Demographic Characteristics and Functional Performance of the Kidneys and Hearts of Patients with Acute Tramadol Toxicity

Abstract

Tramadol-induced seizures were not found to be related to age, gender, or dosage. This complication can lead to cardiac and renal complications in individuals on tramadol experiencing seizures. This result indicates that stricter restrictions should be imposed on the distribution and administration of the drug tramadol.

Rhabdomyolysis and acute kidney injury due to suicide attempt with tramadol: A rare case report

“…Renal failure is a rare complication of poisoning that can be directly or indirectly caused by TR following seizures and rhabdomyolysis due to poisoning. 18 In a study conducted in 2019 by Abdul Rahman et al, it was shown that the risk of suicide among adolescents with substance use disorders is high and that there is a direct relationship between substance use disorders and suicidal ideation. Tramadol users also accounted for 40% of the sample.…”

A review on tramadol toxicity: mechanism of action, clinical presentation, and treatment

“…None of the studies found a relationship between the ECG changes and the amount of drug ingested, or a history of tramadol use. In contrast, some studies proposed that tramadol induced seizure could lead to cardiac complications and reported higher levels of troponin I and creatine phosphokinase in patients experiencing seizures, compared to non-seizure subjects [73].…”

“…Patients with recurrent seizures ingested, on average double the tramadol dose of single seizure patients [10]. In contrast, some studies reported a non-significant difference of serum tramadol concentrations between patients with seizures and those without seizures [2,17,73,74].…”

“…In addition, blood urea nitrogen (BUN and creatinine levels remained unchanged [52]. It has been proposed that tramadol induced seizure can lead to renal complications and kidney biochemical parameters which were reported to be significantly higher in patients experiencing seizures compared to the non-seizure patients [73].…”

A Screen-Printed Electrode Modified With Graphene/Co3O4 Nanocomposite for Electrochemical Detection of Tramadol

“…Overdosing on tramadol can cause vomiting, problems in the central nervous system (CNS) and respiratory system, depression, dizziness, nausea, coma, tachycardia, and seizure (Scott and Perry, 2000). Tramadol is rapidly and nearly completely absorbed in oral usage, but excretion of roughly 10-30% of the parent drug happens un-metabolized in urine (Mohammadpour et al, 2019). Thus, for reasons related to treatment and the drug, it is of special significance to propose a sensitive technique to measure specimens containing of tramadol.…”