Dendrimer Chemistry

Vögtle, Fritz; Richardt, Gabriele; Werner, Nicole E.

doi:10.1002/9783527626953

Cited by 322 publications

(167 citation statements)

References 0 publications

Supporting

Mentioning

162

Contrasting

Unclassified

Order By: Relevance

“…The first concerns the N dependence of g max and the onset of SIS effects. For long locally cylindrical DP, the current estimate of g max of this chemistry vary in the 6.1og max o7.1 range 50 and are thus consistent with onset of SIS 1,000 PGg and short 45 PGg series as obtained from the labelling absorbance data upon using equation (3). In the g range studied, the 45 PGg points are indistinguishable from the ideal values given by equation (4).…”

Section: Resultssupporting

confidence: 82%

“…The dendrons can be attached to point-like cores, to linear polymer chains or to surfaces thus giving rise to three leading structural families of dendritic molecules: dendrimers [1][2][3][4][5] , dendronized polymers (DP) [6][7][8][9] and forests [10][11][12] . Their masses and spans depend on their generation g specifying the number of branching sites along a path between the attachment site and the terminus.…”

mentioning

confidence: 99%

“…The crossover between the two regimes occurs at a theoretically well-defined g max 10,12-15 discussed below. Since the first reports of well-characterized dendrimers in 1985 (refs 16-19), thousands of research articles addressed their synthesis, properties and applications [1][2][3][4][5][6][7][8][9][20][21][22][23] . Recent activity in this area reflects a growing interest in biomedical applications such as bio-imaging, gene and drug delivery [24][25][26][27][28] .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Zhang

Schlüter

et al. 2013

Nat Commun

View full text Add to dashboard Cite

Classical theory predicts that branching defects are unavoidable in large dendritic molecules when steric congestion is important. Here we report first experimental evidence of this effect via labelling measurements of an extended homologous series of generations g ¼ 1y6 of dendronized polymers. This system exhibits a single type of defect interrogated specifically by the Sanger reagent thus permitting to identify the predicted upturn in the number of branching defects when g approaches g max and the polymer density approaches close packing. The average number of junctions and defects for each member of the series is recursively obtained from the measured molar concentrations of bound labels and the mass concentrations of the dendritic molecules. The number of defects increases at g ¼ 5 and becomes significant at g ¼ 6 for dendronized polymers where the g max was estimated to occur at 6.1 rg max r 7.1. The combination of labelling measurements with the novel theoretical analysis affords a method for characterizing high g dendritic systems.

show abstract

Section: Resultssupporting

confidence: 82%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Zhang

Schlüter

et al. 2013

Nat Commun

View full text Add to dashboard Cite

show abstract

“…Dendrimers are a class of polymeric compounds that can be distinguished from conventional linear polymers by their highly branched and symmetrical architecture [2]. Dendrimers are synthesized using a sequence of reactions, each time the sequence is conducted, the dendrimer is said to increase by one generation.…”

Section: Introductionmentioning

confidence: 99%

Structural studies of biologically active glycosylated polyamidoamine (PAMAM) dendrimers

et al. 2010

View full text Add to dashboard Cite

The partial modification of carboxylic acid terminated polyamidoamine (PAMAM) dendrimers with glucosamine has been reported to give dendrimer glucosamine conjugates novel immuno-modulatory and anti-angiogenic properties. Experimental analysis of these glycosylated dendrimers showed that, on average, eight glucosamine molecules were covalently bound to each dendrimer. In order to better understand the surface loading and distribution of these glucosamine molecules, molecular reactivity was determined by evaluation of electronic properties using frontier molecular orbital theory (FMOT) and molecular dynamics simulations. It was shown that the surface loading and distribution of the zero length amide bond conjugated glucosamine molecules was determined by both electronic effects and by the different dynamic conformations adopted by the modified dendrimer during the incremental addition of glucosamine. Importantly, the structural features and the dynamic behavior of the partially glycosylated generation 3.5 PAMAM dendrimer showed that its flexibility and its polarity changed with the incremental addition of glucosamine. These 2 peripheral glucosamine molecules remained available on the dendrimer"s surface for interaction with the biological target.

show abstract

“…Den-drimers have a unique dendritic architecture with regular cascade-branched repeating units emanating from a focal point and abundant terminal groups on the surface (Fig. 4) [43][44][45][46]. A large amount of contrast agent entities can be loaded either at the dendrimer terminals or in the interior, hence increasing the imaging enhancement.…”

Section: Mri Contrast Agents Based On Dendrimer Nanotechnologymentioning

confidence: 99%

Dendrimer-based magnetic resonance imaging agents for brain cancer

et al. 2018

View full text Add to dashboard Cite

Brain cancer is one of the most lethal and difficult-to-treat cancers because of its physical location and biological barriers. The mainstay of brain cancer treatment is surgical resection, which demands precise imaging for tumor localization and delineation. Thanks to advances in bioimaging, brain cancer can be detected earlier and resected more reliably. Magnetic resonance imaging (MRI) is the most common and preferred method to delineate brain cancer, and a contrast agent is often required to enhance imaging contrast. Dendrimers, a special family of synthetic macromolecules, constitute a particularly appealing platform for constructing MRI contrast agents by virtue of their well-defined three-dimensional structure, tunable nanosize and abundant surface terminals, which allow the accommodation of high payloads and numerous functionalities. Tuning the dendrimer size, branching and surface composition in conjunction with conjugation of MRI functionalities and targeting moieties can alter the relaxivity for MRI, overcome the blood-brain barrier and enhance tumor-specific targeting, hence improving the imaging quality and safety profile for precise and accurate imaging of brain tumors. This short review highlights the recent progress, opportunities and challenges in developing dendrimer-based MRI contrast agents for brain tumor imaging.

show abstract

Dendrimer Chemistry

Cited by 322 publications

References 0 publications

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Structural studies of biologically active glycosylated polyamidoamine (PAMAM) dendrimers

Dendrimer-based magnetic resonance imaging agents for brain cancer

Contact Info

Product

Resources

About