Dendritic Architectures with Positively Charged Cores and Negatively Charged Shells

This review presents precisely defined amphiphilic dendrons, their self‐association properties, and their different uses. Dendrons, also named dendritic wedges, are composed of a core having two different types of functions, of which one type is used for growing or grafting branched arms, generally multiplied by 2 at each layer by using 1→2 branching motifs. A large diversity of structures has been already synthesized. In practically all cases, their synthesis is based on the synthesis of known dendrimers, such as poly(aryl ether), poly(amidoamine) (in particular PAMAM), poly(amide) (in particular poly(L‐lysine)), 1→3 branching motifs (instead of 1→2), poly(alkyl ether) (poly(glycerol) and poly(ethylene glycol)), poly(ester), and those containing main group elements (poly(carbosilane) and poly(phosphorhydrazone)). In most cases, the hydrophilic functions are on the surface of the dendrons, whereas one or two hydrophobic tails are linked to the core. Depending on the structure of the dendrons, and on the experimental conditions used, the amphiphilic dendrons can self‐associate at the air‐water interface, or form micelles (eventually tubular, but most generally spherical), or form vesicles. These associated dendrons are suitable for the encapsulation of low‐molecular or macromolecular bioactive entities to be delivered in cells. This review is organized depending on the nature of the internal structure of the amphiphilic dendrons (aryl ether, amidoamine, amide, quaternary carbon atom, alkyl ether, ester, main group element). The properties issued from their self‐associations are described all along the review.

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“…Several dendrons were synthesized; the one shown in Figure 28 had the most pronounced tendency to form spherical micelles. [94] …”

Section: Amphiphilic Dendrons Based On Quaternary Carbon Atoms As Bra...mentioning

confidence: 99%

“…Another example concerned cationic pyridinium branching units, surrounded by negatively charged carboxylic acids, and bearing a long alkyl chain at the core. Several dendrons were synthesized; the one shown in Figure 28 had the most pronounced tendency to form spherical micelles [94] …”

Section: Amphiphilic Dendrons Based On Quaternary Carbon Atoms As Bra...mentioning

confidence: 99%

Supramolecular Self‐Associations of Amphiphilic Dendrons and Their Properties

Apartsin

Caminade

2021

Chemistry A European J

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“…The oppositely charged core and shell in the second example might be somewhat unexpected. However, it is possible to make dendrimers with this type of architecture [ 26 ].…”

Section: Application To Core–shell Microgelsmentioning

confidence: 99%

Effective Interactions between Multilayered Ionic Microgels

2014

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Using a one-component reduction formalism, we calculate the effective interactions and the counterion density profiles for microgels that feature a multilayered shell structure. We follow a strategy that involves second order perturbation theory and obtain analytical expressions for the effective interactions by modeling the layers of the particles as linear superpostion of homogeneously charged spheres. The general method is applied to the important case of core–shell microgels and compared with the well-known results for a microgel that can be approximated by a macroscopic, and homogeneously charged, spherical macroion.

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“…In recent years, we have developed various dendrimers containing biobased moieties to make these compounds more eco-compatible. These have been used in catalysis, medical imaging and depollution [5][6][7][8]. The present study is devoted to the preparation of new ionic dendrimers that present, moreover, antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

“…However, the synthesis of ionic dendrimers has previously been described in the literature, for example, dendronized pyridinium units surrounded by a shell of carboxylic acids [8] or water-soluble polyanionic dendrimers, presenting great potential applications as antiviral drugs [9]. Ionic dendrimers have also been used as a base for polyamide membranes for ion separation [10] or electrolytes for LiS batteries [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Activity of Ionic Antioxidant-Functionalized PAMAMs and PPIs Dendrimers

et al. 2022

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For this study, new dendrimers were prepared from poly(propylene imine) (PPI) and polyamidoamine (PAMAM) dendrimers using an efficient acid-base reaction with various phenolic acids. The syntheses were also optimized in both microwave and microfluidic reactors. These ionic and hydrophilic dendrimers were fully characterized and showed excellent antioxidant properties. Their cytotoxic properties have been also determined in the case of fibroblast dermal cells.

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Dendritic Architectures with Positively Charged Cores and Negatively Charged Shells

Cited by 4 publications

References 33 publications

Supramolecular Self‐Associations of Amphiphilic Dendrons and Their Properties

Supramolecular Self‐Associations of Amphiphilic Dendrons and Their Properties

Effective Interactions between Multilayered Ionic Microgels

Synthesis and Activity of Ionic Antioxidant-Functionalized PAMAMs and PPIs Dendrimers

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