Demographic profile, clinicopathological spectrum, and treatment outcomes of primary central nervous system tumors: Retrospective audit from an academic neuro-oncology unit

Gupta, Tejpal; Epari, Sridhar; Moiyadi, Aliasgar; Shetty, Prakash; Goda, Jayant Sastri; Krishnatry, Rahul; Chinnaswamy, Girish; Vora, Tushar; Menon, Hari; Patil, Vijay; Sahay, Ayushi; Bano, Nazia; Jalali, Rakesh

doi:10.4103/ijc.ijc_543_17

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…Only explanation of this could be long duration of data collection in our HBBTR (7 years) as compared with TMH (1 year) and NIMHANS (5 years). 22 Further in our cohort, tumors in pediatric population (0-18 years) accounted for 15.5%, matching with Indian data with minor differences. While in CBTRUS report (0-19 years), they comprised of 6.6% of overall CNS tumors; this could be attributed to the sizeable percentage of young people in our country as compared with the US population.…”

Section: Discussionsupporting

confidence: 86%

Epidemiological Profiling and Trends of Primary Intracranial Tumors: A Hospital-Based Brain Tumor Registry from a Tertiary Care Center

Meel

Choudhary

Kumar

et al. 2021

JNRP

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Background and Objectives Hospital-based cancer registry is an essential tool for augmentation of the standard of care, administration motive, and resource for population-based cancer registries. Here, we presented hospital-based brain tumor registry (HBBTR) to outline a comprehensive epidemiological data, both clinical and histopathological, as well as trends of central nervous system tumors. In addition, we compare this data with national brain tumor data as well as an international brain tumor registry. Materials and Methods For the generation of this 7-year HBBTR data of all primary intracranial tumors operated, diagnosed, and registered at the Department of Pathology, Sawai ManSingh, between January 1, 2013 and December 31, 2019, was collected, analyzed, and compared with Tata Memorial Hospital, National Institute of Mental Health and Neurosciences, and Central Brain Tumor Registry of the United States. Results A total of 3,526 patients were of primary intracranial tumors. Out of which, male patients were 1,982 (56.2%), while 1,544 (43.8%) were female patients. Maximum proportion of tumors was in fifth decade. Overall, pediatric and adult patients constituted of 15.5 and 84.5% of the cases, respectively. Among all primary intracranial tumors, meningiomas (20%) were most common followed by glioblastoma multiformat (18%) and least common were germ cell tumors (0.1%) followed by pineal tumors (0.3%). In pediatric cohort astrocytic tumors (30.1%) are most common followed by embryonal tumors (20.8%), while in adults meningiomas (23.1%) were most common followed by glioblastomas (20.3%). Our registry showed similar trends of tumors with national data as compared with international data in median age of presentation. Conclusion This HBBTRs provide prevalence of primary intracranial tumors at a tertiary care center and could be a part of population-based registry.

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Section: Discussionsupporting

confidence: 86%

Epidemiological Profiling and Trends of Primary Intracranial Tumors: A Hospital-Based Brain Tumor Registry from a Tertiary Care Center

Meel

Choudhary

Kumar

et al. 2021

JNRP

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“…Central nervous system tumours are unique rare neoplasms accounting for 1-2% of total malignancies. 1 As per the reports of GLOBOCAN 2020, it has ranked to 20 th position among all cancers, with an estimated 308 102 new cases worldwide. It accounts for 2.5% of all cancer related deaths with ranking of 13 among all cancers.…”

Section: Introductionmentioning

confidence: 99%

Analysis of histopathological spectrum of intracranial central nervous system tumours in a tertiary care hospital

2021

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Background: Descriptive epidemiology of intracranial central nervous system (CNS) tumours is a significant part of tumour studies which provides information on magnitude and distribution of the lesions. The objective of this study is to provide an overview of frequency of intracranial CNS tumours with comparison with national and international data.Methods: In this retrospective study 101 intracranial CNS tumours diagnosed over a period of 4 years were included. Histological diagnosis of tumours was confirmed and they were classified according to revised WHO classification of CNS tumours 2016. Frequencies of tumours in accordance to age, gender, location, laterality and grades were evaluated.Results: Total 101 cases including 59 (58.42%) males and 42 (41.58%) females were studied. Paediatric and adult cases accounted for 17 (16.83%) and 84 (83.17%), respectively. Most tumours were noted in the 6th decade. Out of total cases, 91 (90.1%) were primary intracranial CNS tumours and 10 (9.9%) were metastatic tumours. Most common tumours were astrocytoma followed by meningioma. Among children, astrocytoma (41.18%), medulloblastomas (41.18%), ependymomas (11.76%) and meningiomas (5.88%) were the reported lesions. In adults, astrocytoma (39.29%), meningiomas (23.81%), metastatic tumours (11.90%), ependymomas (8.33%), hemangioblastomas (5.95%) and schwannomas (4.76%) were common. Glioblastomas were the commonest astrocytoma. WHO grade I tumours were commonest followed by grade IV. Conclusions: The study gives a glimpse of prevalence of intracranial central nervous system tumours forming a baseline profile based primarily on the histopathological diagnosis at rural tertiary care hospital.

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“…Central nervous system (CNS) tumors are rare, and these tumors are the second most common type of malignancy in children. 1 Accurate histopathological evaluation is essential in deciding the treatment for CNS tumors. Molecular diagnostics are helpful in therapeutic decision-making and assessing the prognosis.…”

Section: Introductionmentioning

confidence: 99%

Challenges in the Histopathologic Diagnosis of Brain Tumors: An Institutional Experience in a Series of Cases

Shetty

Prasad

Shruthi

et al. 2022

Journal of Health and Allied Sciences NU

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Background Central nervous system (CNS) tumors are relatively rare. However, brain tumors are one of the leading causes of cancer-related morbidity and mortality. Accurate histopathologic diagnosis and molecular diagnostics are critical for managing these patients. Histopathology plays a vital role in diagnosis, but clinical and radiological information is also crucial while evaluating brain tumors. Materials and Methods A cross-sectional observational study was performed for a period of 1 year in the pathology department of a tertiary hospital. All the brain biopsies sent for histopathological analysis were analyzed, and among which five brain biopsy tissue posing the diagnostic dilemma in conventional histopathology were included in the study. Immunohistochemistry was performed wherever necessary. Results During the study period, we encountered 32 cases of brain biopsy. Five cases posing diagnostic challenges in histopathological diagnosis were included in the study. Expert opinions of neuropathologists were taken in all of these cases. We reviewed the cases for the diagnostic difficulties. A review of all these cases has impacted further treatment. Conclusion In this case series, we present five CNS tumors with a diagnostic dilemma in histopathological diagnosis where clinicoradiological correlation, immunohistochemistry, and expert opinion helped in the definitive diagnosis revealing the importance of a multidisciplinary approach for the better management of patients.

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Demographic profile, clinicopathological spectrum, and treatment outcomes of primary central nervous system tumors: Retrospective audit from an academic neuro-oncology unit

Cited by 7 publications

References 21 publications

Epidemiological Profiling and Trends of Primary Intracranial Tumors: A Hospital-Based Brain Tumor Registry from a Tertiary Care Center

Epidemiological Profiling and Trends of Primary Intracranial Tumors: A Hospital-Based Brain Tumor Registry from a Tertiary Care Center

Analysis of histopathological spectrum of intracranial central nervous system tumours in a tertiary care hospital

Challenges in the Histopathologic Diagnosis of Brain Tumors: An Institutional Experience in a Series of Cases

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