Dendrimer‐Related Nanoparticle System for Computed Tomography Imaging

Peng, Chen; Shi, Xiangyang

doi:10.1002/9781118275238.ch14

Cited by 4 publications

(1 citation statement)

References 85 publications

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“…In addition to the extensive studies of dendrimers in drug delivery, the development of dendrimer-mediated CNS imaging and diagnosis has attracted considerable attention. , PAMAM-PEG-T7 was explored to deliver MRI contrast agents to liver and early brain glioma tumors . PAMAM-PEG-T7 was conjugated with diethylene triamine pentaacetic acid (DTPA) and further chelated gadolinium (Gd) to yield Gd-DTPA-PAMAM-PEG-T7.…”

Section: Dendrimers For Cns Drug Delivery Imaging and Diagnosismentioning

confidence: 99%

Dendrimer Advances for the Central Nervous System Delivery of Therapeutics

Zhang

2013

ACS Chem. Neurosci.

146

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The effectiveness of noninvasive treatment for central nervous system (CNS) diseases is generally limited by the poor access of therapeutic agents into the CNS. Most CNS drugs cannot permeate into the brain parenchyma because of the blood-brain barrier (BBB), and overcoming this has become one of the most significant challenges in the development of CNS therapeutics. Rapid advances in nanotechnology have provided promising solutions to this challenge. This review discusses the latest applications of dendrimers in the treatment of CNS diseases with an emphasis on brain tumors. Dendrimer-mediated drug delivery, imaging, and diagnosis are also reviewed. The toxicity, biodistribution, and transport mechanisms in dendrimer-mediated delivery of CNS therapeutic agents bypassing or crossing the BBB are also discussed. Future directions and major challenges of dendrimer-mediated delivery of CNS therapeutic agents are included.

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Section: Dendrimers For Cns Drug Delivery Imaging and Diagnosismentioning

confidence: 99%

Dendrimer Advances for the Central Nervous System Delivery of Therapeutics

Zhang

2013

ACS Chem. Neurosci.

146

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Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine

Leiro

Santos

Lopes

et al. 2017

Adv Funct Materials

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Dendrimers have emerged as a powerful class of nanomaterials in the nanomedicine field due to their unique structural features: globular, welldefined, highly branched and controllable structure, nanosizescale, low polydispersity, and the presence of several terminal groups that can be functionalized with different ligands simulating the multivalency present in different biological systems. Although in its infancy, the application of dendrimers as therapeutics or theranostic tools in central nervous system (CNS) disorders is already significant and has opened promising avenues in the treatment of many conditions where the inherent "smartness" of the dendritic structures is being explored to effectively target the CNS. Here we present an overview of the past and future challenges of the use of dendrimers to respond to one of the ultimate challenges in the (nano)medicine field: to attain CNS repair and regeneration.

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