Dendrimers: Synthesis, Encapsulation Applications and Specific Interaction with the Stratum Corneum—A Review

Bacha, Katia; Chemotti, Catherine; Mbakidi, Jean‐Pierre; Deleu, Magali; Bouquillon, Sandrine

doi:10.3390/macromol3020022

Cited by 8 publications

(3 citation statements)

References 187 publications

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“…Dendrimers can be synthesized through a stepwise process known as divergent or convergent synthesis, beginning the preparation with a core molecule or starting with multiple branches, respectively. The choice of the technique depends on factors such as the desired dendrimer structure, functionality, and intended applications [ 151 ]. Additionally, various types of dendrimers, including polyamide amine (PAMAM) and polypropylene imine (PPI), can be synthesized using these methods, each with its own specific synthetic protocols.…”

Section: Current Nanotechnology-based Approaches For the Topical Trea...mentioning

confidence: 99%

Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles

Bodnár,

Fehér,

Ujhelyi

et al. 2024

Pharmaceutics

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Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of skin cells, which leads to the formation of thick, red, and scaly patches on the surface of the skin. These patches can be itchy and painful, and they may cause discomfort for patients affected by this condition. Therapies for psoriasis aim to alleviate symptoms, reduce inflammation, and slow down the excessive skin cell growth. Conventional topical treatment options are non-specific, have low efficacy and are associated with adverse effects, which is why researchers are investigating different delivery mechanisms. A novel approach to drug delivery using nanoparticles (NPs) shows promise in reducing toxicity and improving therapeutic efficacy. The unique properties of NPs, such as their small size and large surface area, make them attractive for targeted drug delivery, enhanced drug stability, and controlled release. In the context of PSO, NPs can be designed to deliver active ingredients with anti-inflammatory effect, immunosuppressants, or other therapeutic compounds directly to affected skin areas. These novel formulations offer improved access to the epidermis and facilitate better absorption, thus enhancing the therapeutic efficacy of conventional anti-psoriatic drugs. NPs increase the surface-to-volume ratio, resulting in enhanced penetration through the skin, including intracellular, intercellular, and trans-appendage routes. The present review aims to discuss the latest approaches for the topical therapy of PSO using NPs. It is intended to summarize the results of the in vitro and in vivo examinations carried out in the last few years regarding the effectiveness and safety of nanoparticles.

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Section: Current Nanotechnology-based Approaches For the Topical Trea...mentioning

confidence: 99%

Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles

Bodnár,

Fehér,

Ujhelyi

et al. 2024

Pharmaceutics

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“…Thus, due to their sorption ability dendrimers are used as single-molecule micelles for drug delivery applications. [4][5][6][7][8][9][10] Dendrimers are also widely used for the synthesis of hybrid organic-inorganic systems involving metal nanoparticles, carbon dots, etc., and the resulting hybrids can be used both for catalysis [11][12][13] and for the production of functional optical materials, including those with sensor 14 functions. 14,15 In the last decade, amphiphilic dendrimers, a broad series of dendrimers of asymmetric structure that includes core-shell dendrimers, Janus dendrimers, dendron-tail dendrimers as well as glycodendrimers, have attracted great attention.…”

Section: Introductionmentioning

confidence: 99%

Epichlorohydrin-based CuAAC dendrimers with a calix[4]arene core and polar hydroxyl/oxyethyl terminal groups: synthesis, aggregation and use in catalysis

Ocherednyuk,

Sultanova,

Makarov

et al. 2024

New J. Chem.

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“…Above this generation, the size of the PAMAM dendrimer cannot increase due to the lack of free space for branch growth. In general, small generations of dendrimers have an open, mobile, and asymmetric structure, and with increasing generation, this structure becomes more globular and densely packed (Bacha et al, 2023;Fréchet, 2003;Majoral et al, 2002;Merino et al, 2001;Ortega et al, 2006;Tomalia & Khanna, 2016;Vlasov, 2006).…”

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confidence: 99%

Recent advances in multifunctional dendrimer‐based complexes for cancer treatment

Shcharbin,

Zhogla,

Abashkin

et al. 2024

WIREs Nanomed Nanobiotechnol

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The application of nanotechnology in biological and medical fields have resulted in the creation of new devices, supramolecular systems, structures, complexes, and composites. Dendrimers are relatively new nanotechnological polymers with unique features; they are globular in shape, with a topological structure formed by monomeric subunit branches diverging to the sides from the central nucleus. This review analyzes the main features of dendrimers and their applications in biology and medicine regarding cancer treatment. Dendrimers have applications that include drug and gene carriers, antioxidant agents, imaging agents, and adjuvants, but importantly, dendrimers can create complex nanosized constructions that combine features such as drug/gene carriers and imaging agents. Dendrimer‐based nanosystems include different metals that enhance oxidative stress, polyethylene glycol to provide biosafety, an imaging agent (a fluorescent, radioactive, magnetic resonance imaging probe), a drug or/and nucleic acid that provides a single or dual action on cells or tissues. One of major benefit of dendrimers is their easy release from the body (in contrast to metal nanoparticles, fullerenes, and carbon nanotubes), allowing the creation of biosafe constructions. Some dendrimers are already clinically approved and are being used as drugs, but many nanocomplexes are currently being studied for clinical practice. In summary, dendrimers are very useful tool in the creation of complex nanoconstructions for personalized nanomedicine.This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Dendrimers: Synthesis, Encapsulation Applications and Specific Interaction with the Stratum Corneum—A Review

Cited by 8 publications

References 187 publications

Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles

Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles

Epichlorohydrin-based CuAAC dendrimers with a calix[4]arene core and polar hydroxyl/oxyethyl terminal groups: synthesis, aggregation and use in catalysis

Recent advances in multifunctional dendrimer‐based complexes for cancer treatment

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