2019
DOI: 10.1002/chem.201805617
|View full text |Cite
|
Sign up to set email alerts
|

Dendrimeric Nanoparticles for Two‐Photon Photodynamic Therapy and Imaging: Synthesis, Photophysical Properties, Innocuousness in Daylight and Cytotoxicity under Two‐Photon Irradiation in the NIR

Abstract: The synthesis and the photophysical properties of a new class of fully organic monodisperse nanoparticles for combined two‐photon imaging and photodynamic therapy are described. The design of such nanoparticles is based on the covalent immobilization of a dedicated quadrupolar dye that combines excellent two‐photon absorbing (2PA) properties, fluorescence and singlet oxygen generation ability, in a phosphorous‐based dendrimeric architecture. First, a bifunctional quadrupolar dye bearing two different grafting … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
20
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
10

Relationship

4
6

Authors

Journals

citations
Cited by 34 publications
(20 citation statements)
references
References 87 publications
0
20
0
Order By: Relevance
“…On the contrary, under TPA conditions (irradiation at 760 nm for 3 × 1.57 s), this dendrimer is highly toxic for these cancerous cells. Thus, this dendrimer combines bioimaging properties with photodynamic therapy properties [ 108 ].…”
Section: Indirect Anticancer Activity Of Phosphorus Dendrimersmentioning
confidence: 99%
“…On the contrary, under TPA conditions (irradiation at 760 nm for 3 × 1.57 s), this dendrimer is highly toxic for these cancerous cells. Thus, this dendrimer combines bioimaging properties with photodynamic therapy properties [ 108 ].…”
Section: Indirect Anticancer Activity Of Phosphorus Dendrimersmentioning
confidence: 99%
“…Particularly noteworthy in this matter are compounds with two-photon absorption properties, potentially showing superior phototoxic activities (Bolze, Jenni, Sour, & Heitz, 2017). The idea of application of nanoparticles for two photon PDT is relatively new (Gao, Agayan, Xu, Philbert, & Kopelman, 2006;Sourdon et al, 2019), and has been reviewed elsewhere (Shen, Shuhendler, Ye, Xu, & Chen, 2016).…”
Section: Future Perspective: Nanoparticles For Two-photon Pdtmentioning
confidence: 99%
“…Several other dendrimers have been synthesized with the aim of possessing TPA properties, [59] and used for instance for in vivo imaging, [60] or for both imaging and photodynamic therapy. [61]…”
Section: Derivatives Of Fluorene As Constituents Of the Branches: Tramentioning
confidence: 99%