Demineralized Bone Matrix: Maximizing New Bone Formation for Successful Bone Implantation

Wolfinbarger, Lloyd; Eisenlohr, Liisa M.; Ruth, Katrina

doi:10.1007/978-1-59745-239-7_6

Cited by 10 publications

(18 citation statements)

References 36 publications

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“…2, [11][12][13][14][15][16][17][18][19] One of the options tried was the use of human tissue transplants from another person. 20 -25 This clinical evolution has led to the appearance of human tissue donor banks and different types of materials used for grafts.…”

mentioning

confidence: 99%

Five-Year Results of Implants Inserted Into Freeze-Dried Block Allografts

Novell¹,

Novell-Costa²,

Ivorra³

et al. 2012

Implant Dentistry

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mentioning

confidence: 99%

Five-Year Results of Implants Inserted Into Freeze-Dried Block Allografts

Novell¹,

Novell-Costa²,

Ivorra³

et al. 2012

Implant Dentistry

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“…So, it is suited for filling bone defects and cavities and can also be used with a carrier in combination with autologous bone marrow. 3 Approximately 60% of the bone graft substitutes currently available involve ceramics, either alone or in combination with another material. These include calcium sulfate, hydroxyapatite (HA), 4 and tricalcium phosphate.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of Fronto-Orbital and Nasal Defects With Compound Epoxied Maleic Acrylate/Hydroxyapatite Implant Prefabricated With a Computer Design Program

Chai

Zhang²,

Ma³

et al. 2011

Annals of Plastic Surgery

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The repair of fronto-orbital nasal bone defects may be a troublesome problem to plastic surgeons. This report aims to present the results of reconstruction of fronto-orbital nasal bone defects with the prefabrication of epoxied maleic acrylate/hydroxyapatite compound (EH compound) using 3-dimensional (3D) imaging data and computer-assisted manufacturing techniques, sometimes combined with autogenous bone to repair nasal defect. Helical computed tomography data were used to create a 3D model of the patient's skull. On the basis of these data, the individual shape of the implant was created by a computer-aided design/computer-aided manufacturing program. A rapid prototyping system was applied for production of the physical models. A total of 12 patients with traumatic fronto-orbital nasal defects were included in this study. The patients followed up for 1 to 24 months. The satisfactory results, such as excellent symmetry, stability, and normal fronto-orbital contours were obtained for all patients. The operating time was short without any complications. The depression of the region of fronto-orbital nasal bone defects always achieved an attractive or satisfactory prominence that was in balance and harmony with other facial features of all the patients. This method allows accurate fabrication of the implant. It improves the surgical techniques and reduces the risk of a second intervention, with improved aesthetic outcomes.

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“…The L-MDF samples discussed in this chapter were demineralized using a proprietary and patented process targeted at achieving an optimized level of residual calcium of 1-4%. Furthermore, the presence of specific proteins in DBM is frequently associated with its osteoinductive potential as growth factors can provide signals that direct cellular behavior [18,22,24]. In particular, BMP-2 and 7 are important for bone growth as they are known for their "ability to stimulate differentiation of MSCs to osteochondroblastic lineage" [18].…”

Section: Discussionmentioning

confidence: 99%

Cell Attachment and Osteoinductive Properties of Tissue Engineered, Demineralized Bone Fibers for Bone Void Filling Applications

McLean¹,

Carter²,

Sohoni³

et al. 2021

Clinical Implementation of Bone Regeneration and Maintenance

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Demineralized bone matrices (DBMs) have been used in a wide variety of clinical applications involving bone repair. Ideally, DBMs should provide osteoinductive and osteoconductive properties, while offering versatile handling capabilities. With this, a novel fiber technology, LifeNet Health-Moldable Demineralized Fibers (L-MDF), was recently developed. Human cortical bone was milled and demineralized to produce L-MDF. Subsequently, the fibers were lyophilized and terminally sterilized using low-dose and low-temperature gamma irradiation. Using L929 mouse fibroblasts, L-MDF underwent cytotoxicity testing to confirm lack of a cytotoxic response. An alamarBlue assay and scanning electron microscopy demonstrated L-MDF supported the cellular function and attachment of bone-marrow mesenchymal stem cells (BM-MSCs). Using an enzyme-linked immunosorbent assay, L-MDF demonstrated BMP-2 and 7 levels similar to those reported in the literature. In vivo data from an athymic mouse model implanted with L-MDF demonstrated the formation of new bone elements and blood vessels. This study showed that L-MDF have the necessary characteristics of a bone void filler to treat osseous defects.

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Demineralized Bone Matrix: Maximizing New Bone Formation for Successful Bone Implantation

Cited by 10 publications

References 36 publications

Five-Year Results of Implants Inserted Into Freeze-Dried Block Allografts

Five-Year Results of Implants Inserted Into Freeze-Dried Block Allografts

Reconstruction of Fronto-Orbital and Nasal Defects With Compound Epoxied Maleic Acrylate/Hydroxyapatite Implant Prefabricated With a Computer Design Program

Cell Attachment and Osteoinductive Properties of Tissue Engineered, Demineralized Bone Fibers for Bone Void Filling Applications

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