Demographics and outcomes of eccrine porocarcinoma: results from the National Cancer Database

Behbahani, Sara; Malerba, Stefano; Karanfilian, Katrice M.; Warren, Christopher J.; Alhatem, Albert

doi:10.1111/bjd.18874

Cited by 20 publications

(34 citation statements)

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“…[9][10][11] The most common location for PC is the lower limbs, followed by the head, scalp, and upper limbs. 4,12 Occasionally, the tumor may appear on the face (eyelids, ear, or lips) 13 or the genitalia. 14 Clinically, PC can present as a slow or rapidly growing ulcerated nodule or verrucous plaque, ranging from 1 to 20 cm in size.…”

Section: Introductionmentioning

confidence: 99%

“…PC is a typical cancer of the elderly and usually occurs between the sixth and seventh decades of life 7–9 , with a debatable gender predilection 9–11 . The most common location for PC is the lower limbs, followed by the head, scalp, and upper limbs 4,12 . Occasionally, the tumor may appear on the face (eyelids, ear, or lips) 13 or the genitalia 14 …”

Section: Introductionmentioning

confidence: 99%

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Porocarcinoma: an epidemiological, clinical, and dermoscopic 20‐year study

et al. 2022

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Background Porocarcinoma (PC) is a rare cutaneous adnexal tumor with a variable metastatic potential. Given the paucity of data, guidelines and specific recommendations for PC are not yet well‐established. In this study, we evaluate the disease‐specific characteristics and outcome of this rare and often underestimated tumor. Materials and method A retrospective study of the epidemiological, clinical, and dermoscopic characteristics among cases of histopathologically diagnosed PC, collected from the database of two skin cancer clinics in Italy (Firenze, Pistoia) from 2000 to 2020, was conducted. Results Among the 52 patients with 53 tumors, 31 were men (59.6%) and 21 were women (40.4%) with an age range of 49–96 years (median age 82 years). The most common locations were the head/neck region in men (34% in men vs. 17% in women) and the lower limb in women (17% in women vs. 9% in men). Forty‐eight cases (91%) underwent local excision. Of these patients, two (4%) experienced local recurrence, and one (2%) developed a second PC on a different anatomical site 1 month after the primary tumor's excision. Lymph node metastases were present in three cases (6%). Two of them have been treated surgically with adjuvant radiotherapy (both are disease‐free after a 2‐year follow‐up period), whereas the third case developed visceral metastases followed by PC‐related death. Conclusions This study, with 52 patients with 53 tumors covering a follow‐up period of more than 5 years, shows a less aggressive behavior of PC with 4% local recurrence, 6% nodal metastases, and 2% mortality.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Porocarcinoma: an epidemiological, clinical, and dermoscopic 20‐year study

et al. 2022

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“…First described in 1963 10 , EPC has been considered to be an aggressive skin tumour with a high probability of recurrence 6 , 11 , 12 . Recent studies have revealed its low mortality rate and called the general belief of its aggressiveness into question 2 , 5 , 13 . However, the mortality rate is high in cases with metastatic dissemination 6 , 14 .…”

Section: Introductionmentioning

confidence: 99%

UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma

Puttonen

Isola

Ylinen³

et al. 2022

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Eccrine porocarcinoma (EPC) is a rare malignant adnexal tumour of the skin. Part of EPCs develop from their benign counterpart, poroma (EP), with chronic light exposure and immunosuppression hypothesized to play a role in the malignant transformation. However, the impact of chronic light exposure on the microenvironment of EPCs and EPs has not been investigated yet. Although the clinical relevance of tumour infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) has been established in various tumours, their distribution and significance in EPCs and EPs is still poorly understood. We characterized the distribution of TILs and TLSs using CD3, CD4, CD8, CD20 immunohistochemistry in a cohort of 10 EPCs and 49 EPs. We then classified our samples using solar-elastosis grading, analyzing the influence of ultraviolet (UV) damage on TIL density. A negative correlation between UV damage and TIL density was observed (CD4 r = −0.286, p = 0.04. CD8 r = −0.305, p = 0.033). No significant difference in TIL density was found between EPCs and EPs. TLS was scarse with the presence rate 10% in EPCs and 8.3% in EPs. The results suggest that UV has an immunosuppressive effect on the microenvironment of EPCs and EPs.

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“…There is an even gender distribution or a slight male predominance [6] , [7] . The disease commonly affects whites and is often diagnosed in the seventh decade of life [6] , [8] , [9] . High radiation dose, prolonged sunlight exposure, immunosuppression, and other pre-existing dermatological pathology are the main risk factors for porocarcinoma [6] .…”

Section: Introductionmentioning

confidence: 99%