Demographic differences in Down syndrome livebirths in the US from 1989 to 2006

Egan, James; Smith, Kathleen; Timms, Diane; Bolnick, Jay M.; Campbell, Winston A.; Benn, Peter

doi:10.1002/pd.2702

Cited by 28 publications

(27 citation statements)

References 13 publications

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“…Previous US studies have used birth certificate data 13,30,31 or data from birth defects surveillance systems 1–3,13 to estimate the prevalence of Down syndrome among births in the US population. 1–3,9 Our 1979–2006 estimates of the live birth prevalence of Down syndrome were approximately 16% larger than those presented elsewhere.…”

Section: Discussionmentioning

confidence: 99%

Current Estimate of Down Syndrome Population Prevalence in the United States

Presson¹,

Partyka²,

Jensen³

et al. 2013

The Journal of Pediatrics

347

237

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Objective To calculate a reliable estimate of the population prevalence of Down syndrome in the US. Study design The annual number of births of infants with Down syndrome were estimated by applying published birth prevalence rates of Down syndrome by maternal age to US data from the Centers for Disease Control and Prevention for the years for which births by maternal age were available (1940–2008). Death certificate data for persons with Down syndrome were available for the years 1968–2007. We estimated the number of people with Down syndrome on January 1, 2008, using a life table approach based on proportions of deaths by age. Monte Carlo sampling was used to create 90% uncertainty intervals (UIs) for our estimates. Results We estimated the January 1, 2008, population prevalence of Down syndrome as approximately 250 700 (90% UI, 185 900–321 700) based on proportions of deaths by age from the most recent 2 years (2006–2007) of death certificate data. This estimate corresponds to a prevalence of 8.27 people with Down syndrome per 10 000 population (90% UI, 6.14–10.62). Conclusion Our estimate of Down syndrome prevalence is roughly 25%–40% lower than estimates based solely on current birth prevalence. The results presented here can be considered a starting point for facilitating policy and services planning for persons with Down syndrome.

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Section: Discussionmentioning

confidence: 99%

Current Estimate of Down Syndrome Population Prevalence in the United States

Presson¹,

Partyka²,

Jensen³

et al. 2013

The Journal of Pediatrics

347

237

View full text Add to dashboard Cite

show abstract

“…8,9 Devemos ressaltar também que, ao conhecermos os tipos e comportamento das anomalias congénitas em recém-nascidos de adolescentes, podemos tomar medidas profiláticas visando diminuir a sua incidência.…”

Section: Discussionunclassified

“…8,9 Em relação às anomalias congénitas não cromossómicas, observou-se que recém-nascidos de mulheres adolescentes (14 -19 anos) apresentam diferentes anomalias em relação aos recém-nascidos de mulheres com idade avançada (35 -40 anos).…”

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Anomalias Congénitas Identificadas ao Nascimento em Recém-Nascidos de Mulheres Adolescentes

Reis¹,

Júnior²,

Guazzelli³

et al. 2015

Acta Med Port

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Acta Med Port 2015 Nov-Dec;28(6):708-714 RESUMOIntrodução: Analisar a prevalência das anomalias congénitas, detetadas no nascimento, entre filhos de gestantes adolescentes, enfatizando os tipos mais comuns e a época do diagnóstico. Material e Métodos: Estudo retrospetivo do tipo censo, no qual foram analisados todos recém-nascidos, vivos ou mortos, com peso superior a 500 g, de mulheres que tiveram o parto no Hospital São Paulo num período de seis anos. Os produtos da conceção portadores de anomalias foram identificados no período pré-natal ou através do exame físico pós-natal, segundo os critérios do Estudo Colaborativo Latino-Americano das Malformações Congênitas. Os resultados são apresentados de forma descritiva através de valores absolutos e relativos, calcula-se a prevalência das anomalias e comparam-se os diferentes grupos recorrendo a testes não paramé-tricos.Resultados: Foram analisadas 6 257 gestações, das quais 577 resultaram em recém-nascidos com alguma anomalia congénita identificada no nascimento (prevalência de 9,2%). Do total de gestações, 907 eram de adolescentes (idade inferior a 20 anos), para as quais se verificou uma prevalência de anomalias nos recém-nascidos de 9,9%. Comparando os recém-nascidos de adolescentes com os das mulheres com idade superior a 20 anos, apenas se encontrou diferença estatisticamente significativa para a prevalência dos defeitos do tubo neural (p = 0,027). Discussão: Observamos uma alta taxa de partos em adolescentes, acima das taxas dos países desenvolvidos. Observamos também alta frequência de anomalias congénitas em recém-nascidos, provavelmente por sermos um serviço terciário de referência. A elevada prevalência dos defeitos do tubo neural entre grávidas jovens pode ser explicada pela não suplementação pré-concecional de ácido fólico em gravidezes não planeadas, como é característico nas adolescentes. Conclusão:A prevalência e momento do diagnóstico das anomalias congénitas em recém-nascidos apresentam comportamentos semelhantes entre grávidas com idade inferior ou superior a 20 anos, exceto para os defeitos do tubo neural, de maior prevalência nos recém-nascidos das grávidas adolescentes. Palavras-chave: Adolescente; Anomalias Congénitas; Gravidez. ABSTRACT Introduction:To analyze the prevalence of congenital anomalies detected at birth among children of pregnant adolescents, emphasizing the most common types and the time of diagnosis. Material and Methods: Retrospective study of type census, in which were analyzed in all newborns, living or dead, weighing more than 500 g of women who gave birth at Hospital São Paulo in a period of six years. The fetuses bearing anomalies were identified prenatally or through postnatal physical examination period, according to the criteria of the Latin American Collaborative Study of Congenital Malformations. The results were expressed descriptively using absolute and relative values, the prevalence of anomalies was calculated, as well as the comparison between groups using nonparametric tests. Results: We analyzed 6 257 pregnan...

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“…38 One concern that arises in discussions of trait selection, prenatal testing, and the potential for gene therapy or gene editing is the possibility that allowing parents the choice to control aspects of their child's genetic inheritance (procreative autonomy) could create expectations of this sort of control or even obligations to ''create the best children'' in what has been called procreative beneficence. 39,40 These are among the specific concerns about eugenics expressed by the bioethics community and the public, but perhaps the most deeply felt uneasiness is conceptual: the sense that in identifying some individuals and their traits as ''unfit,'' we experience a collective loss of our humanity.…”

Section: Ethical Issues Related To the Success Of Human Germline Genomentioning

confidence: 99%

“…In turn, reduced incidence and reduced sense of shared risk could affect the resources available to individuals and families dealing with genetic conditions. 38,43,44 Accordingly, we have come to an agreement on the positions below and include clarifications and elaborations:…”

Section: Ethical Issues Related To the Success Of Human Germline Genomentioning

confidence: 99%