Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections

Iwamoto, Norihiko; Nishiyama, Etsuko; Ohwada, Jiro; Arai, Heii

doi:10.1016/0304-3940(94)90035-3

Cited by 128 publications

(70 citation statements)

References 17 publications

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“…The chronic infusion of IL-1β and TNF-α can also harm the cholinergic neurons that originate within the nucleus basalis (29). Data obtained from postmortem AD brains showed high concentrations of acute phase inflammatory reactants, such as CRP and proinflammatory cytokines, in senile plaques and neurofibrillary tangles (30,31). There is also evidence supporting the hypothesis that inflammatory processes may take place in the early stages of AD (4,32,33).…”

Section: Discussionmentioning

confidence: 92%

Alzheimer disease, inflammation, and novel inflammatory marker: resistin

Kızılarslanoğlu¹,

Kara²,

Yeşil³

et al. 2015

Turk J Med Sci

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Background/aim: Inflammation may play an important role in Alzheimer disease (AD) pathogenesis. A growing amount of evidence indicates that resistin has hallmark regulatory functions such as inflammatory states. The aim of this study was to determine whether plasma resistin levels would be useful in the diagnosis of patients with AD and to investigate the relationships between resistin and other inflammatory markers such as hs-CRP and TNF-α. Materials and methods:In this cross-sectional study, 38 AD patients and 32 control subjects with normal cognitive function aged 65 years and over were included. The diagnosis of AD was made according to DSM-IV and NINCDS-ADRDA criteria. Serum levels of resistin were measured with an enzyme-linked immunosorbent assay method using the human resistin E50 kit. Results:The median resistin level of AD patients was significantly higher than in the control group (86.3 vs. 70.8 pg/mL, P = 0.002). Overall accuracy of resistin in determining AD was 70.66%, with sensitivity, specificity, PPV, and NPV of 75.0%, 65.5%, 73.0%, and 67.9%, respectively. There was no statistically significant difference between AD patients and control subjects with respect to hs-CRP and TNF-α levels. Conclusion:Resistin levels may be considered as a predictor of AD and it may predict activation of the immune system in AD pathophysiology.

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Section: Discussionmentioning

confidence: 92%

Alzheimer disease, inflammation, and novel inflammatory marker: resistin

Kızılarslanoğlu¹,

Kara²,

Yeşil³

et al. 2015

Turk J Med Sci

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“…Here, we were not able to address the observed plasma‐derived relationships, such as A β and hs‐CRP, in the CNS of METSIM and FINGER individuals, owing to lack of systematic A β pathology assessments. CRP has been demonstrated to localize to A β plaques in the brain of AD patients,51, 52 but its role in the CNS is not well known. In this study, we did not observe any alterations in the brain CRP mRNA levels at different stages of AD‐related neurofibrillary pathology among individuals with or without an APOE ɛ 4 allele.…”

Section: Discussionmentioning

confidence: 99%

Decreased plasma C‐reactive protein levels in APOE ε4 allele carriers

Martiskainen

Takalo

Solomon

et al. 2018

Ann Clin Transl Neurol

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ObjectiveApolipoprotein E (APOE) ε4 allele is a well‐established risk factor in Alzheimer's disease (AD). Here, we assessed the effects of APOE polymorphism on cardiovascular, metabolic, and inflammation‐related parameters in population‐based cohorts.MethodsAssociation of cardiovascular, metabolic, and inflammation‐related parameters with the APOE polymorphism in a large Finnish Metabolic Syndrome in Men (METSIM) cohort and Finnish Geriatric Intervention study to prevent cognitive impairment and disability (FINGER) were investigated. Brain‐specific effects were addressed in postmortem brain samples.ResultsIndividuals carrying the APOE ε4 allele displayed significantly elevated serum/plasma LDL cholesterol and apolipoprotein B levels. APOE ε3ε4 and ε4ε4 significantly associated with lower levels of plasma high‐sensitivity C‐reactive protein (hs‐CRP). Plasma amyloid‐β 42 (Aβ42) and reduced hs‐CRP levels showed an association independently of the APOE status.InterpretationThese data suggest that the APOE ε4 allele associates with lower levels of hs‐CRP in individuals without dementia. Moreover, Aβ42 may encompass anti‐inflammatory effects reflected by reduced hs‐CRP levels.

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“…proinflammatory cytokines, and activated complement cascade proteins in plaques and neurofibrillary tangles (Duong et al, 1997;Iwamoto et al, 1994). In addition to β-amyloid,…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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The importance of the endocrine environment in the initiation of the ageing process has been elucidated in several in vivo an in vitro studies. Changes in endocrine pathways accompany healthy ageing, these include the growth hormone /insulin like growth factor-I axis (somatopause) and that of sexual hormones, namely estradiol (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulphate (adrenopause). The clinical significance of these changes is variable and results in morphological and functional alterations of all organ systems including the skin and the central nervous system. Moreover, the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones. Several studies have been conducted in an attempt to reverse the ageing process and clinical signs by substitution of the serum hormone levels in older individuals, however the benefits of hormone replacement therapy, if any, are still controversial. On the other hand, recent data suggest that skin is a window to the human organism and represents an adequate model for ageing research, also implying the use of skin samples for evaluating the ageing status of the central nervous system.

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Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections

Cited by 128 publications

References 17 publications

Alzheimer disease, inflammation, and novel inflammatory marker: resistin

Alzheimer disease, inflammation, and novel inflammatory marker: resistin

Decreased plasma C‐reactive protein levels in APOE ε4 allele carriers

Skin and brain age together: The role of hormones in the ageing process

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