory action of nineteen antibacterial, antifungal and antiprotozoal drugs on twenty strains ofM. gallisepticum, eight other avian mycoplasmata, six mammalian mycoplasmata, two saprophytic mycoplasmata and the L-form ofStreptobacillus moniliformis(L–1).The twenty strains ofM. gallisepticumfrom Britain and other countries showed a similar range of drug sensitivity except where resistant strains were included. Tylosin and demethylchlortetracycline appeared to have the highest inhibitory action, followed by erythromycin, spiramycin, tetracycline, chlortetracycline, oxytetracycline and ethidium bromide. A ‘Zone Phenomenon’ frequently occurred with sodium aurothiomalate, inhibition often being observed between 0·1 and 2·0 μg./ml. Polymixin and nystatin had no inhibitory effect on the growth of any mycoplasmata tested. With the exception of erythromycin and streptomycin in some cases, the pattern of sensitivity observed with the mycoplasmata of diverse origin was similar to that ofM. gallisepticum, most strains, however, being somewhat more resistant thanM. gallisepticumto many of the drugs.

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Demethylchlortetracycline

Cited by 21 publications

References 14 publications

State of Susceptibility to Antibiotics of 832 Bacterial Strains Isolated in Istanbul in 1960–1961

State of Susceptibility to Antibiotics of 832 Bacterial Strains Isolated in Istanbul in 1960–1961

Disposition kinetics and distribution of demeclocycline in various biological fluids in female goats

Anin vitrocomparison of the effect of some antibacterial, antifungal and antiprotozoal agents on various strains ofMycoplasma(pleuropneumonia–like organisms: P.P.L.O.)

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